N-(3-fluoro-4-(2-arylthieno[3,2- b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: A novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors

A series of N-(3-fluoro-4-(2-arylthieno[3,2- b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides ( II) targeting c-Met and VEGFR2 tyrosine kinases, based on our previous acetylthiourea series ( I), was designed and synthesized. The new compounds were potent against these two enzymes...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-03, Vol.19 (5), p.1323-1328
Hauptverfasser:	Raeppel, Stéphane, Claridge, Stephen, Saavedra, Oscar, Gaudette, Frédéric, Zhan, Lijie, Mannion, Michael, Zhou, Nancy, Raeppel, Franck, Granger, Marie-Claude, Isakovic, Ljubomir, Déziel, Robert, Nguyen, Hannah, Beaulieu, Normand, Beaulieu, Carole, Dupont, Isabelle, Robert, Marie-France, Lefebvre, Sylvain, Dubay, Marja, Rahil, Jubrail, Wang, James, Ste-Croix, Hélène, Robert Macleod, A., Besterman, Jeffrey, Vaisburg, Arkadii
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Amides - pharmacology Animals c-Met Cell Line, Tumor HCT116 Cells Humans Imidazolidines - chemistry Imidazolidines - pharmacology Mice Oncology Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-met - administration & dosage Rats Receptor Protein-Tyrosine Kinases - antagonists & inhibitors RTK inhibitors Thieno[3,2- b]pyridine scaffold Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - metabolism VEGFR2 Xenograft Model Antitumor Assays - methods
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