Degradation of mesh coatings and intraperitoneal adhesion formation in an experimental model
Background: In laparoscopic ventral hernia repair a mesh is placed in direct contact with the viscera, often leading to substantial adhesions. In this experimental study the ability of different coated and uncoated meshes to attenuate adhesion formation was examined. Methods: Six commercially availa...
Gespeichert in:
| Veröffentlicht in: | British journal of surgery 2009-03, Vol.96 (3), p.305-313 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 313 |
|---|---|
| container_issue | 3 |
| container_start_page | 305 |
| container_title | British journal of surgery |
| container_volume | 96 |
| creator | Schreinemacher, M. H. F. Emans, P. J. Gijbels, M. J. J. Greve, J.-W. M. Beets, G. L. Bouvy, N. D. |
| description | Background:
In laparoscopic ventral hernia repair a mesh is placed in direct contact with the viscera, often leading to substantial adhesions. In this experimental study the ability of different coated and uncoated meshes to attenuate adhesion formation was examined.
Methods:
Six commercially available meshes were placed intraperitoneally against a closed peritoneum in rats: Prolene® (polypropylene), Timesh® and Ultrapro® (polypropylene composites with titanium and polyglecaprone respectively), Proceed® and Parietex Composite® (polypropylene and polyester meshes coated with a layer of cellulose and collagen respectively) and C‐Qur® (polypropylene mesh coated with a layer of omega‐3 fatty acids). Adhesions and incorporation were evaluated macroscopically and microscopically after 7 and 30 days.
Results:
Parietex Composite® and C‐Qur® significantly reduced adhesion formation at 7 days' follow‐up compared with all other meshes. By 30 days, this effect had diminished as a significant increase in adhesions together with phagocytosis of the coating was seen for all meshes with layered coatings (Proceed®, Parietex Composite® and C‐Qur®). Incorporation was insufficient for all meshes.
Conclusion:
The absorbable layers of Parietex Composite® and C‐Qur® reduce adhesion formation to intraperitoneal mesh in the short term, but the effect diminishes and phagocytosis of absorbable coatings may contribute to adhesion formation. Copyright © 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Coatings have short‐term effect only |
| doi_str_mv | 10.1002/bjs.6446 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_66951171</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66951171</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3886-95e791aa29c8ed017bf80c0c0ff8dece208bd5eed3c84f23f13528fe358a8553</originalsourceid><addsrcrecordid>eNpF0W1LHDEQB_BQKvV6FvwEsm_ad6uZZJPNvvShni0-QY8KIoRcMtHV3ex1s4f67ZvlTmVeDAO_DEP-hOwC3QdK2cHiMe7LopCfyAS4FDkDqT6TCaW0zIEzvk2-xvhIKXAq2BeyDRVjhWAwIXcneN8bZ4a6C1nnsxbjQ2a7NIf7mJngsjoMvVliXw9dQNNkxj1gHLXv-nb9rg5JZvgyqhbDkFTbOWx2yJY3TcRvmz4l89Of8-Oz_Pxq9uv48Dy3XCmZVwLLCoxhlVXoKJQLr6hN5b1yaJFRtXAC0XGrCs-4By6Y8siFMkoIPiU_1muXffdvhXHQbR0tNo0J2K2ilrISACUkuLeBq0WLTi_TuaZ_1W_fkcD3DTDRmsb3Jtg6vjsGUEC6Jrl87Z7rBl8_9lA9xqFTHHqMQx_9_jP2D1_HAV_evemftCx5KfTN5UzL6_npxV9xq4H_B6RxjGQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>66951171</pqid></control><display><type>article</type><title>Degradation of mesh coatings and intraperitoneal adhesion formation in an experimental model</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Schreinemacher, M. H. F. ; Emans, P. J. ; Gijbels, M. J. J. ; Greve, J.-W. M. ; Beets, G. L. ; Bouvy, N. D.</creator><creatorcontrib>Schreinemacher, M. H. F. ; Emans, P. J. ; Gijbels, M. J. J. ; Greve, J.-W. M. ; Beets, G. L. ; Bouvy, N. D.</creatorcontrib><description>Background:
In laparoscopic ventral hernia repair a mesh is placed in direct contact with the viscera, often leading to substantial adhesions. In this experimental study the ability of different coated and uncoated meshes to attenuate adhesion formation was examined.
Methods:
Six commercially available meshes were placed intraperitoneally against a closed peritoneum in rats: Prolene® (polypropylene), Timesh® and Ultrapro® (polypropylene composites with titanium and polyglecaprone respectively), Proceed® and Parietex Composite® (polypropylene and polyester meshes coated with a layer of cellulose and collagen respectively) and C‐Qur® (polypropylene mesh coated with a layer of omega‐3 fatty acids). Adhesions and incorporation were evaluated macroscopically and microscopically after 7 and 30 days.
Results:
Parietex Composite® and C‐Qur® significantly reduced adhesion formation at 7 days' follow‐up compared with all other meshes. By 30 days, this effect had diminished as a significant increase in adhesions together with phagocytosis of the coating was seen for all meshes with layered coatings (Proceed®, Parietex Composite® and C‐Qur®). Incorporation was insufficient for all meshes.
Conclusion:
The absorbable layers of Parietex Composite® and C‐Qur® reduce adhesion formation to intraperitoneal mesh in the short term, but the effect diminishes and phagocytosis of absorbable coatings may contribute to adhesion formation. Copyright © 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Coatings have short‐term effect only</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.6446</identifier><identifier>PMID: 19224521</identifier><identifier>CODEN: BJSUAM</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; Biological and medical sciences ; General aspects ; Granulation Tissue - pathology ; Medical sciences ; Peritoneum - surgery ; Rats ; Rats, Wistar ; Surgical Mesh ; Tissue Adhesions - etiology ; Tissue Adhesions - pathology</subject><ispartof>British journal of surgery, 2009-03, Vol.96 (3), p.305-313</ispartof><rights>Copyright © 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3886-95e791aa29c8ed017bf80c0c0ff8dece208bd5eed3c84f23f13528fe358a8553</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.6446$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.6446$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21141208$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19224521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schreinemacher, M. H. F.</creatorcontrib><creatorcontrib>Emans, P. J.</creatorcontrib><creatorcontrib>Gijbels, M. J. J.</creatorcontrib><creatorcontrib>Greve, J.-W. M.</creatorcontrib><creatorcontrib>Beets, G. L.</creatorcontrib><creatorcontrib>Bouvy, N. D.</creatorcontrib><title>Degradation of mesh coatings and intraperitoneal adhesion formation in an experimental model</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>Background:
In laparoscopic ventral hernia repair a mesh is placed in direct contact with the viscera, often leading to substantial adhesions. In this experimental study the ability of different coated and uncoated meshes to attenuate adhesion formation was examined.
Methods:
Six commercially available meshes were placed intraperitoneally against a closed peritoneum in rats: Prolene® (polypropylene), Timesh® and Ultrapro® (polypropylene composites with titanium and polyglecaprone respectively), Proceed® and Parietex Composite® (polypropylene and polyester meshes coated with a layer of cellulose and collagen respectively) and C‐Qur® (polypropylene mesh coated with a layer of omega‐3 fatty acids). Adhesions and incorporation were evaluated macroscopically and microscopically after 7 and 30 days.
Results:
Parietex Composite® and C‐Qur® significantly reduced adhesion formation at 7 days' follow‐up compared with all other meshes. By 30 days, this effect had diminished as a significant increase in adhesions together with phagocytosis of the coating was seen for all meshes with layered coatings (Proceed®, Parietex Composite® and C‐Qur®). Incorporation was insufficient for all meshes.
Conclusion:
The absorbable layers of Parietex Composite® and C‐Qur® reduce adhesion formation to intraperitoneal mesh in the short term, but the effect diminishes and phagocytosis of absorbable coatings may contribute to adhesion formation. Copyright © 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Coatings have short‐term effect only</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>General aspects</subject><subject>Granulation Tissue - pathology</subject><subject>Medical sciences</subject><subject>Peritoneum - surgery</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Surgical Mesh</subject><subject>Tissue Adhesions - etiology</subject><subject>Tissue Adhesions - pathology</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0W1LHDEQB_BQKvV6FvwEsm_ad6uZZJPNvvShni0-QY8KIoRcMtHV3ex1s4f67ZvlTmVeDAO_DEP-hOwC3QdK2cHiMe7LopCfyAS4FDkDqT6TCaW0zIEzvk2-xvhIKXAq2BeyDRVjhWAwIXcneN8bZ4a6C1nnsxbjQ2a7NIf7mJngsjoMvVliXw9dQNNkxj1gHLXv-nb9rg5JZvgyqhbDkFTbOWx2yJY3TcRvmz4l89Of8-Oz_Pxq9uv48Dy3XCmZVwLLCoxhlVXoKJQLr6hN5b1yaJFRtXAC0XGrCs-4By6Y8siFMkoIPiU_1muXffdvhXHQbR0tNo0J2K2ilrISACUkuLeBq0WLTi_TuaZ_1W_fkcD3DTDRmsb3Jtg6vjsGUEC6Jrl87Z7rBl8_9lA9xqFTHHqMQx_9_jP2D1_HAV_evemftCx5KfTN5UzL6_npxV9xq4H_B6RxjGQ</recordid><startdate>200903</startdate><enddate>200903</enddate><creator>Schreinemacher, M. H. F.</creator><creator>Emans, P. J.</creator><creator>Gijbels, M. J. J.</creator><creator>Greve, J.-W. M.</creator><creator>Beets, G. L.</creator><creator>Bouvy, N. D.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200903</creationdate><title>Degradation of mesh coatings and intraperitoneal adhesion formation in an experimental model</title><author>Schreinemacher, M. H. F. ; Emans, P. J. ; Gijbels, M. J. J. ; Greve, J.-W. M. ; Beets, G. L. ; Bouvy, N. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3886-95e791aa29c8ed017bf80c0c0ff8dece208bd5eed3c84f23f13528fe358a8553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>General aspects</topic><topic>Granulation Tissue - pathology</topic><topic>Medical sciences</topic><topic>Peritoneum - surgery</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Surgical Mesh</topic><topic>Tissue Adhesions - etiology</topic><topic>Tissue Adhesions - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schreinemacher, M. H. F.</creatorcontrib><creatorcontrib>Emans, P. J.</creatorcontrib><creatorcontrib>Gijbels, M. J. J.</creatorcontrib><creatorcontrib>Greve, J.-W. M.</creatorcontrib><creatorcontrib>Beets, G. L.</creatorcontrib><creatorcontrib>Bouvy, N. D.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schreinemacher, M. H. F.</au><au>Emans, P. J.</au><au>Gijbels, M. J. J.</au><au>Greve, J.-W. M.</au><au>Beets, G. L.</au><au>Bouvy, N. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Degradation of mesh coatings and intraperitoneal adhesion formation in an experimental model</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>2009-03</date><risdate>2009</risdate><volume>96</volume><issue>3</issue><spage>305</spage><epage>313</epage><pages>305-313</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><abstract>Background:
In laparoscopic ventral hernia repair a mesh is placed in direct contact with the viscera, often leading to substantial adhesions. In this experimental study the ability of different coated and uncoated meshes to attenuate adhesion formation was examined.
Methods:
Six commercially available meshes were placed intraperitoneally against a closed peritoneum in rats: Prolene® (polypropylene), Timesh® and Ultrapro® (polypropylene composites with titanium and polyglecaprone respectively), Proceed® and Parietex Composite® (polypropylene and polyester meshes coated with a layer of cellulose and collagen respectively) and C‐Qur® (polypropylene mesh coated with a layer of omega‐3 fatty acids). Adhesions and incorporation were evaluated macroscopically and microscopically after 7 and 30 days.
Results:
Parietex Composite® and C‐Qur® significantly reduced adhesion formation at 7 days' follow‐up compared with all other meshes. By 30 days, this effect had diminished as a significant increase in adhesions together with phagocytosis of the coating was seen for all meshes with layered coatings (Proceed®, Parietex Composite® and C‐Qur®). Incorporation was insufficient for all meshes.
Conclusion:
The absorbable layers of Parietex Composite® and C‐Qur® reduce adhesion formation to intraperitoneal mesh in the short term, but the effect diminishes and phagocytosis of absorbable coatings may contribute to adhesion formation. Copyright © 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Coatings have short‐term effect only</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>19224521</pmid><doi>10.1002/bjs.6446</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1323 |
| ispartof | British journal of surgery, 2009-03, Vol.96 (3), p.305-313 |
| issn | 0007-1323 1365-2168 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66951171 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Animals Biological and medical sciences General aspects Granulation Tissue - pathology Medical sciences Peritoneum - surgery Rats Rats, Wistar Surgical Mesh Tissue Adhesions - etiology Tissue Adhesions - pathology |
| title | Degradation of mesh coatings and intraperitoneal adhesion formation in an experimental model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T09%3A33%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Degradation%20of%20mesh%20coatings%20and%20intraperitoneal%20adhesion%20formation%20in%20an%20experimental%20model&rft.jtitle=British%20journal%20of%20surgery&rft.au=Schreinemacher,%20M.%20H.%20F.&rft.date=2009-03&rft.volume=96&rft.issue=3&rft.spage=305&rft.epage=313&rft.pages=305-313&rft.issn=0007-1323&rft.eissn=1365-2168&rft.coden=BJSUAM&rft_id=info:doi/10.1002/bjs.6446&rft_dat=%3Cproquest_pubme%3E66951171%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=66951171&rft_id=info:pmid/19224521&rfr_iscdi=true |