Remarkable enhancement in the DNA-binding ability of C2-fluoro substituted pyrrolo[2,1- c][1,4]benzodiazepines and their anticancer potential

C2-Fluoro substituted DC-81, and its dimers that comprise of two C2-fluoro substituted DC-81 subunits tethered to their C8-position through simple alkane spacers as well as piperazine moiety side-armed with symmetrical alkyloxy spacers have been designed and synthesized. These fluoro substituted pyr...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2009-02, Vol.17 (4), p.1557-1572
Hauptverfasser:	Kamal, Ahmed, Rajender, Reddy, D. Rajasekhar, Reddy, M. Kashi, Balakishan, G., Shaik, T. Basha, Chourasia, Mukesh, Sastry, G. Narahari
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer activity Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Benzodiazepines - metabolism Benzodiazepines - pharmacology Cell Line, Tumor DNA - drug effects DNA - metabolism DNA Restriction Enzymes - metabolism DNA-binding affinity Drug Design Drug Screening Assays, Antitumor Fluoro Humans Models, Molecular Piperazine Pyrrolidines - metabolism Pyrrolidines - pharmacology Pyrrolobenzodiazepine Structure-Activity Relationship
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