Effect of weight loss through laparoscopic gastric banding on blood pressure, plasma renin activity and aldosterone levels in morbid obesity
Abstract Background and aims Several mechanisms are probably involved in obesity-related hypertension. This study was aimed to investigate the effect of significant weight loss on blood pressure and plasma renin activity (PRA) and aldosterone levels, other then on metabolic profile, in normotensive...
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| Veröffentlicht in: | Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2009-02, Vol.19 (2), p.110-114 |
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| creator | Dall'Asta, C Vedani, P Manunta, P Pizzocri, P Marchi, M Paganelli, M Folli, F Pontiroli, A.E |
| description | Abstract Background and aims Several mechanisms are probably involved in obesity-related hypertension. This study was aimed to investigate the effect of significant weight loss on blood pressure and plasma renin activity (PRA) and aldosterone levels, other then on metabolic profile, in normotensive and hypertensive obese subjects. Methods and results Forty hypertensive and 55 normotensive obese subjects were studied under basal conditions and again 1 year after significant weight loss obtained through laparoscopic adjustable gastric banding (LAGB). Weight, waist circumference, blood glucose, insulin, electrolytes (Na and K), lipids and supine and upright PRA and aldosterone were evaluated. All parameters evaluated improved, except for total cholesterol, and electrolytes that did not change. Blood pressure decreased in hypertensive subjects, with a concordant decrease in PRA and supine aldosterone levels, not observed in normotensive patients. Conclusion Weight loss is associated with reduction of blood pressure and of PRA and aldosterone levels in obese hypertensive subjects. |
| doi_str_mv | 10.1016/j.numecd.2008.06.001 |
| format | Article |
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This study was aimed to investigate the effect of significant weight loss on blood pressure and plasma renin activity (PRA) and aldosterone levels, other then on metabolic profile, in normotensive and hypertensive obese subjects. Methods and results Forty hypertensive and 55 normotensive obese subjects were studied under basal conditions and again 1 year after significant weight loss obtained through laparoscopic adjustable gastric banding (LAGB). Weight, waist circumference, blood glucose, insulin, electrolytes (Na and K), lipids and supine and upright PRA and aldosterone were evaluated. All parameters evaluated improved, except for total cholesterol, and electrolytes that did not change. Blood pressure decreased in hypertensive subjects, with a concordant decrease in PRA and supine aldosterone levels, not observed in normotensive patients. Conclusion Weight loss is associated with reduction of blood pressure and of PRA and aldosterone levels in obese hypertensive subjects.</description><identifier>ISSN: 0939-4753</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2008.06.001</identifier><identifier>PMID: 18718746</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aldosterone ; Aldosterone - blood ; Arterial hypertension ; Bariatric surgery ; Bariatric Surgery - methods ; Blood Glucose - metabolism ; Blood Pressure ; Cardiovascular ; Down-Regulation ; Female ; Humans ; Hypertension - blood ; Hypertension - etiology ; Hypertension - physiopathology ; Insulin - blood ; Laparoscopy ; Lipids - blood ; Male ; Middle Aged ; Obesity ; Obesity, Morbid - blood ; Obesity, Morbid - complications ; Obesity, Morbid - physiopathology ; Obesity, Morbid - surgery ; Potassium - blood ; Renin ; Renin - blood ; Renin-Angiotensin System ; Sodium - blood ; Time Factors ; Treatment Outcome ; Waist Circumference ; Weight Loss</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2009-02, Vol.19 (2), p.110-114</ispartof><rights>Elsevier B.V.</rights><rights>2008 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-9800c10530d5526888628cee6c57dc2f401c13be890d79dfea3ac09433ebbe6b3</citedby><cites>FETCH-LOGICAL-c481t-9800c10530d5526888628cee6c57dc2f401c13be890d79dfea3ac09433ebbe6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0939475308001142$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18718746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dall'Asta, C</creatorcontrib><creatorcontrib>Vedani, P</creatorcontrib><creatorcontrib>Manunta, P</creatorcontrib><creatorcontrib>Pizzocri, P</creatorcontrib><creatorcontrib>Marchi, M</creatorcontrib><creatorcontrib>Paganelli, M</creatorcontrib><creatorcontrib>Folli, F</creatorcontrib><creatorcontrib>Pontiroli, A.E</creatorcontrib><title>Effect of weight loss through laparoscopic gastric banding on blood pressure, plasma renin activity and aldosterone levels in morbid obesity</title><title>Nutrition, metabolism, and cardiovascular diseases</title><addtitle>Nutr Metab Cardiovasc Dis</addtitle><description>Abstract Background and aims Several mechanisms are probably involved in obesity-related hypertension. This study was aimed to investigate the effect of significant weight loss on blood pressure and plasma renin activity (PRA) and aldosterone levels, other then on metabolic profile, in normotensive and hypertensive obese subjects. Methods and results Forty hypertensive and 55 normotensive obese subjects were studied under basal conditions and again 1 year after significant weight loss obtained through laparoscopic adjustable gastric banding (LAGB). Weight, waist circumference, blood glucose, insulin, electrolytes (Na and K), lipids and supine and upright PRA and aldosterone were evaluated. All parameters evaluated improved, except for total cholesterol, and electrolytes that did not change. Blood pressure decreased in hypertensive subjects, with a concordant decrease in PRA and supine aldosterone levels, not observed in normotensive patients. Conclusion Weight loss is associated with reduction of blood pressure and of PRA and aldosterone levels in obese hypertensive subjects.</description><subject>Adult</subject><subject>Aldosterone</subject><subject>Aldosterone - blood</subject><subject>Arterial hypertension</subject><subject>Bariatric surgery</subject><subject>Bariatric Surgery - methods</subject><subject>Blood Glucose - metabolism</subject><subject>Blood Pressure</subject><subject>Cardiovascular</subject><subject>Down-Regulation</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Hypertension - etiology</subject><subject>Hypertension - physiopathology</subject><subject>Insulin - blood</subject><subject>Laparoscopy</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity, Morbid - blood</subject><subject>Obesity, Morbid - complications</subject><subject>Obesity, Morbid - physiopathology</subject><subject>Obesity, Morbid - surgery</subject><subject>Potassium - blood</subject><subject>Renin</subject><subject>Renin - blood</subject><subject>Renin-Angiotensin System</subject><subject>Sodium - blood</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Waist Circumference</subject><subject>Weight Loss</subject><issn>0939-4753</issn><issn>1590-3729</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2r1DAUhoso3vHqPxDJypUdT5o2bTeCXK4fcMGFug5pcjqTMU1qTjsy_8EfbYYZENwIgbN5zht43lMULzlsOXD59rAN64TGbiuAbgtyC8AfFRve9FCKtuofFxvoRV_WbSNuimdEBwDRgqifFje8a_Or5ab4fT-OaBYWR_YL3W6_MB-J2LJPcd3tmdezTpFMnJ1hO01LynPQwbqwYzGwwcdo2ZyQaE34hs1e06RZwuAC02ZxR7ecWOaZ9jbSgikGZB6P6IllZIppcJbFASmDz4sno_aEL67ztvj-4f7b3afy4cvHz3fvH0pTd3wp-w7AcGgE2KapZNd1suoMojRNa0011sANFwN2Pdi2tyNqoQ30tRA4DCgHcVu8vuTOKf5ckRY1OTLovQ4YV1JS9k0W1WawvoAmS6CEo5qTm3Q6KQ7q3II6qEsL6tyCAqlyC3nt1TV_HSa0f5eu2jPw7gJkDXh0mBQZh8GgdSm3oWx0__vh3wDjXXBG-x94QjrENYVsUHFFlQL19XwJ50OArI7zuhJ_AJ_Jsp0</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Dall'Asta, C</creator><creator>Vedani, P</creator><creator>Manunta, P</creator><creator>Pizzocri, P</creator><creator>Marchi, M</creator><creator>Paganelli, M</creator><creator>Folli, F</creator><creator>Pontiroli, A.E</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090201</creationdate><title>Effect of weight loss through laparoscopic gastric banding on blood pressure, plasma renin activity and aldosterone levels in morbid obesity</title><author>Dall'Asta, C ; Vedani, P ; Manunta, P ; Pizzocri, P ; Marchi, M ; Paganelli, M ; Folli, F ; Pontiroli, A.E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-9800c10530d5526888628cee6c57dc2f401c13be890d79dfea3ac09433ebbe6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aldosterone</topic><topic>Aldosterone - blood</topic><topic>Arterial hypertension</topic><topic>Bariatric surgery</topic><topic>Bariatric Surgery - methods</topic><topic>Blood Glucose - metabolism</topic><topic>Blood Pressure</topic><topic>Cardiovascular</topic><topic>Down-Regulation</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - blood</topic><topic>Hypertension - etiology</topic><topic>Hypertension - physiopathology</topic><topic>Insulin - blood</topic><topic>Laparoscopy</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity, Morbid - blood</topic><topic>Obesity, Morbid - complications</topic><topic>Obesity, Morbid - physiopathology</topic><topic>Obesity, Morbid - surgery</topic><topic>Potassium - blood</topic><topic>Renin</topic><topic>Renin - blood</topic><topic>Renin-Angiotensin System</topic><topic>Sodium - blood</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Waist Circumference</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dall'Asta, C</creatorcontrib><creatorcontrib>Vedani, P</creatorcontrib><creatorcontrib>Manunta, P</creatorcontrib><creatorcontrib>Pizzocri, P</creatorcontrib><creatorcontrib>Marchi, M</creatorcontrib><creatorcontrib>Paganelli, M</creatorcontrib><creatorcontrib>Folli, F</creatorcontrib><creatorcontrib>Pontiroli, A.E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dall'Asta, C</au><au>Vedani, P</au><au>Manunta, P</au><au>Pizzocri, P</au><au>Marchi, M</au><au>Paganelli, M</au><au>Folli, F</au><au>Pontiroli, A.E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of weight loss through laparoscopic gastric banding on blood pressure, plasma renin activity and aldosterone levels in morbid obesity</atitle><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle><addtitle>Nutr Metab Cardiovasc Dis</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>19</volume><issue>2</issue><spage>110</spage><epage>114</epage><pages>110-114</pages><issn>0939-4753</issn><eissn>1590-3729</eissn><abstract>Abstract Background and aims Several mechanisms are probably involved in obesity-related hypertension. This study was aimed to investigate the effect of significant weight loss on blood pressure and plasma renin activity (PRA) and aldosterone levels, other then on metabolic profile, in normotensive and hypertensive obese subjects. Methods and results Forty hypertensive and 55 normotensive obese subjects were studied under basal conditions and again 1 year after significant weight loss obtained through laparoscopic adjustable gastric banding (LAGB). Weight, waist circumference, blood glucose, insulin, electrolytes (Na and K), lipids and supine and upright PRA and aldosterone were evaluated. All parameters evaluated improved, except for total cholesterol, and electrolytes that did not change. Blood pressure decreased in hypertensive subjects, with a concordant decrease in PRA and supine aldosterone levels, not observed in normotensive patients. 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| subjects | Adult Aldosterone Aldosterone - blood Arterial hypertension Bariatric surgery Bariatric Surgery - methods Blood Glucose - metabolism Blood Pressure Cardiovascular Down-Regulation Female Humans Hypertension - blood Hypertension - etiology Hypertension - physiopathology Insulin - blood Laparoscopy Lipids - blood Male Middle Aged Obesity Obesity, Morbid - blood Obesity, Morbid - complications Obesity, Morbid - physiopathology Obesity, Morbid - surgery Potassium - blood Renin Renin - blood Renin-Angiotensin System Sodium - blood Time Factors Treatment Outcome Waist Circumference Weight Loss |
| title | Effect of weight loss through laparoscopic gastric banding on blood pressure, plasma renin activity and aldosterone levels in morbid obesity |
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