Immunological responses to pneumococcal vaccine in frail older people

Abstract Advanced age has been associated with a wide range of defects in both the innate and adaptive immune systems including diminished specific antibody responses that increase the risk of invasive pneumococcal disease (IPD) and limit the effectiveness of vaccines. However, the elderly are a het...

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Veröffentlicht in:	Vaccine 2009-03, Vol.27 (10), p.1628-1636
Hauptverfasser:	Ridda, I, MacIntyre, C.R, Lindley, R, Gao, Z, Sullivan, J.S, Yuan, F.F, McIntyre, P.B
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Allergy and Immunology Antibodies, Bacterial - blood Applied microbiology Bacterial diseases Bacteriology Biological and medical sciences Female Frail Frail Elderly Frailty Fundamental and applied biological sciences. Psychology Heptavalent Pneumococcal Conjugate Vaccine Human bacterial diseases Humans Immune response Immune responses Immunization Immunogenicity Immunoglobulin G - blood Infectious diseases Male Medical sciences Microbiology Middle Aged Miscellaneous Older people Pneumococcal disease Pneumococcal Infections - immunology Pneumococcal Infections - prevention & control Pneumococcal vaccines Pneumococcal Vaccines - immunology Pneumococcal Vaccines - pharmacology Pneumonia Staphylococcal infections, streptococcal infections, pneumococcal infections Streptococcus pneumoniae Streptococcus pneumoniae - classification Streptococcus pneumoniae - immunology Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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