R-Spondin2 Is a Secreted Activator of Wnt/β-Catenin Signaling and Is Required for Xenopus Myogenesis

We have carried out a small pool expression screen for modulators of the Wnt/β-catenin pathway and identified Xenopus R-spondin2 ( Rspo2) as a secreted activator of this cascade. Rspo2 is coexpressed with and positively regulated by Wnt signals and synergizes with Wnts to activate β-catenin. Analyse...

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Veröffentlicht in:	Developmental cell 2004-10, Vol.7 (4), p.525-534
Hauptverfasser:	Kazanskaya, Olga, Glinka, Andrei, del Barco Barrantes, Ivan, Stannek, Peter, Niehrs, Christof, Wu, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin Blotting, Western Cell Line Culture Techniques - methods Cytoskeletal Proteins Extracellular Matrix Proteins Genes, Reporter HeLa Cells Humans Immunohistochemistry In Situ Hybridization Luciferases - metabolism Microinjections Molecular Sequence Data Muscle Development Neoplasm Proteins - chemistry Neoplasm Proteins - metabolism Proto-Oncogene Proteins - metabolism Recombinant Proteins - metabolism RNA - biosynthesis RNA, Small Interfering - metabolism Signal Transduction Trans-Activators Wnt Proteins Xenopus Xenopus - embryology Xenopus - genetics Xenopus Proteins - chemistry Xenopus Proteins - metabolism
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