Relationship between first polar body morphology before intracytoplasmic sperm injection and fertilization rate, cleavage rate, and embryo quality
Abstract Objectives To evaluate the influence of the morphology of the first polar body (PB) on intracytoplasmic sperm injection (ICSI) outcomes. Methods The morphology of the first PB was assessed in 3177 metaphase II oocytes and classified as: intact and normal size, fragmented, or enlarged size....
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| Veröffentlicht in: | International journal of gynecology and obstetrics 2009-03, Vol.104 (3), p.226-229 |
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| container_title | International journal of gynecology and obstetrics |
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| creator | Navarro, Paula Andrea de Araújo, Maria Medeiros de Araújo, Carlos Medeiros Rocha, Marcelo dos Reis, Rosana Martins, Wellington |
| description | Abstract Objectives To evaluate the influence of the morphology of the first polar body (PB) on intracytoplasmic sperm injection (ICSI) outcomes. Methods The morphology of the first PB was assessed in 3177 metaphase II oocytes and classified as: intact and normal size, fragmented, or enlarged size. The rates of fertilization, cleavage, and embryo quality were evaluated on day 2. Results The rates of fertilization, cleavage, and formation of good quality embryos resulting from the insemination of oocytes with an enlarged first PB (20.7%, 18.7%, and 5.0%, respectively) were significantly lower than those for oocytes with an intact first PB of normal size (70.8%, 62.5%, and 19%, respectively) or a fragmented first PB (69.7%, 60.5%, and 17.1%, respectively). Rates did not differ significantly between oocytes with an intact first PB of normal size and oocytes with a fragmented first PB ( P > 0.05). Conclusions The presence of an enlarged PB is related to poorer rates of fertilization, cleavage, and top quality embryos. However, identification of first PB fragmentation does not seem to interfere with ICSI outcomes. |
| doi_str_mv | 10.1016/j.ijgo.2008.11.008 |
| format | Article |
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Methods The morphology of the first PB was assessed in 3177 metaphase II oocytes and classified as: intact and normal size, fragmented, or enlarged size. The rates of fertilization, cleavage, and embryo quality were evaluated on day 2. Results The rates of fertilization, cleavage, and formation of good quality embryos resulting from the insemination of oocytes with an enlarged first PB (20.7%, 18.7%, and 5.0%, respectively) were significantly lower than those for oocytes with an intact first PB of normal size (70.8%, 62.5%, and 19%, respectively) or a fragmented first PB (69.7%, 60.5%, and 17.1%, respectively). Rates did not differ significantly between oocytes with an intact first PB of normal size and oocytes with a fragmented first PB ( P > 0.05). Conclusions The presence of an enlarged PB is related to poorer rates of fertilization, cleavage, and top quality embryos. However, identification of first PB fragmentation does not seem to interfere with ICSI outcomes.</description><identifier>ISSN: 0020-7292</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1016/j.ijgo.2008.11.008</identifier><identifier>PMID: 19105998</identifier><identifier>CODEN: IJGOAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Assisted reproduction outcome ; Biological and medical sciences ; Cleavage Stage, Ovum - cytology ; Cleavage Stage, Ovum - physiology ; Embryo quality ; Embryo, Mammalian - physiology ; Embryonic Development ; Female ; Fertilization ; Fertilization rate ; First polar body ; Gynecology. Andrology. Obstetrics ; Humans ; Intracytoplasmic sperm injection ; Longitudinal Studies ; Male ; Medical sciences ; Meiosis ; Microscopy ; Obstetrics and Gynecology ; Oocyte quality ; Oocytes - cytology ; Oocytes - physiology ; Pregnancy ; Pregnancy Rate ; Retrospective Studies ; Sperm Injections, Intracytoplasmic - methods</subject><ispartof>International journal of gynecology and obstetrics, 2009-03, Vol.104 (3), p.226-229</ispartof><rights>International Federation of Gynecology and Obstetrics</rights><rights>2008 International Federation of Gynecology and Obstetrics</rights><rights>2009 International Federation of Gynecology and Obstetrics</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4876-3ea9858b39d93bd5989ce6b45ea4b9d9858d3fd3462f4a5438cda48aaded865c3</citedby><cites>FETCH-LOGICAL-c4876-3ea9858b39d93bd5989ce6b45ea4b9d9858d3fd3462f4a5438cda48aaded865c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.ijgo.2008.11.008$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.ijgo.2008.11.008$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21279044$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19105998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Navarro, Paula Andrea</creatorcontrib><creatorcontrib>de Araújo, Maria Medeiros</creatorcontrib><creatorcontrib>de Araújo, Carlos Medeiros</creatorcontrib><creatorcontrib>Rocha, Marcelo</creatorcontrib><creatorcontrib>dos Reis, Rosana</creatorcontrib><creatorcontrib>Martins, Wellington</creatorcontrib><title>Relationship between first polar body morphology before intracytoplasmic sperm injection and fertilization rate, cleavage rate, and embryo quality</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description>Abstract Objectives To evaluate the influence of the morphology of the first polar body (PB) on intracytoplasmic sperm injection (ICSI) outcomes. Methods The morphology of the first PB was assessed in 3177 metaphase II oocytes and classified as: intact and normal size, fragmented, or enlarged size. The rates of fertilization, cleavage, and embryo quality were evaluated on day 2. Results The rates of fertilization, cleavage, and formation of good quality embryos resulting from the insemination of oocytes with an enlarged first PB (20.7%, 18.7%, and 5.0%, respectively) were significantly lower than those for oocytes with an intact first PB of normal size (70.8%, 62.5%, and 19%, respectively) or a fragmented first PB (69.7%, 60.5%, and 17.1%, respectively). Rates did not differ significantly between oocytes with an intact first PB of normal size and oocytes with a fragmented first PB ( P > 0.05). Conclusions The presence of an enlarged PB is related to poorer rates of fertilization, cleavage, and top quality embryos. However, identification of first PB fragmentation does not seem to interfere with ICSI outcomes.</description><subject>Assisted reproduction outcome</subject><subject>Biological and medical sciences</subject><subject>Cleavage Stage, Ovum - cytology</subject><subject>Cleavage Stage, Ovum - physiology</subject><subject>Embryo quality</subject><subject>Embryo, Mammalian - physiology</subject><subject>Embryonic Development</subject><subject>Female</subject><subject>Fertilization</subject><subject>Fertilization rate</subject><subject>First polar body</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Intracytoplasmic sperm injection</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meiosis</subject><subject>Microscopy</subject><subject>Obstetrics and Gynecology</subject><subject>Oocyte quality</subject><subject>Oocytes - cytology</subject><subject>Oocytes - physiology</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Retrospective Studies</subject><subject>Sperm Injections, Intracytoplasmic - methods</subject><issn>0020-7292</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQhiMEokvhD3BAvsCJXWzny5YQEqqgFFWqxMfZmtiTrYMTp3bSKvwMfjEOuwKJA-I08vh5Z-x5J8ueMrpjlFWvup3t9n7HKRU7xnYp3Ms2TNRymxe1vJ9tKOV0W3PJT7JHMXaUUlYz9jA7YZLRUkqxyX58QgeT9UO8tiNpcLpDHEhrQ5zI6B0E0nizkN6H8do7v18S0_qAxA5TAL1MfnQQe6tJHDH0Kd2hXusRGAxpMUzW2e-_OpAAE74k2iHcwh6PxxXDvgmLJzczODstj7MHLbiIT47xNPv6_t2Xsw_by6vzi7O3l1tdiLra5ghSlKLJpZF5Y0oppMaqKUqEokm5dGfy1uRFxdsCyiIX2kAhAAwaUZU6P81eHOqOwd_MGCfV26jRORjQz1FVlUyNWJ5AfgB18DEGbNUYbA9hUYyq1QnVqdUJtTqhGFMpJNGzY_W56dH8kRxHn4DnRwCiBtcGGLSNvznOeC1pUSSuPnB31uHyH63VxcfzK86rpHx9UGKa4q3FoKK2OGg0NiSTlPH23z9485dcOzvY9NZvuGDs_ByG5I9iKnJF1ed129Zlo4LSkkqe_wSjctGd</recordid><startdate>200903</startdate><enddate>200903</enddate><creator>Navarro, Paula Andrea</creator><creator>de Araújo, Maria Medeiros</creator><creator>de Araújo, Carlos Medeiros</creator><creator>Rocha, Marcelo</creator><creator>dos Reis, Rosana</creator><creator>Martins, Wellington</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200903</creationdate><title>Relationship between first polar body morphology before intracytoplasmic sperm injection and fertilization rate, cleavage rate, and embryo quality</title><author>Navarro, Paula Andrea ; de Araújo, Maria Medeiros ; de Araújo, Carlos Medeiros ; Rocha, Marcelo ; dos Reis, Rosana ; Martins, Wellington</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4876-3ea9858b39d93bd5989ce6b45ea4b9d9858d3fd3462f4a5438cda48aaded865c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Assisted reproduction outcome</topic><topic>Biological and medical sciences</topic><topic>Cleavage Stage, Ovum - cytology</topic><topic>Cleavage Stage, Ovum - physiology</topic><topic>Embryo quality</topic><topic>Embryo, Mammalian - physiology</topic><topic>Embryonic Development</topic><topic>Female</topic><topic>Fertilization</topic><topic>Fertilization rate</topic><topic>First polar body</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Intracytoplasmic sperm injection</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Meiosis</topic><topic>Microscopy</topic><topic>Obstetrics and Gynecology</topic><topic>Oocyte quality</topic><topic>Oocytes - cytology</topic><topic>Oocytes - physiology</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Retrospective Studies</topic><topic>Sperm Injections, Intracytoplasmic - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Navarro, Paula Andrea</creatorcontrib><creatorcontrib>de Araújo, Maria Medeiros</creatorcontrib><creatorcontrib>de Araújo, Carlos Medeiros</creatorcontrib><creatorcontrib>Rocha, Marcelo</creatorcontrib><creatorcontrib>dos Reis, Rosana</creatorcontrib><creatorcontrib>Martins, Wellington</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Navarro, Paula Andrea</au><au>de Araújo, Maria Medeiros</au><au>de Araújo, Carlos Medeiros</au><au>Rocha, Marcelo</au><au>dos Reis, Rosana</au><au>Martins, Wellington</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between first polar body morphology before intracytoplasmic sperm injection and fertilization rate, cleavage rate, and embryo quality</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>2009-03</date><risdate>2009</risdate><volume>104</volume><issue>3</issue><spage>226</spage><epage>229</epage><pages>226-229</pages><issn>0020-7292</issn><eissn>1879-3479</eissn><coden>IJGOAL</coden><abstract>Abstract Objectives To evaluate the influence of the morphology of the first polar body (PB) on intracytoplasmic sperm injection (ICSI) outcomes. Methods The morphology of the first PB was assessed in 3177 metaphase II oocytes and classified as: intact and normal size, fragmented, or enlarged size. The rates of fertilization, cleavage, and embryo quality were evaluated on day 2. Results The rates of fertilization, cleavage, and formation of good quality embryos resulting from the insemination of oocytes with an enlarged first PB (20.7%, 18.7%, and 5.0%, respectively) were significantly lower than those for oocytes with an intact first PB of normal size (70.8%, 62.5%, and 19%, respectively) or a fragmented first PB (69.7%, 60.5%, and 17.1%, respectively). Rates did not differ significantly between oocytes with an intact first PB of normal size and oocytes with a fragmented first PB ( P > 0.05). Conclusions The presence of an enlarged PB is related to poorer rates of fertilization, cleavage, and top quality embryos. However, identification of first PB fragmentation does not seem to interfere with ICSI outcomes.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19105998</pmid><doi>10.1016/j.ijgo.2008.11.008</doi><tpages>4</tpages></addata></record> |
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| ispartof | International journal of gynecology and obstetrics, 2009-03, Vol.104 (3), p.226-229 |
| issn | 0020-7292 1879-3479 |
| language | eng |
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| subjects | Assisted reproduction outcome Biological and medical sciences Cleavage Stage, Ovum - cytology Cleavage Stage, Ovum - physiology Embryo quality Embryo, Mammalian - physiology Embryonic Development Female Fertilization Fertilization rate First polar body Gynecology. Andrology. Obstetrics Humans Intracytoplasmic sperm injection Longitudinal Studies Male Medical sciences Meiosis Microscopy Obstetrics and Gynecology Oocyte quality Oocytes - cytology Oocytes - physiology Pregnancy Pregnancy Rate Retrospective Studies Sperm Injections, Intracytoplasmic - methods |
| title | Relationship between first polar body morphology before intracytoplasmic sperm injection and fertilization rate, cleavage rate, and embryo quality |
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