Protection of transplant-induced renal ischemia-reperfusion injury with carbon monoxide

Carbon monoxide (CO), a product of heme metabolism by heme oxygenases, is known to impart protection against oxidative stress. We hypothesized that CO would protect ischemia-reperfusion (I/R) injury of transplanted organs, and the efficacy of CO was studied in the rat kidney transplantation model. A...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2004-11, Vol.287 (5), p.F979-F989
Hauptverfasser:	Neto, Joao Seda, Nakao, Atsunori, Kimizuka, Kei, Romanosky, Anna Jeanine, Stolz, Donna B, Uchiyama, Takashi, Nalesnik, Michael A, Otterbein, Leo E, Murase, Noriko
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - biosynthesis Administration, Inhalation Animals Apoptosis - drug effects Blotting, Western Carbon Monoxide - administration & dosage Carbon Monoxide - therapeutic use Carboxyhemoglobin - metabolism Gene Expression Regulation - drug effects Graft Survival - drug effects Heme Oxygenase (Decyclizing) - metabolism Heme Oxygenase-1 Immunohistochemistry Inflammation Mediators Interleukin-6 - biosynthesis Kidney - drug effects Kidney - physiology Kidney Diseases - prevention & control Kidney Function Tests Kidney Transplantation - physiology Male Microscopy, Electron Nitrates - metabolism Nitrites - metabolism Rats Rats, Inbred Lew Renal Circulation - drug effects Reperfusion Injury - prevention & control Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics Transplantation, Isogeneic
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