Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase

The ubiquitous enzyme dUTP nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and can be considered as the first line of defence against incorporation of uracil into DNA. Inhibition of this enzyme results in over-incorporation of uracil into DNA, leading to DNA fragmentation and...

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Veröffentlicht in:	European journal of medicinal chemistry 2009-02, Vol.44 (2), p.678-688
Hauptverfasser:	McCarthy, Orla, Musso-Buendia, Alex, Kaiser, Marcel, Brun, Reto, Ruiz-Perez, Luis M., Johansson, Nils Gunnar, Pacanowska, Dolores Gonzalez, Gilbert, Ian H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides Animals Anti-malarial Anti-plasmodial Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Biological and medical sciences Drug Design dUTP nucleotidohydrolase Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Medical sciences Pharmacology. Drug treatments Plasmodium falciparum - drug effects Plasmodium falciparum - enzymology Plasmodium falciparum - growth & development Pyrophosphatases - antagonists & inhibitors Structure-Activity Relationship Uracil - analogs & derivatives Uracil - chemical synthesis Uracil - pharmacology Uracil acetamide
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