Elevated Plasma Ghrelin Level in Underweight Patients with Chronic Obstructive Pulmonary Disease
Ghrelin, a novel growth hormone-releasing peptide, has been shown to cause a positive energy balance by reducing fat use and stimulating food intake. This study investigated whether plasma ghrelin is associated with clinical parameters in patients with chronic obstructive pulmonary disease. Plasma g...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2004-10, Vol.170 (8), p.879-882 |
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| creator | Itoh, Takefumi Nagaya, Noritoshi Yoshikawa, Masanori Fukuoka, Atsuhiko Takenaka, Hideaki Shimizu, Yoshito Haruta, Yoshinori Oya, Hideo Yamagishi, Masakazu Hosoda, Hiroshi Kangawa, Kenji Kimura, Hiroshi |
| description | Ghrelin, a novel growth hormone-releasing peptide, has been shown to cause a positive energy balance by reducing fat use and stimulating food intake. This study investigated whether plasma ghrelin is associated with clinical parameters in patients with chronic obstructive pulmonary disease. Plasma ghrelin was measured in 50 patients and 13 control subjects, together with anabolic and catabolic factors. Patients were divided into two groups based on body mass index: underweight patients (n = 26) or normal weight patients (n = 24). Plasma ghrelin was significantly higher in underweight patients than in normal weight patients and healthy control subjects. Circulating tumor necrosis factor-alpha, interleukin-6, and norepinephrine were significantly higher in underweight patients than in normal weight patients. Plasma ghrelin correlated negatively with body mass index and correlated positively with catabolic factors such as tumor necrosis factor-alpha and norepinephrine. In addition, plasma ghrelin correlated positively with percent predicted residual volume and residual volume-to-total lung capacity ratio. In conclusion, plasma ghrelin was elevated in underweight patients with chronic obstructive pulmonary disease, and the level was associated with a cachectic state and abnormality of pulmonary function. |
| doi_str_mv | 10.1164/rccm.200310-1404OC |
| format | Article |
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This study investigated whether plasma ghrelin is associated with clinical parameters in patients with chronic obstructive pulmonary disease. Plasma ghrelin was measured in 50 patients and 13 control subjects, together with anabolic and catabolic factors. Patients were divided into two groups based on body mass index: underweight patients (n = 26) or normal weight patients (n = 24). Plasma ghrelin was significantly higher in underweight patients than in normal weight patients and healthy control subjects. Circulating tumor necrosis factor-alpha, interleukin-6, and norepinephrine were significantly higher in underweight patients than in normal weight patients. Plasma ghrelin correlated negatively with body mass index and correlated positively with catabolic factors such as tumor necrosis factor-alpha and norepinephrine. In addition, plasma ghrelin correlated positively with percent predicted residual volume and residual volume-to-total lung capacity ratio. In conclusion, plasma ghrelin was elevated in underweight patients with chronic obstructive pulmonary disease, and the level was associated with a cachectic state and abnormality of pulmonary function.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/rccm.200310-1404OC</identifier><identifier>PMID: 15271696</identifier><language>eng</language><publisher>New York, NY: Am Thoracic Soc</publisher><subject>Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Body Mass Index ; Body Weight ; Cachexia - physiopathology ; Case-Control Studies ; Chronic obstructive pulmonary disease ; Chronic obstructive pulmonary disease, asthma ; Cytokines ; Energy Metabolism ; Female ; Ghrelin ; Growth Hormone - blood ; Growth hormones ; Humans ; Insulin-like growth factors ; Intensive care medicine ; Male ; Medical sciences ; Peptide Hormones - blood ; Peptides ; Plasma ; Pneumology ; Proteins ; Pulmonary Disease, Chronic Obstructive - blood ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases ; Respiratory Function Tests ; Tumor necrosis factor-TNF ; Variance analysis</subject><ispartof>American journal of respiratory and critical care medicine, 2004-10, Vol.170 (8), p.879-882</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright American Thoracic Society Oct 15, 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-2f8c4c1aa16c91773b90b9a5a6650ecba26675654f3d4b8fa23ecb2f19bd1d083</citedby><cites>FETCH-LOGICAL-c390t-2f8c4c1aa16c91773b90b9a5a6650ecba26675654f3d4b8fa23ecb2f19bd1d083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4011,4012,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16171216$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15271696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Itoh, Takefumi</creatorcontrib><creatorcontrib>Nagaya, Noritoshi</creatorcontrib><creatorcontrib>Yoshikawa, Masanori</creatorcontrib><creatorcontrib>Fukuoka, Atsuhiko</creatorcontrib><creatorcontrib>Takenaka, Hideaki</creatorcontrib><creatorcontrib>Shimizu, Yoshito</creatorcontrib><creatorcontrib>Haruta, Yoshinori</creatorcontrib><creatorcontrib>Oya, Hideo</creatorcontrib><creatorcontrib>Yamagishi, Masakazu</creatorcontrib><creatorcontrib>Hosoda, Hiroshi</creatorcontrib><creatorcontrib>Kangawa, Kenji</creatorcontrib><creatorcontrib>Kimura, Hiroshi</creatorcontrib><title>Elevated Plasma Ghrelin Level in Underweight Patients with Chronic Obstructive Pulmonary Disease</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>Ghrelin, a novel growth hormone-releasing peptide, has been shown to cause a positive energy balance by reducing fat use and stimulating food intake. This study investigated whether plasma ghrelin is associated with clinical parameters in patients with chronic obstructive pulmonary disease. Plasma ghrelin was measured in 50 patients and 13 control subjects, together with anabolic and catabolic factors. Patients were divided into two groups based on body mass index: underweight patients (n = 26) or normal weight patients (n = 24). Plasma ghrelin was significantly higher in underweight patients than in normal weight patients and healthy control subjects. Circulating tumor necrosis factor-alpha, interleukin-6, and norepinephrine were significantly higher in underweight patients than in normal weight patients. Plasma ghrelin correlated negatively with body mass index and correlated positively with catabolic factors such as tumor necrosis factor-alpha and norepinephrine. In addition, plasma ghrelin correlated positively with percent predicted residual volume and residual volume-to-total lung capacity ratio. In conclusion, plasma ghrelin was elevated in underweight patients with chronic obstructive pulmonary disease, and the level was associated with a cachectic state and abnormality of pulmonary function.</description><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Body Weight</subject><subject>Cachexia - physiopathology</subject><subject>Case-Control Studies</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Cytokines</subject><subject>Energy Metabolism</subject><subject>Female</subject><subject>Ghrelin</subject><subject>Growth Hormone - blood</subject><subject>Growth hormones</subject><subject>Humans</subject><subject>Insulin-like growth factors</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Peptide Hormones - blood</subject><subject>Peptides</subject><subject>Plasma</subject><subject>Pneumology</subject><subject>Proteins</subject><subject>Pulmonary Disease, Chronic Obstructive - blood</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Pulmonary hypertension. 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Pulmonary vascular diseases</subject><subject>Respiratory Function Tests</subject><subject>Tumor necrosis factor-TNF</subject><subject>Variance analysis</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkU1r3DAQhk1paT7aP9BDEYUGenCisWTJOpZNmhYWdg8J9KbK8rjWItupZO_Sfx9tvRDoSYN45p3Royz7APQaQPCbYG1_XVDKgObAKd-sXmXnULIy50rS16mmkuWcq59n2UWMO0qhqIC-zc6gLCQIJc6zX3ce92bChmy9ib0h911A7wayxj16korHocFwQPe7m8jWTA6HKZKDmzqy6sI4OEs2dZzCbCe3R7KdfT8OJvwlty6iifgue9MaH_H96bzMHr_dPay-5-vN_Y_V13VumaJTXrSV5RaMAWEVSMlqRWtlSiNESdHWphBClqLkLWt4XbWmYOm2aEHVDTS0YpfZ1ZL7FMY_M8ZJ9y5a9N4MOM5RC6G4ZOUR_PQfuBvnMKTdNCglmFQgElQskA1jjAFb_RRcn56lgeqjfH2Urxf5epGfmj6ekue6x-al5WQ7AZ9PgInW-DaYwbr4wgmQUPyb_mXhumT94ALq9DPep1jQZnecDJLqSldSsWcMgZyF</recordid><startdate>20041015</startdate><enddate>20041015</enddate><creator>Itoh, Takefumi</creator><creator>Nagaya, Noritoshi</creator><creator>Yoshikawa, Masanori</creator><creator>Fukuoka, Atsuhiko</creator><creator>Takenaka, Hideaki</creator><creator>Shimizu, Yoshito</creator><creator>Haruta, Yoshinori</creator><creator>Oya, Hideo</creator><creator>Yamagishi, Masakazu</creator><creator>Hosoda, Hiroshi</creator><creator>Kangawa, Kenji</creator><creator>Kimura, Hiroshi</creator><general>Am Thoracic Soc</general><general>American Lung Association</general><general>American Thoracic Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20041015</creationdate><title>Elevated Plasma Ghrelin Level in Underweight Patients with Chronic Obstructive Pulmonary Disease</title><author>Itoh, Takefumi ; Nagaya, Noritoshi ; Yoshikawa, Masanori ; Fukuoka, Atsuhiko ; Takenaka, Hideaki ; Shimizu, Yoshito ; Haruta, Yoshinori ; Oya, Hideo ; Yamagishi, Masakazu ; Hosoda, Hiroshi ; Kangawa, Kenji ; Kimura, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-2f8c4c1aa16c91773b90b9a5a6650ecba26675654f3d4b8fa23ecb2f19bd1d083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Body Weight</topic><topic>Cachexia - physiopathology</topic><topic>Case-Control Studies</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Cytokines</topic><topic>Energy Metabolism</topic><topic>Female</topic><topic>Ghrelin</topic><topic>Growth Hormone - blood</topic><topic>Growth hormones</topic><topic>Humans</topic><topic>Insulin-like growth factors</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Peptide Hormones - blood</topic><topic>Peptides</topic><topic>Plasma</topic><topic>Pneumology</topic><topic>Proteins</topic><topic>Pulmonary Disease, Chronic Obstructive - blood</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Pulmonary hypertension. Acute cor pulmonale. 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This study investigated whether plasma ghrelin is associated with clinical parameters in patients with chronic obstructive pulmonary disease. Plasma ghrelin was measured in 50 patients and 13 control subjects, together with anabolic and catabolic factors. Patients were divided into two groups based on body mass index: underweight patients (n = 26) or normal weight patients (n = 24). Plasma ghrelin was significantly higher in underweight patients than in normal weight patients and healthy control subjects. Circulating tumor necrosis factor-alpha, interleukin-6, and norepinephrine were significantly higher in underweight patients than in normal weight patients. Plasma ghrelin correlated negatively with body mass index and correlated positively with catabolic factors such as tumor necrosis factor-alpha and norepinephrine. In addition, plasma ghrelin correlated positively with percent predicted residual volume and residual volume-to-total lung capacity ratio. In conclusion, plasma ghrelin was elevated in underweight patients with chronic obstructive pulmonary disease, and the level was associated with a cachectic state and abnormality of pulmonary function.</abstract><cop>New York, NY</cop><pub>Am Thoracic Soc</pub><pmid>15271696</pmid><doi>10.1164/rccm.200310-1404OC</doi><tpages>4</tpages></addata></record> |
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| ispartof | American journal of respiratory and critical care medicine, 2004-10, Vol.170 (8), p.879-882 |
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| source | MEDLINE; American Thoracic Society (ATS) Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Body Mass Index Body Weight Cachexia - physiopathology Case-Control Studies Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease, asthma Cytokines Energy Metabolism Female Ghrelin Growth Hormone - blood Growth hormones Humans Insulin-like growth factors Intensive care medicine Male Medical sciences Peptide Hormones - blood Peptides Plasma Pneumology Proteins Pulmonary Disease, Chronic Obstructive - blood Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Respiratory Function Tests Tumor necrosis factor-TNF Variance analysis |
| title | Elevated Plasma Ghrelin Level in Underweight Patients with Chronic Obstructive Pulmonary Disease |
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