The chemokine CXCL10 modulates excitatory activity and intracellular calcium signaling in cultured hippocampal neurons

In this study, we provide evidence for direct modulatory effects of the chemokine, CXCL10, on the physiology of hippocampal neurons maintained in primary culture. CXCL10 elicited a rise in intracellular Ca 2+ and enhanced both spontaneous and evoked electrical activity of hippocampal neurons. CXCL10...

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Veröffentlicht in:	Journal of neuroimmunology 2004-11, Vol.156 (1), p.74-87
Hauptverfasser:	Nelson, Thomas E., Gruol, Donna L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - immunology Animals Calcium imaging Calcium Signaling - immunology Cells, Cultured Chemokine Chemokine CXCL10 Chemokines, CXC Cytokines - physiology Hippocampus - cytology Hippocampus - immunology Hippocampus - physiology Immunohistochemistry Intracellular calcium IP-10 Neurons - immunology Neurons - physiology Rat Rats Rats, Sprague-Dawley Receptors, Chemokine - biosynthesis Receptors, CXCR3
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