Phospho-regulation of synaptic and extrasynaptic N -methyl- d -aspartate receptors in adult hippocampal slices

Abstract Recent evidence demonstrates that N -methyl- d -aspartate receptor (NMDAR) trafficking contributes to synaptic plasticity in the hippocampus. Phosphorylation of tyrosine residues, especially NR2B tyrosine 1472, appears to be a mechanism by which NMDAR endocytosis is prevented, suggesting th...

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Veröffentlicht in:	Neuroscience 2009-02, Vol.158 (4), p.1446-1459
Hauptverfasser:	Goebel-Goody, S.M, Davies, K.D, Alvestad Linger, R.M, Freund, R.K, Browning, M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bicuculline - pharmacology Biological and medical sciences Biophysical Phenomena detergent extraction electrophysiology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Fundamental and applied biological sciences. Psychology GABA Antagonists - pharmacology Glutamic Acid - metabolism Hippocampus - cytology Immunoprecipitation - methods In Vitro Techniques long-term potentiation Male Neurology Neuronal Plasticity - physiology Neurons - drug effects Neurons - metabolism Organometallic Compounds - pharmacology Patch-Clamp Techniques Phenanthrolines - pharmacology Phosphorylation - drug effects Protein Subunits - metabolism Protein Transport Protein Tyrosine Phosphatases - antagonists & inhibitors Quinoxalines - pharmacology Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Subcellular Fractions - metabolism Subcellular Fractions - ultrastructure Synapses - physiology Synapses - ultrastructure trafficking Triton X-100 Tyrosine - metabolism tyrosine phosphorylation Vertebrates: nervous system and sense organs
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