Gastroesophageal Reflux and Pulmonary Fibrosis in Scleroderma: A Study Using pH-Impedance Monitoring
Interstitial lung disease (ILD) in patients with systemic sclerosis (SSc) is associated with increased morbidity and mortality. Gastroesophageal reflux (GER) is considered a contributing factor in the pathogenesis of ILD. To characterize GER (acid and nonacid) in patients with SSc with and without I...
Gespeichert in:
| Veröffentlicht in: | American journal of respiratory and critical care medicine 2009-03, Vol.179 (5), p.408-413 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 413 |
|---|---|
| container_issue | 5 |
| container_start_page | 408 |
| container_title | American journal of respiratory and critical care medicine |
| container_volume | 179 |
| creator | Savarino, Edoardo Bazzica, Marco Zentilin, Patrizia Pohl, Daniel Parodi, Andrea Cittadini, Giuseppe Negrini, Simone Indiveri, Francesco Tutuian, Radu Savarino, Vincenzo Ghio, Massimo |
| description | Interstitial lung disease (ILD) in patients with systemic sclerosis (SSc) is associated with increased morbidity and mortality. Gastroesophageal reflux (GER) is considered a contributing factor in the pathogenesis of ILD.
To characterize GER (acid and nonacid) in patients with SSc with and without ILD.
Patients with SSc underwent pulmonary high-resolution computer tomography (HRCT) scan and 24-hour impedance-pH monitoring off-proton pump inhibitor therapy. The presence of pulmonary fibrosis was assessed using validated HRCT-scores. Reflux monitoring parameters included number of acid and nonacid reflux episodes, proximal migration of the refluxate, and distal esophageal acid exposure. Unless otherwise specified, data are presented as median (25th-75th percentile).
Forty consecutive patients with SSc (35 female; mean age, 53 yr; range, 24-71; 15 patients with diffuse and 25 with limited SSc) were investigated; 18 (45%) patients with SSc had pulmonary fibrosis (HRCT score >or= 7). Patients with SSc with ILD had higher (P < 0.01) esophageal acid exposure (10.3 [7.5-15] vs. 5.2 [1.5-11]), higher (P < 0.01) number of acid (41 [31-58] vs. 19 [10-23]) and nonacid (25 [20-35] vs. 17 [11-19]) reflux episodes, and higher (P < 0.01) number of reflux episodes reaching the proximal esophagus (42.5 [31-54] vs. 15 [8-22]) compared with patients with SSc with normal HRCT scores. Pulmonary fibrosis scores (HRCT score) correlated well with the number of reflux episodes in the distal (r(2) = 0.637) and proximal (r(2) = 0.644) esophagus.
Patients with SSc with ILD have more severe reflux (i.e., more reflux episodes and more reflux reaching the proximal esophagus). Whether or not the development of ILD in patients with SSc can be prevented by reflux-reducing treatments needs to be investigated. |
| doi_str_mv | 10.1164/rccm.200808-1359OC |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66944424</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1651339481</sourcerecordid><originalsourceid>FETCH-LOGICAL-c258t-95d3869a2687b3e5e2cfd29c7a7d2b50ee3ed89b3b74aad48f9f260b5d6e42253</originalsourceid><addsrcrecordid>eNpdkV2L1DAYhYso7rr6B7yQICh40TXfbbxbBvcDVlZcF7wLafJ2JkPa1KRF99-boYOCV294ec5Jck5VvSb4nBDJPyZrh3OKcYvbmjCh7jZPqlMimKi5avDTcsYNqzlXP06qFznvMSa0Jfh5dUIUVhJjflq5K5PnFCHHaWe2YAL6Bn1YfiMzOvR1CUMcTXpEl75LMfuM_IjubYAUHaTBfEIX6H5e3CN6yH7coum6vhkmcGa0gL7E0c8xlf3L6llvQoZXx3lWPVx-_r65rm_vrm42F7e1paKdayUca6UyVLZNx0AAtb2jyjamcbQTGICBa1XHuoYb43jbq55K3AkngVMq2Fn1fvWdUvy5QJ714LOFEMwIcclaSsU5p7yAb_8D93FJY3mbJkpJUkKVBaIrZMvXc4JeT8kPJQ1NsD4UoA8F6LUAvRZQRG-Ozks3gPsnOSZegHdHwGRrQp9KVj7_5SihtGHswH1YuZ3f7n75BDoPJoRiS7TZH24mjdJCc9yyP8BcncU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>199612006</pqid></control><display><type>article</type><title>Gastroesophageal Reflux and Pulmonary Fibrosis in Scleroderma: A Study Using pH-Impedance Monitoring</title><source>MEDLINE</source><source>American Thoracic Society Journals</source><source>Journals@Ovid Ovid Autoload</source><source>Free E-Journal (出版社公開部分のみ）</source><source>Alma/SFX Local Collection</source><creator>Savarino, Edoardo ; Bazzica, Marco ; Zentilin, Patrizia ; Pohl, Daniel ; Parodi, Andrea ; Cittadini, Giuseppe ; Negrini, Simone ; Indiveri, Francesco ; Tutuian, Radu ; Savarino, Vincenzo ; Ghio, Massimo</creator><creatorcontrib>Savarino, Edoardo ; Bazzica, Marco ; Zentilin, Patrizia ; Pohl, Daniel ; Parodi, Andrea ; Cittadini, Giuseppe ; Negrini, Simone ; Indiveri, Francesco ; Tutuian, Radu ; Savarino, Vincenzo ; Ghio, Massimo</creatorcontrib><description>Interstitial lung disease (ILD) in patients with systemic sclerosis (SSc) is associated with increased morbidity and mortality. Gastroesophageal reflux (GER) is considered a contributing factor in the pathogenesis of ILD.
To characterize GER (acid and nonacid) in patients with SSc with and without ILD.
Patients with SSc underwent pulmonary high-resolution computer tomography (HRCT) scan and 24-hour impedance-pH monitoring off-proton pump inhibitor therapy. The presence of pulmonary fibrosis was assessed using validated HRCT-scores. Reflux monitoring parameters included number of acid and nonacid reflux episodes, proximal migration of the refluxate, and distal esophageal acid exposure. Unless otherwise specified, data are presented as median (25th-75th percentile).
Forty consecutive patients with SSc (35 female; mean age, 53 yr; range, 24-71; 15 patients with diffuse and 25 with limited SSc) were investigated; 18 (45%) patients with SSc had pulmonary fibrosis (HRCT score >or= 7). Patients with SSc with ILD had higher (P < 0.01) esophageal acid exposure (10.3 [7.5-15] vs. 5.2 [1.5-11]), higher (P < 0.01) number of acid (41 [31-58] vs. 19 [10-23]) and nonacid (25 [20-35] vs. 17 [11-19]) reflux episodes, and higher (P < 0.01) number of reflux episodes reaching the proximal esophagus (42.5 [31-54] vs. 15 [8-22]) compared with patients with SSc with normal HRCT scores. Pulmonary fibrosis scores (HRCT score) correlated well with the number of reflux episodes in the distal (r(2) = 0.637) and proximal (r(2) = 0.644) esophagus.
Patients with SSc with ILD have more severe reflux (i.e., more reflux episodes and more reflux reaching the proximal esophagus). Whether or not the development of ILD in patients with SSc can be prevented by reflux-reducing treatments needs to be investigated.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/rccm.200808-1359OC</identifier><identifier>PMID: 19096004</identifier><language>eng</language><publisher>New York, NY: Am Thoracic Soc</publisher><subject>Acids ; Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Case-Control Studies ; Catheters ; Connective tissue ; Dyspnea ; Electric Impedance ; Esophageal pH Monitoring ; Esophagus ; Esophagus - pathology ; Esophagus - physiopathology ; Female ; Gastroesophageal reflux ; Gastroesophageal Reflux - complications ; Gastroesophageal Reflux - pathology ; Gastroesophageal Reflux - physiopathology ; Humans ; Intensive care medicine ; Investigations ; Lung diseases ; Lungs ; Male ; Medical sciences ; Middle Aged ; Mortality ; Motility ; Pathogenesis ; Pneumology ; Prospective Studies ; Protons ; Pulmonary fibrosis ; Pulmonary Fibrosis - complications ; Pulmonary Fibrosis - pathology ; Pulmonary Fibrosis - physiopathology ; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases ; Respiratory Function Tests ; Scleroderma ; Scleroderma, Systemic - complications ; Scleroderma, Systemic - pathology ; Scleroderma, Systemic - physiopathology ; Tomography, X-Ray Computed ; Young Adult</subject><ispartof>American journal of respiratory and critical care medicine, 2009-03, Vol.179 (5), p.408-413</ispartof><rights>2009 INIST-CNRS</rights><rights>Copyright American Thoracic Society Mar 1, 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c258t-95d3869a2687b3e5e2cfd29c7a7d2b50ee3ed89b3b74aad48f9f260b5d6e42253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,4023,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21227334$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19096004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Savarino, Edoardo</creatorcontrib><creatorcontrib>Bazzica, Marco</creatorcontrib><creatorcontrib>Zentilin, Patrizia</creatorcontrib><creatorcontrib>Pohl, Daniel</creatorcontrib><creatorcontrib>Parodi, Andrea</creatorcontrib><creatorcontrib>Cittadini, Giuseppe</creatorcontrib><creatorcontrib>Negrini, Simone</creatorcontrib><creatorcontrib>Indiveri, Francesco</creatorcontrib><creatorcontrib>Tutuian, Radu</creatorcontrib><creatorcontrib>Savarino, Vincenzo</creatorcontrib><creatorcontrib>Ghio, Massimo</creatorcontrib><title>Gastroesophageal Reflux and Pulmonary Fibrosis in Scleroderma: A Study Using pH-Impedance Monitoring</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>Interstitial lung disease (ILD) in patients with systemic sclerosis (SSc) is associated with increased morbidity and mortality. Gastroesophageal reflux (GER) is considered a contributing factor in the pathogenesis of ILD.
To characterize GER (acid and nonacid) in patients with SSc with and without ILD.
Patients with SSc underwent pulmonary high-resolution computer tomography (HRCT) scan and 24-hour impedance-pH monitoring off-proton pump inhibitor therapy. The presence of pulmonary fibrosis was assessed using validated HRCT-scores. Reflux monitoring parameters included number of acid and nonacid reflux episodes, proximal migration of the refluxate, and distal esophageal acid exposure. Unless otherwise specified, data are presented as median (25th-75th percentile).
Forty consecutive patients with SSc (35 female; mean age, 53 yr; range, 24-71; 15 patients with diffuse and 25 with limited SSc) were investigated; 18 (45%) patients with SSc had pulmonary fibrosis (HRCT score >or= 7). Patients with SSc with ILD had higher (P < 0.01) esophageal acid exposure (10.3 [7.5-15] vs. 5.2 [1.5-11]), higher (P < 0.01) number of acid (41 [31-58] vs. 19 [10-23]) and nonacid (25 [20-35] vs. 17 [11-19]) reflux episodes, and higher (P < 0.01) number of reflux episodes reaching the proximal esophagus (42.5 [31-54] vs. 15 [8-22]) compared with patients with SSc with normal HRCT scores. Pulmonary fibrosis scores (HRCT score) correlated well with the number of reflux episodes in the distal (r(2) = 0.637) and proximal (r(2) = 0.644) esophagus.
Patients with SSc with ILD have more severe reflux (i.e., more reflux episodes and more reflux reaching the proximal esophagus). Whether or not the development of ILD in patients with SSc can be prevented by reflux-reducing treatments needs to be investigated.</description><subject>Acids</subject><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Catheters</subject><subject>Connective tissue</subject><subject>Dyspnea</subject><subject>Electric Impedance</subject><subject>Esophageal pH Monitoring</subject><subject>Esophagus</subject><subject>Esophagus - pathology</subject><subject>Esophagus - physiopathology</subject><subject>Female</subject><subject>Gastroesophageal reflux</subject><subject>Gastroesophageal Reflux - complications</subject><subject>Gastroesophageal Reflux - pathology</subject><subject>Gastroesophageal Reflux - physiopathology</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Investigations</subject><subject>Lung diseases</subject><subject>Lungs</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Motility</subject><subject>Pathogenesis</subject><subject>Pneumology</subject><subject>Prospective Studies</subject><subject>Protons</subject><subject>Pulmonary fibrosis</subject><subject>Pulmonary Fibrosis - complications</subject><subject>Pulmonary Fibrosis - pathology</subject><subject>Pulmonary Fibrosis - physiopathology</subject><subject>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</subject><subject>Respiratory Function Tests</subject><subject>Scleroderma</subject><subject>Scleroderma, Systemic - complications</subject><subject>Scleroderma, Systemic - pathology</subject><subject>Scleroderma, Systemic - physiopathology</subject><subject>Tomography, X-Ray Computed</subject><subject>Young Adult</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkV2L1DAYhYso7rr6B7yQICh40TXfbbxbBvcDVlZcF7wLafJ2JkPa1KRF99-boYOCV294ec5Jck5VvSb4nBDJPyZrh3OKcYvbmjCh7jZPqlMimKi5avDTcsYNqzlXP06qFznvMSa0Jfh5dUIUVhJjflq5K5PnFCHHaWe2YAL6Bn1YfiMzOvR1CUMcTXpEl75LMfuM_IjubYAUHaTBfEIX6H5e3CN6yH7coum6vhkmcGa0gL7E0c8xlf3L6llvQoZXx3lWPVx-_r65rm_vrm42F7e1paKdayUca6UyVLZNx0AAtb2jyjamcbQTGICBa1XHuoYb43jbq55K3AkngVMq2Fn1fvWdUvy5QJ714LOFEMwIcclaSsU5p7yAb_8D93FJY3mbJkpJUkKVBaIrZMvXc4JeT8kPJQ1NsD4UoA8F6LUAvRZQRG-Ozks3gPsnOSZegHdHwGRrQp9KVj7_5SihtGHswH1YuZ3f7n75BDoPJoRiS7TZH24mjdJCc9yyP8BcncU</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Savarino, Edoardo</creator><creator>Bazzica, Marco</creator><creator>Zentilin, Patrizia</creator><creator>Pohl, Daniel</creator><creator>Parodi, Andrea</creator><creator>Cittadini, Giuseppe</creator><creator>Negrini, Simone</creator><creator>Indiveri, Francesco</creator><creator>Tutuian, Radu</creator><creator>Savarino, Vincenzo</creator><creator>Ghio, Massimo</creator><general>Am Thoracic Soc</general><general>American Thoracic Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20090301</creationdate><title>Gastroesophageal Reflux and Pulmonary Fibrosis in Scleroderma: A Study Using pH-Impedance Monitoring</title><author>Savarino, Edoardo ; Bazzica, Marco ; Zentilin, Patrizia ; Pohl, Daniel ; Parodi, Andrea ; Cittadini, Giuseppe ; Negrini, Simone ; Indiveri, Francesco ; Tutuian, Radu ; Savarino, Vincenzo ; Ghio, Massimo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c258t-95d3869a2687b3e5e2cfd29c7a7d2b50ee3ed89b3b74aad48f9f260b5d6e42253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acids</topic><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Catheters</topic><topic>Connective tissue</topic><topic>Dyspnea</topic><topic>Electric Impedance</topic><topic>Esophageal pH Monitoring</topic><topic>Esophagus</topic><topic>Esophagus - pathology</topic><topic>Esophagus - physiopathology</topic><topic>Female</topic><topic>Gastroesophageal reflux</topic><topic>Gastroesophageal Reflux - complications</topic><topic>Gastroesophageal Reflux - pathology</topic><topic>Gastroesophageal Reflux - physiopathology</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Investigations</topic><topic>Lung diseases</topic><topic>Lungs</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Motility</topic><topic>Pathogenesis</topic><topic>Pneumology</topic><topic>Prospective Studies</topic><topic>Protons</topic><topic>Pulmonary fibrosis</topic><topic>Pulmonary Fibrosis - complications</topic><topic>Pulmonary Fibrosis - pathology</topic><topic>Pulmonary Fibrosis - physiopathology</topic><topic>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</topic><topic>Respiratory Function Tests</topic><topic>Scleroderma</topic><topic>Scleroderma, Systemic - complications</topic><topic>Scleroderma, Systemic - pathology</topic><topic>Scleroderma, Systemic - physiopathology</topic><topic>Tomography, X-Ray Computed</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Savarino, Edoardo</creatorcontrib><creatorcontrib>Bazzica, Marco</creatorcontrib><creatorcontrib>Zentilin, Patrizia</creatorcontrib><creatorcontrib>Pohl, Daniel</creatorcontrib><creatorcontrib>Parodi, Andrea</creatorcontrib><creatorcontrib>Cittadini, Giuseppe</creatorcontrib><creatorcontrib>Negrini, Simone</creatorcontrib><creatorcontrib>Indiveri, Francesco</creatorcontrib><creatorcontrib>Tutuian, Radu</creatorcontrib><creatorcontrib>Savarino, Vincenzo</creatorcontrib><creatorcontrib>Ghio, Massimo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database (ProQuest)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Savarino, Edoardo</au><au>Bazzica, Marco</au><au>Zentilin, Patrizia</au><au>Pohl, Daniel</au><au>Parodi, Andrea</au><au>Cittadini, Giuseppe</au><au>Negrini, Simone</au><au>Indiveri, Francesco</au><au>Tutuian, Radu</au><au>Savarino, Vincenzo</au><au>Ghio, Massimo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastroesophageal Reflux and Pulmonary Fibrosis in Scleroderma: A Study Using pH-Impedance Monitoring</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><addtitle>Am J Respir Crit Care Med</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>179</volume><issue>5</issue><spage>408</spage><epage>413</epage><pages>408-413</pages><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>Interstitial lung disease (ILD) in patients with systemic sclerosis (SSc) is associated with increased morbidity and mortality. Gastroesophageal reflux (GER) is considered a contributing factor in the pathogenesis of ILD.
To characterize GER (acid and nonacid) in patients with SSc with and without ILD.
Patients with SSc underwent pulmonary high-resolution computer tomography (HRCT) scan and 24-hour impedance-pH monitoring off-proton pump inhibitor therapy. The presence of pulmonary fibrosis was assessed using validated HRCT-scores. Reflux monitoring parameters included number of acid and nonacid reflux episodes, proximal migration of the refluxate, and distal esophageal acid exposure. Unless otherwise specified, data are presented as median (25th-75th percentile).
Forty consecutive patients with SSc (35 female; mean age, 53 yr; range, 24-71; 15 patients with diffuse and 25 with limited SSc) were investigated; 18 (45%) patients with SSc had pulmonary fibrosis (HRCT score >or= 7). Patients with SSc with ILD had higher (P < 0.01) esophageal acid exposure (10.3 [7.5-15] vs. 5.2 [1.5-11]), higher (P < 0.01) number of acid (41 [31-58] vs. 19 [10-23]) and nonacid (25 [20-35] vs. 17 [11-19]) reflux episodes, and higher (P < 0.01) number of reflux episodes reaching the proximal esophagus (42.5 [31-54] vs. 15 [8-22]) compared with patients with SSc with normal HRCT scores. Pulmonary fibrosis scores (HRCT score) correlated well with the number of reflux episodes in the distal (r(2) = 0.637) and proximal (r(2) = 0.644) esophagus.
Patients with SSc with ILD have more severe reflux (i.e., more reflux episodes and more reflux reaching the proximal esophagus). Whether or not the development of ILD in patients with SSc can be prevented by reflux-reducing treatments needs to be investigated.</abstract><cop>New York, NY</cop><pub>Am Thoracic Soc</pub><pmid>19096004</pmid><doi>10.1164/rccm.200808-1359OC</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1073-449X |
| ispartof | American journal of respiratory and critical care medicine, 2009-03, Vol.179 (5), p.408-413 |
| issn | 1073-449X 1535-4970 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66944424 |
| source | MEDLINE; American Thoracic Society Journals; Journals@Ovid Ovid Autoload; Free E-Journal (出版社公開部分のみ）; Alma/SFX Local Collection |
| subjects | Acids Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Case-Control Studies Catheters Connective tissue Dyspnea Electric Impedance Esophageal pH Monitoring Esophagus Esophagus - pathology Esophagus - physiopathology Female Gastroesophageal reflux Gastroesophageal Reflux - complications Gastroesophageal Reflux - pathology Gastroesophageal Reflux - physiopathology Humans Intensive care medicine Investigations Lung diseases Lungs Male Medical sciences Middle Aged Mortality Motility Pathogenesis Pneumology Prospective Studies Protons Pulmonary fibrosis Pulmonary Fibrosis - complications Pulmonary Fibrosis - pathology Pulmonary Fibrosis - physiopathology Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Respiratory Function Tests Scleroderma Scleroderma, Systemic - complications Scleroderma, Systemic - pathology Scleroderma, Systemic - physiopathology Tomography, X-Ray Computed Young Adult |
| title | Gastroesophageal Reflux and Pulmonary Fibrosis in Scleroderma: A Study Using pH-Impedance Monitoring |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T14%3A35%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gastroesophageal%20Reflux%20and%20Pulmonary%20Fibrosis%20in%20Scleroderma:%20A%20Study%20Using%20pH-Impedance%20Monitoring&rft.jtitle=American%20journal%20of%20respiratory%20and%20critical%20care%20medicine&rft.au=Savarino,%20Edoardo&rft.date=2009-03-01&rft.volume=179&rft.issue=5&rft.spage=408&rft.epage=413&rft.pages=408-413&rft.issn=1073-449X&rft.eissn=1535-4970&rft_id=info:doi/10.1164/rccm.200808-1359OC&rft_dat=%3Cproquest_cross%3E1651339481%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=199612006&rft_id=info:pmid/19096004&rfr_iscdi=true |