Japanese herbal medicine Inchin-ko-to as a therapeutic drug for liver fibrosis
Inchin-ko-to (TJ-135) is an herbal medicine used in Japan for treatment of icteric patients with cirrhosis. Its efficacy as an anti-fibrogenic drug was evaluated in relation to stellate cell activation. Liver fibrosis was induced in rats by repeated injections of carbon tetrachloride (CCl 4) or pig-...
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| Veröffentlicht in: | Journal of hepatology 2004-10, Vol.41 (4), p.584-591 |
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| creator | Inao, Mie Mochida, Satoshi Matsui, Atsushi Eguchi, Yuichiro Yulutuz, Yusufu Wang, Yanhong Naiki, Kayoko Kakinuma, Tohru Fujimori, Kenji Nagoshi, Sumiko Fujiwara, Kenji |
| description | Inchin-ko-to (TJ-135) is an herbal medicine used in Japan for treatment of icteric patients with cirrhosis. Its efficacy as an anti-fibrogenic drug was evaluated in relation to stellate cell activation.
Liver fibrosis was induced in rats by repeated injections of carbon tetrachloride (CCl
4) or pig-serum. Oral administration of TJ-135 improved the mortality of rats given CCl
4 with reduced extents of liver necrosis and fibrosis. Similar improvement of liver fibrosis was found in rats given pig-serum showing no liver necrosis.
DNA synthesis of stellate cells activated in vitro after isolation from normal rat liver was decreased by culture with TJ-135 in a dose-related manner, accompanied by decreased smooth muscle α actin expression and contractility. Such attenuation was not found in the cells cultured with geniposide, an iridoid compound of TJ-135, but genipin, an aglycone of geniposide formed in the gut by action of bacterial flora, markedly decreased stellate cell activation without affecting synthesis of proteins other than collagen.
TJ-135 may be useful for treatment of liver fibrosis and portal hypertension through suppression of activated hepatic stellate cell function by genipin, an absorbed form of its component. |
| doi_str_mv | 10.1016/j.jhep.2004.06.033 |
| format | Article |
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Liver fibrosis was induced in rats by repeated injections of carbon tetrachloride (CCl
4) or pig-serum. Oral administration of TJ-135 improved the mortality of rats given CCl
4 with reduced extents of liver necrosis and fibrosis. Similar improvement of liver fibrosis was found in rats given pig-serum showing no liver necrosis.
DNA synthesis of stellate cells activated in vitro after isolation from normal rat liver was decreased by culture with TJ-135 in a dose-related manner, accompanied by decreased smooth muscle α actin expression and contractility. Such attenuation was not found in the cells cultured with geniposide, an iridoid compound of TJ-135, but genipin, an aglycone of geniposide formed in the gut by action of bacterial flora, markedly decreased stellate cell activation without affecting synthesis of proteins other than collagen.
TJ-135 may be useful for treatment of liver fibrosis and portal hypertension through suppression of activated hepatic stellate cell function by genipin, an absorbed form of its component.</description><identifier>ISSN: 0168-8278</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/j.jhep.2004.06.033</identifier><identifier>PMID: 15464238</identifier><identifier>CODEN: JOHEEC</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Carbon Tetrachloride ; Cells, Cultured ; Cholagogues and Choleretics - pharmacology ; Drugs, Chinese Herbal - pharmacology ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatic stellate cells ; Inchin-ko-to ; Iridoid Glycosides ; Iridoids - pharmacology ; Liver - drug effects ; Liver - pathology ; Liver Cirrhosis, Experimental - etiology ; Liver Cirrhosis, Experimental - pathology ; Liver Cirrhosis, Experimental - physiopathology ; Liver fibrosis ; Medical sciences ; Necrosis ; Pyrans - pharmacology ; Rats ; Rats, Inbred F344 ; Survival Analysis ; Swine - blood ; TJ-135</subject><ispartof>Journal of hepatology, 2004-10, Vol.41 (4), p.584-591</ispartof><rights>2004 European Association for the Study of the Liver</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-7197a04e4e879ba569a609c9733cf3bd6e2349643fbbcba38ed77bf6a594d2133</citedby><cites>FETCH-LOGICAL-c382t-7197a04e4e879ba569a609c9733cf3bd6e2349643fbbcba38ed77bf6a594d2133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168827804003125$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16195819$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15464238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inao, Mie</creatorcontrib><creatorcontrib>Mochida, Satoshi</creatorcontrib><creatorcontrib>Matsui, Atsushi</creatorcontrib><creatorcontrib>Eguchi, Yuichiro</creatorcontrib><creatorcontrib>Yulutuz, Yusufu</creatorcontrib><creatorcontrib>Wang, Yanhong</creatorcontrib><creatorcontrib>Naiki, Kayoko</creatorcontrib><creatorcontrib>Kakinuma, Tohru</creatorcontrib><creatorcontrib>Fujimori, Kenji</creatorcontrib><creatorcontrib>Nagoshi, Sumiko</creatorcontrib><creatorcontrib>Fujiwara, Kenji</creatorcontrib><title>Japanese herbal medicine Inchin-ko-to as a therapeutic drug for liver fibrosis</title><title>Journal of hepatology</title><addtitle>J Hepatol</addtitle><description>Inchin-ko-to (TJ-135) is an herbal medicine used in Japan for treatment of icteric patients with cirrhosis. Its efficacy as an anti-fibrogenic drug was evaluated in relation to stellate cell activation.
Liver fibrosis was induced in rats by repeated injections of carbon tetrachloride (CCl
4) or pig-serum. Oral administration of TJ-135 improved the mortality of rats given CCl
4 with reduced extents of liver necrosis and fibrosis. Similar improvement of liver fibrosis was found in rats given pig-serum showing no liver necrosis.
DNA synthesis of stellate cells activated in vitro after isolation from normal rat liver was decreased by culture with TJ-135 in a dose-related manner, accompanied by decreased smooth muscle α actin expression and contractility. Such attenuation was not found in the cells cultured with geniposide, an iridoid compound of TJ-135, but genipin, an aglycone of geniposide formed in the gut by action of bacterial flora, markedly decreased stellate cell activation without affecting synthesis of proteins other than collagen.
TJ-135 may be useful for treatment of liver fibrosis and portal hypertension through suppression of activated hepatic stellate cell function by genipin, an absorbed form of its component.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carbon Tetrachloride</subject><subject>Cells, Cultured</subject><subject>Cholagogues and Choleretics - pharmacology</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatic stellate cells</subject><subject>Inchin-ko-to</subject><subject>Iridoid Glycosides</subject><subject>Iridoids - pharmacology</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Liver Cirrhosis, Experimental - etiology</subject><subject>Liver Cirrhosis, Experimental - pathology</subject><subject>Liver Cirrhosis, Experimental - physiopathology</subject><subject>Liver fibrosis</subject><subject>Medical sciences</subject><subject>Necrosis</subject><subject>Pyrans - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Survival Analysis</subject><subject>Swine - blood</subject><subject>TJ-135</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90D1PwzAQgGELgaB8_AEG5AW2hHPsOrHEghCfQrDAbNnOhbqkSbATJP49rlqJjcnLc6fzS8gpg5wBk5fLfLnAIS8ARA4yB853yIxJgAykYLtkllCVVUVZHZDDGJcAwEGJfXLA5kKKglcz8vJkBtNhRLrAYE1LV1h75zukj51b-C777LOxpyZSQ8dEzIDT6B2tw_RBmz7Q1n9joI23oY8-HpO9xrQRT7bvEXm_u327ecieX-8fb66fM8erYsxKpkoDAgVWpbJmLpWRoJwqOXcNt7XEggslBW-sddbwCuuytI00cyXqgnF-RC42e4fQf00YR73y0WHbpr_0U9RSKiGYYgkWG-jSfTFgo4fgVyb8aAZ6XVEv9bqiXlfUIHWqmIbOttsnm3r8jWyzJXC-BSY60zbBdM7HPyeZmldMJXe1cZhafHsMOjqPnUuNA7pR173_745fPUGP3g</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>Inao, Mie</creator><creator>Mochida, Satoshi</creator><creator>Matsui, Atsushi</creator><creator>Eguchi, Yuichiro</creator><creator>Yulutuz, Yusufu</creator><creator>Wang, Yanhong</creator><creator>Naiki, Kayoko</creator><creator>Kakinuma, Tohru</creator><creator>Fujimori, Kenji</creator><creator>Nagoshi, Sumiko</creator><creator>Fujiwara, Kenji</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041001</creationdate><title>Japanese herbal medicine Inchin-ko-to as a therapeutic drug for liver fibrosis</title><author>Inao, Mie ; Mochida, Satoshi ; Matsui, Atsushi ; Eguchi, Yuichiro ; Yulutuz, Yusufu ; Wang, Yanhong ; Naiki, Kayoko ; Kakinuma, Tohru ; Fujimori, Kenji ; Nagoshi, Sumiko ; Fujiwara, Kenji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-7197a04e4e879ba569a609c9733cf3bd6e2349643fbbcba38ed77bf6a594d2133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carbon Tetrachloride</topic><topic>Cells, Cultured</topic><topic>Cholagogues and Choleretics - pharmacology</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatic stellate cells</topic><topic>Inchin-ko-to</topic><topic>Iridoid Glycosides</topic><topic>Iridoids - pharmacology</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>Liver Cirrhosis, Experimental - etiology</topic><topic>Liver Cirrhosis, Experimental - pathology</topic><topic>Liver Cirrhosis, Experimental - physiopathology</topic><topic>Liver fibrosis</topic><topic>Medical sciences</topic><topic>Necrosis</topic><topic>Pyrans - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Survival Analysis</topic><topic>Swine - blood</topic><topic>TJ-135</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inao, Mie</creatorcontrib><creatorcontrib>Mochida, Satoshi</creatorcontrib><creatorcontrib>Matsui, Atsushi</creatorcontrib><creatorcontrib>Eguchi, Yuichiro</creatorcontrib><creatorcontrib>Yulutuz, Yusufu</creatorcontrib><creatorcontrib>Wang, Yanhong</creatorcontrib><creatorcontrib>Naiki, Kayoko</creatorcontrib><creatorcontrib>Kakinuma, Tohru</creatorcontrib><creatorcontrib>Fujimori, Kenji</creatorcontrib><creatorcontrib>Nagoshi, Sumiko</creatorcontrib><creatorcontrib>Fujiwara, Kenji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inao, Mie</au><au>Mochida, Satoshi</au><au>Matsui, Atsushi</au><au>Eguchi, Yuichiro</au><au>Yulutuz, Yusufu</au><au>Wang, Yanhong</au><au>Naiki, Kayoko</au><au>Kakinuma, Tohru</au><au>Fujimori, Kenji</au><au>Nagoshi, Sumiko</au><au>Fujiwara, Kenji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Japanese herbal medicine Inchin-ko-to as a therapeutic drug for liver fibrosis</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>41</volume><issue>4</issue><spage>584</spage><epage>591</epage><pages>584-591</pages><issn>0168-8278</issn><eissn>1600-0641</eissn><coden>JOHEEC</coden><abstract>Inchin-ko-to (TJ-135) is an herbal medicine used in Japan for treatment of icteric patients with cirrhosis. Its efficacy as an anti-fibrogenic drug was evaluated in relation to stellate cell activation.
Liver fibrosis was induced in rats by repeated injections of carbon tetrachloride (CCl
4) or pig-serum. Oral administration of TJ-135 improved the mortality of rats given CCl
4 with reduced extents of liver necrosis and fibrosis. Similar improvement of liver fibrosis was found in rats given pig-serum showing no liver necrosis.
DNA synthesis of stellate cells activated in vitro after isolation from normal rat liver was decreased by culture with TJ-135 in a dose-related manner, accompanied by decreased smooth muscle α actin expression and contractility. Such attenuation was not found in the cells cultured with geniposide, an iridoid compound of TJ-135, but genipin, an aglycone of geniposide formed in the gut by action of bacterial flora, markedly decreased stellate cell activation without affecting synthesis of proteins other than collagen.
TJ-135 may be useful for treatment of liver fibrosis and portal hypertension through suppression of activated hepatic stellate cell function by genipin, an absorbed form of its component.</abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>15464238</pmid><doi>10.1016/j.jhep.2004.06.033</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0168-8278 |
| ispartof | Journal of hepatology, 2004-10, Vol.41 (4), p.584-591 |
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| subjects | Animals Biological and medical sciences Carbon Tetrachloride Cells, Cultured Cholagogues and Choleretics - pharmacology Drugs, Chinese Herbal - pharmacology Gastroenterology. Liver. Pancreas. Abdomen Hepatic stellate cells Inchin-ko-to Iridoid Glycosides Iridoids - pharmacology Liver - drug effects Liver - pathology Liver Cirrhosis, Experimental - etiology Liver Cirrhosis, Experimental - pathology Liver Cirrhosis, Experimental - physiopathology Liver fibrosis Medical sciences Necrosis Pyrans - pharmacology Rats Rats, Inbred F344 Survival Analysis Swine - blood TJ-135 |
| title | Japanese herbal medicine Inchin-ko-to as a therapeutic drug for liver fibrosis |
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