Pharmacologic management of chronic rhinosinusitis, alone or with nasal polyposis
Patients with chronic rhinosinusitis (CRS) and chronic rhinosinusitis with nasal polyposis (CRSwNP) commonly present with nasal obstruction, nasal discharge, facial pressure/pain, and hyposmia of prolonged duration. Recent evidence suggests that, despite clinical similarities, CRS and CRSwNP are dis...
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| Veröffentlicht in: | Current allergy and asthma reports 2004-11, Vol.4 (6), p.478-485 |
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| creator | Gillespie, M Boyd Osguthorpe, J David |
| description | Patients with chronic rhinosinusitis (CRS) and chronic rhinosinusitis with nasal polyposis (CRSwNP) commonly present with nasal obstruction, nasal discharge, facial pressure/pain, and hyposmia of prolonged duration. Recent evidence suggests that, despite clinical similarities, CRS and CRSwNP are distinct entities with separate inflammatory pathways and cytokine profiles. Antibiotics and nasal steroids are the mainstay of treatment in CRS, whereas combination systemic and nasal steroids are the foundation of CRSwNP management. Allergy therapy may play a significant role in CRS, whereas antileukotriene therapy has demonstrated promise in CRSwNP. Although prolonged medical therapy is usually necessary with both disorders, surgery may also be required to relieve refractory symptoms, and to improve sinus aeration and nasal access for topical therapy. |
| doi_str_mv | 10.1007/s11882-004-0015-3 |
| format | Article |
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Recent evidence suggests that, despite clinical similarities, CRS and CRSwNP are distinct entities with separate inflammatory pathways and cytokine profiles. Antibiotics and nasal steroids are the mainstay of treatment in CRS, whereas combination systemic and nasal steroids are the foundation of CRSwNP management. Allergy therapy may play a significant role in CRS, whereas antileukotriene therapy has demonstrated promise in CRSwNP. 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Recent evidence suggests that, despite clinical similarities, CRS and CRSwNP are distinct entities with separate inflammatory pathways and cytokine profiles. Antibiotics and nasal steroids are the mainstay of treatment in CRS, whereas combination systemic and nasal steroids are the foundation of CRSwNP management. Allergy therapy may play a significant role in CRS, whereas antileukotriene therapy has demonstrated promise in CRSwNP. Although prolonged medical therapy is usually necessary with both disorders, surgery may also be required to relieve refractory symptoms, and to improve sinus aeration and nasal access for topical therapy.</description><subject>Administration, Topical</subject><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Allergies</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Chronic Disease</subject><subject>Comorbidity</subject><subject>Drug Therapy, Combination</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Leukotriene Antagonists - therapeutic use</subject><subject>Nasal Obstruction</subject><subject>Nasal Polyps - complications</subject><subject>Nasal Polyps - drug therapy</subject><subject>Nose</subject><subject>Rhinitis - complications</subject><subject>Rhinitis - drug therapy</subject><subject>Rhinitis - pathology</subject><subject>Sinusitis - complications</subject><subject>Sinusitis - drug therapy</subject><subject>Sinusitis - pathology</subject><issn>1529-7322</issn><issn>1534-6315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkE1LxDAQhoMorq7-AC9SPHiymq8m7VEWv2BBBT2HNEm3WdqkJi2y_96suyB4CBOG5x1mHgAuELxFEPK7iFBZ4hxCmh4qcnIATlBBaM4IKg63f1zlnGA8A6cxriHEKYWPwQwVlGGOihPw_tbK0EvlO7-yKuulkyvTGzdmvslUG7xL3dBa56N1U7SjjTeZ7LwzmQ_Ztx3bzMkou2zw3WZIUDwDR43sojnf1zn4fHz4WDzny9enl8X9MlcE0zEvYUk1gxLWmild1oqjpoaSppNUVaRNK0IMV7ViStKK8apWSGkNNae6hhSRObjezR2C_5pMHEVvozJdJ53xUxSMVZRUuEzg1T9w7afg0m6i5BVjGP1CaAep4GMMphFDsL0MG4Gg2MoWO9kiyRZb2YKkzOV-8FT3Rv8l9nbJD9CoepQ</recordid><startdate>20041101</startdate><enddate>20041101</enddate><creator>Gillespie, M Boyd</creator><creator>Osguthorpe, J David</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20041101</creationdate><title>Pharmacologic management of chronic rhinosinusitis, alone or with nasal polyposis</title><author>Gillespie, M Boyd ; Osguthorpe, J David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c324t-8084d60a0bd6cd8bc71fb0a4118c95020933e7cbc6ca49679bc1cdd0d74db0413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Administration, Topical</topic><topic>Adrenal Cortex Hormones - therapeutic use</topic><topic>Allergies</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Chronic Disease</topic><topic>Comorbidity</topic><topic>Drug Therapy, Combination</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Leukotriene Antagonists - therapeutic use</topic><topic>Nasal Obstruction</topic><topic>Nasal Polyps - complications</topic><topic>Nasal Polyps - drug therapy</topic><topic>Nose</topic><topic>Rhinitis - complications</topic><topic>Rhinitis - drug therapy</topic><topic>Rhinitis - pathology</topic><topic>Sinusitis - complications</topic><topic>Sinusitis - drug therapy</topic><topic>Sinusitis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gillespie, M Boyd</creatorcontrib><creatorcontrib>Osguthorpe, J David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Current allergy and asthma reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gillespie, M Boyd</au><au>Osguthorpe, J David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacologic management of chronic rhinosinusitis, alone or with nasal polyposis</atitle><jtitle>Current allergy and asthma reports</jtitle><addtitle>Curr Allergy Asthma Rep</addtitle><date>2004-11-01</date><risdate>2004</risdate><volume>4</volume><issue>6</issue><spage>478</spage><epage>485</epage><pages>478-485</pages><issn>1529-7322</issn><eissn>1534-6315</eissn><abstract>Patients with chronic rhinosinusitis (CRS) and chronic rhinosinusitis with nasal polyposis (CRSwNP) commonly present with nasal obstruction, nasal discharge, facial pressure/pain, and hyposmia of prolonged duration. 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| subjects | Administration, Topical Adrenal Cortex Hormones - therapeutic use Allergies Anti-Bacterial Agents - therapeutic use Chronic Disease Comorbidity Drug Therapy, Combination Humans Inflammation Leukotriene Antagonists - therapeutic use Nasal Obstruction Nasal Polyps - complications Nasal Polyps - drug therapy Nose Rhinitis - complications Rhinitis - drug therapy Rhinitis - pathology Sinusitis - complications Sinusitis - drug therapy Sinusitis - pathology |
| title | Pharmacologic management of chronic rhinosinusitis, alone or with nasal polyposis |
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