Effect of Drug-loading Methods on Drug Load, Encapsulation Efficiency and Release Properties of Alginate/Poly-L-Arginine/Chitosan Ternary Complex Microcapsules
The drug‐loaded alginate/poly‐L‐arginine/chitosan ternary complex microcapsules were prepared by mixing method, absorption method and the combined method of mixing and absorption, respectively. The effect of drug‐loading methods on drug load, the encapsulation efficiency and the release properties o...
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| Veröffentlicht in: | Macromolecular bioscience 2004-01, Vol.4 (1), p.27-30 |
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| creator | Wang, Shi-Bin Chen, Ai-Zheng Weng, Lian-Jin Chen, Mei-Ying Xie, Xiao-Lin |
| description | The drug‐loaded alginate/poly‐L‐arginine/chitosan ternary complex microcapsules were prepared by mixing method, absorption method and the combined method of mixing and absorption, respectively. The effect of drug‐loading methods on drug load, the encapsulation efficiency and the release properties of the complex microcapsules were investigated. The results showed that the absorption process is a dominating factor to greatly increase the drug load of Hb into microcapsules. Upon loading Hb into microcapsules by combined method of mixing and absorption, the drug load (19.9%) is up to the maximum value, and the encapsulation efficiency is 93.8%. Moreover, the drug release is a zero‐order kinetics process for the ternary complex microcapsules made by mixing. For the complex microcapsules made by absorption, the drug release is a first‐order kinetics. However, for the complex microcapsules made by combining the mixing and the absorption, the drug release obeys a first‐order kinetics during the first eighteen hours, changing afterwards to a zero‐order kinetics process.
Effect of drug‐loading methods on drug load and encapsulation efficiency of alginate/poly‐L‐arginine/chitosan ternary complex microcapsules. |
| doi_str_mv | 10.1002/mabi.200300043 |
| format | Article |
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Effect of drug‐loading methods on drug load and encapsulation efficiency of alginate/poly‐L‐arginine/chitosan ternary complex microcapsules.</description><identifier>ISSN: 1616-5187</identifier><identifier>EISSN: 1616-5195</identifier><identifier>DOI: 10.1002/mabi.200300043</identifier><identifier>PMID: 15468284</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Alginates - chemistry ; Animals ; Applied sciences ; Arginine - chemistry ; Capsules - administration & dosage ; Capsules - chemical synthesis ; Capsules - chemistry ; Cattle ; chitosan ; Chitosan - chemistry ; Delayed-Action Preparations - administration & dosage ; Delayed-Action Preparations - chemical synthesis ; Delayed-Action Preparations - chemistry ; Drug Carriers - chemical synthesis ; Drug Carriers - chemistry ; drug delivery systems ; Drug Delivery Systems - methods ; Exact sciences and technology ; Forms of application and semi-finished materials ; Glucuronic Acid - chemistry ; Hemoglobins - chemistry ; Hexuronic Acids - chemistry ; microencapsulation ; Miscellaneous ; poly-L-arginine ; Polymer industry, paints, wood ; proteins ; Technology of polymers</subject><ispartof>Macromolecular bioscience, 2004-01, Vol.4 (1), p.27-30</ispartof><rights>Copyright © 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5063-524f70610daf700086cfb9083708618a65d0563d025f0585dfcdb6ea16be3a6d3</citedby><cites>FETCH-LOGICAL-c5063-524f70610daf700086cfb9083708618a65d0563d025f0585dfcdb6ea16be3a6d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmabi.200300043$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15459428$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15468284$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Shi-Bin</creatorcontrib><creatorcontrib>Chen, Ai-Zheng</creatorcontrib><creatorcontrib>Weng, Lian-Jin</creatorcontrib><creatorcontrib>Chen, Mei-Ying</creatorcontrib><creatorcontrib>Xie, Xiao-Lin</creatorcontrib><title>Effect of Drug-loading Methods on Drug Load, Encapsulation Efficiency and Release Properties of Alginate/Poly-L-Arginine/Chitosan Ternary Complex Microcapsules</title><title>Macromolecular bioscience</title><addtitle>Macromol. Biosci</addtitle><description>The drug‐loaded alginate/poly‐L‐arginine/chitosan ternary complex microcapsules were prepared by mixing method, absorption method and the combined method of mixing and absorption, respectively. The effect of drug‐loading methods on drug load, the encapsulation efficiency and the release properties of the complex microcapsules were investigated. The results showed that the absorption process is a dominating factor to greatly increase the drug load of Hb into microcapsules. Upon loading Hb into microcapsules by combined method of mixing and absorption, the drug load (19.9%) is up to the maximum value, and the encapsulation efficiency is 93.8%. Moreover, the drug release is a zero‐order kinetics process for the ternary complex microcapsules made by mixing. For the complex microcapsules made by absorption, the drug release is a first‐order kinetics. However, for the complex microcapsules made by combining the mixing and the absorption, the drug release obeys a first‐order kinetics during the first eighteen hours, changing afterwards to a zero‐order kinetics process.
Effect of drug‐loading methods on drug load and encapsulation efficiency of alginate/poly‐L‐arginine/chitosan ternary complex microcapsules.</description><subject>Alginates - chemistry</subject><subject>Animals</subject><subject>Applied sciences</subject><subject>Arginine - chemistry</subject><subject>Capsules - administration & dosage</subject><subject>Capsules - chemical synthesis</subject><subject>Capsules - chemistry</subject><subject>Cattle</subject><subject>chitosan</subject><subject>Chitosan - chemistry</subject><subject>Delayed-Action Preparations - administration & dosage</subject><subject>Delayed-Action Preparations - chemical synthesis</subject><subject>Delayed-Action Preparations - chemistry</subject><subject>Drug Carriers - chemical synthesis</subject><subject>Drug Carriers - chemistry</subject><subject>drug delivery systems</subject><subject>Drug Delivery Systems - methods</subject><subject>Exact sciences and technology</subject><subject>Forms of application and semi-finished materials</subject><subject>Glucuronic Acid - chemistry</subject><subject>Hemoglobins - chemistry</subject><subject>Hexuronic Acids - chemistry</subject><subject>microencapsulation</subject><subject>Miscellaneous</subject><subject>poly-L-arginine</subject><subject>Polymer industry, paints, wood</subject><subject>proteins</subject><subject>Technology of polymers</subject><issn>1616-5187</issn><issn>1616-5195</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1z0zAQhjUMDG0DV46MLnDCiWRbsn0MaVoKSelAGY4aRV6nAlkykj00v4a_ioIzobeedrV63v2YF6FXlEwpIemslRs9TQnJCCF59gSdUk55wmjFnh7zsjhBZyH8IIQWZZU-RyeU5bxMy_wU_Vk2Dageuwaf-2GbGCdrbbd4Df2dqwN29l8dr2L9HV5aJbswGNnr-BGlWmmwaoelrfEXMCAD4BvvOvC9hrDvOjdbbWUPsxtndskqmfv41hZmizvduyAtvgVvpd_hhWs7A_d4rZV34xwIL9CzRpoALw9xgr5dLG8XH5LV58urxXyVKEZ4lrA0bwrCKalljISUXDWbipRZEVNaSs5qwnhWk5Q1hJWsblS94SAp30AmeZ1N0Nuxb-fdrwFCL1odFBgjLbghCM6rPGM8fxRM48CqjIZM0HQE4zUheGhE53UbDxWUiL13Yu-dOHoXBa8PnYdNC_V__GBWBN4cABmUNI2XVunwkGNVnpaRq0butzawe2SsWM_fXz1cIhm1OvRwf9RK_1PwIiuY-H59Karr9aev9PyjSLO_9HXDAg</recordid><startdate>20040121</startdate><enddate>20040121</enddate><creator>Wang, Shi-Bin</creator><creator>Chen, Ai-Zheng</creator><creator>Weng, Lian-Jin</creator><creator>Chen, Mei-Ying</creator><creator>Xie, Xiao-Lin</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley-VCH</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20040121</creationdate><title>Effect of Drug-loading Methods on Drug Load, Encapsulation Efficiency and Release Properties of Alginate/Poly-L-Arginine/Chitosan Ternary Complex Microcapsules</title><author>Wang, Shi-Bin ; Chen, Ai-Zheng ; Weng, Lian-Jin ; Chen, Mei-Ying ; Xie, Xiao-Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5063-524f70610daf700086cfb9083708618a65d0563d025f0585dfcdb6ea16be3a6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Alginates - chemistry</topic><topic>Animals</topic><topic>Applied sciences</topic><topic>Arginine - chemistry</topic><topic>Capsules - administration & dosage</topic><topic>Capsules - chemical synthesis</topic><topic>Capsules - chemistry</topic><topic>Cattle</topic><topic>chitosan</topic><topic>Chitosan - chemistry</topic><topic>Delayed-Action Preparations - administration & dosage</topic><topic>Delayed-Action Preparations - chemical synthesis</topic><topic>Delayed-Action Preparations - chemistry</topic><topic>Drug Carriers - chemical synthesis</topic><topic>Drug Carriers - chemistry</topic><topic>drug delivery systems</topic><topic>Drug Delivery Systems - methods</topic><topic>Exact sciences and technology</topic><topic>Forms of application and semi-finished materials</topic><topic>Glucuronic Acid - chemistry</topic><topic>Hemoglobins - chemistry</topic><topic>Hexuronic Acids - chemistry</topic><topic>microencapsulation</topic><topic>Miscellaneous</topic><topic>poly-L-arginine</topic><topic>Polymer industry, paints, wood</topic><topic>proteins</topic><topic>Technology of polymers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Shi-Bin</creatorcontrib><creatorcontrib>Chen, Ai-Zheng</creatorcontrib><creatorcontrib>Weng, Lian-Jin</creatorcontrib><creatorcontrib>Chen, Mei-Ying</creatorcontrib><creatorcontrib>Xie, Xiao-Lin</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Macromolecular bioscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Shi-Bin</au><au>Chen, Ai-Zheng</au><au>Weng, Lian-Jin</au><au>Chen, Mei-Ying</au><au>Xie, Xiao-Lin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Drug-loading Methods on Drug Load, Encapsulation Efficiency and Release Properties of Alginate/Poly-L-Arginine/Chitosan Ternary Complex Microcapsules</atitle><jtitle>Macromolecular bioscience</jtitle><addtitle>Macromol. Biosci</addtitle><date>2004-01-21</date><risdate>2004</risdate><volume>4</volume><issue>1</issue><spage>27</spage><epage>30</epage><pages>27-30</pages><issn>1616-5187</issn><eissn>1616-5195</eissn><abstract>The drug‐loaded alginate/poly‐L‐arginine/chitosan ternary complex microcapsules were prepared by mixing method, absorption method and the combined method of mixing and absorption, respectively. The effect of drug‐loading methods on drug load, the encapsulation efficiency and the release properties of the complex microcapsules were investigated. The results showed that the absorption process is a dominating factor to greatly increase the drug load of Hb into microcapsules. Upon loading Hb into microcapsules by combined method of mixing and absorption, the drug load (19.9%) is up to the maximum value, and the encapsulation efficiency is 93.8%. Moreover, the drug release is a zero‐order kinetics process for the ternary complex microcapsules made by mixing. For the complex microcapsules made by absorption, the drug release is a first‐order kinetics. However, for the complex microcapsules made by combining the mixing and the absorption, the drug release obeys a first‐order kinetics during the first eighteen hours, changing afterwards to a zero‐order kinetics process.
Effect of drug‐loading methods on drug load and encapsulation efficiency of alginate/poly‐L‐arginine/chitosan ternary complex microcapsules.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>15468284</pmid><doi>10.1002/mabi.200300043</doi><tpages>4</tpages></addata></record> |
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| subjects | Alginates - chemistry Animals Applied sciences Arginine - chemistry Capsules - administration & dosage Capsules - chemical synthesis Capsules - chemistry Cattle chitosan Chitosan - chemistry Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - chemical synthesis Delayed-Action Preparations - chemistry Drug Carriers - chemical synthesis Drug Carriers - chemistry drug delivery systems Drug Delivery Systems - methods Exact sciences and technology Forms of application and semi-finished materials Glucuronic Acid - chemistry Hemoglobins - chemistry Hexuronic Acids - chemistry microencapsulation Miscellaneous poly-L-arginine Polymer industry, paints, wood proteins Technology of polymers |
| title | Effect of Drug-loading Methods on Drug Load, Encapsulation Efficiency and Release Properties of Alginate/Poly-L-Arginine/Chitosan Ternary Complex Microcapsules |
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