Changes in neuropsychological functioning with progression of HIV-1 infection: results of an 8-year longitudinal investigation
Despite the advent of more effective treatments for HIV-1 infection, cognitive impairment is still frequent and questions remain regarding which areas of impairment are more common in the different disease stages. This study investigated cognitive performance over an 8-year period of time in 59 HIV-...
Gespeichert in:
| Veröffentlicht in: | AIDS and behavior 2004-09, Vol.8 (3), p.345-355 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 355 |
|---|---|
| container_issue | 3 |
| container_start_page | 345 |
| container_title | AIDS and behavior |
| container_volume | 8 |
| creator | Baldewicz, Teri T Leserman, Jane Silva, Susan G Petitto, John M Golden, Robert N Perkins, Diana O Barroso, Julie Evans, Dwight L |
| description | Despite the advent of more effective treatments for HIV-1 infection, cognitive impairment is still frequent and questions remain regarding which areas of impairment are more common in the different disease stages. This study investigated cognitive performance over an 8-year period of time in 59 HIV-1 seropositive (HIV-1+) men who were clinically asymptomatic at study entry, in comparison to a cohort of 55 HIV-1 seronegative (HIV-1-) men. Every 6 months we examined cognitive functioning in 5 domains-fine motor speed, attention, verbal memory, executive functioning, and speed of information processing. We found that patients with AIDS scored significantly worse on fine motor speed and speed of information processing than HIV-1- individuals and the HIV-1+ non-AIDS patients. In addition, the HIV-1+ non-AIDS patients performed more poorly than the HIV-1- group on speed of information processing. Depressive symptoms were also associated with diminished performance on measures of attention, executive functioning, and speed of information processing. Further research is needed to examine the effects of disease stage and depression on cognitive impairment in the era of new HIV treatments. |
| doi_str_mv | 10.1023/B:AIBE.0000044081.42034.54 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66943355</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66943355</sourcerecordid><originalsourceid>FETCH-LOGICAL-c404t-dd3bcb6d4f75f9154a7abad0322cc08a575c2a310bba297ecca4c8b67bc18fc73</originalsourceid><addsrcrecordid>eNqFkU1PxCAQhonR-P0XDPHgrSsUKGVv7mbVTUy8qFdCKe1iurBCq9mLv12qm5h4cS5MZp53ZsILwCVGE4xycj2b3ixniwkag1JU4gnNEaETRvfAMWacZCRndD_lSKCM44IdgZMYXxMuCi4OwRFmlLOixMfgc75SrjURWgedGYLfxK1e-c63VqsONoPTvfXOuhZ-2H4FN8G3wcSYatA38H75kuGkbcw3NoWpN3R9HHvKwTLbGhVg511r-6G2Lo207t3E3rZqFJyBg0Z10Zzv3lPwfLt4mt9nD493y_nNQ6Ypon1W16TSVVHThrNGpOsVV5WqEclzrVGpGGc6VwSjqlK54EZrRXVZFbzSuGw0J6fg6mduuv9tSPvl2kZtuk4544coi0JQQhj7H8QJKwn5F8ScC1xwlMDLP-CrH0L6iShzjAkigosETX8gHXyMwTRyE-xaha3ESI6my5kcTZe_pstv0yWjSXyx2zBUa1P_Sncuky9_16q0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>211303979</pqid></control><display><type>article</type><title>Changes in neuropsychological functioning with progression of HIV-1 infection: results of an 8-year longitudinal investigation</title><source>MEDLINE</source><source>Sociological Abstracts</source><source>SpringerLink Journals - AutoHoldings</source><creator>Baldewicz, Teri T ; Leserman, Jane ; Silva, Susan G ; Petitto, John M ; Golden, Robert N ; Perkins, Diana O ; Barroso, Julie ; Evans, Dwight L</creator><creatorcontrib>Baldewicz, Teri T ; Leserman, Jane ; Silva, Susan G ; Petitto, John M ; Golden, Robert N ; Perkins, Diana O ; Barroso, Julie ; Evans, Dwight L</creatorcontrib><description>Despite the advent of more effective treatments for HIV-1 infection, cognitive impairment is still frequent and questions remain regarding which areas of impairment are more common in the different disease stages. This study investigated cognitive performance over an 8-year period of time in 59 HIV-1 seropositive (HIV-1+) men who were clinically asymptomatic at study entry, in comparison to a cohort of 55 HIV-1 seronegative (HIV-1-) men. Every 6 months we examined cognitive functioning in 5 domains-fine motor speed, attention, verbal memory, executive functioning, and speed of information processing. We found that patients with AIDS scored significantly worse on fine motor speed and speed of information processing than HIV-1- individuals and the HIV-1+ non-AIDS patients. In addition, the HIV-1+ non-AIDS patients performed more poorly than the HIV-1- group on speed of information processing. Depressive symptoms were also associated with diminished performance on measures of attention, executive functioning, and speed of information processing. Further research is needed to examine the effects of disease stage and depression on cognitive impairment in the era of new HIV treatments.</description><identifier>ISSN: 1090-7165</identifier><identifier>EISSN: 1573-3254</identifier><identifier>DOI: 10.1023/B:AIBE.0000044081.42034.54</identifier><identifier>PMID: 15475681</identifier><identifier>CODEN: AIBEFC</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Acquired immune deficiency syndrome ; Acquired Immunodeficiency Syndrome - diagnosis ; Acquired Immunodeficiency Syndrome - psychology ; Adult ; AIDS ; AIDS Dementia Complex - diagnosis ; AIDS Dementia Complex - psychology ; Asymptomatic ; Cognitive ability ; Comorbidity ; Dementia ; Depression - diagnosis ; Depression - psychology ; Disease Progression ; Executive function ; HIV ; HIV Seropositivity - diagnosis ; HIV Seropositivity - psychology ; HIV-1 ; Homosexuality, Male - psychology ; Homosexuality, Male - statistics & numerical data ; Human immunodeficiency virus ; Human immunodeficiency virus 1 ; Humans ; Indexing in process ; Infections ; Information processing ; Investigations ; Longitudinal Studies ; Male ; Medicine ; Memory ; Mental depression ; Middle Aged ; Neuropsychological Tests - statistics & numerical data ; Neuropsychology ; Neurosciences ; Psychiatry ; Psychometrics - statistics & numerical data ; Reaction Time</subject><ispartof>AIDS and behavior, 2004-09, Vol.8 (3), p.345-355</ispartof><rights>Copyright (c) 2004 Springer Science+Business Media, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-dd3bcb6d4f75f9154a7abad0322cc08a575c2a310bba297ecca4c8b67bc18fc73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27323,27903,27904,33753,33754</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15475681$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baldewicz, Teri T</creatorcontrib><creatorcontrib>Leserman, Jane</creatorcontrib><creatorcontrib>Silva, Susan G</creatorcontrib><creatorcontrib>Petitto, John M</creatorcontrib><creatorcontrib>Golden, Robert N</creatorcontrib><creatorcontrib>Perkins, Diana O</creatorcontrib><creatorcontrib>Barroso, Julie</creatorcontrib><creatorcontrib>Evans, Dwight L</creatorcontrib><title>Changes in neuropsychological functioning with progression of HIV-1 infection: results of an 8-year longitudinal investigation</title><title>AIDS and behavior</title><addtitle>AIDS Behav</addtitle><description>Despite the advent of more effective treatments for HIV-1 infection, cognitive impairment is still frequent and questions remain regarding which areas of impairment are more common in the different disease stages. This study investigated cognitive performance over an 8-year period of time in 59 HIV-1 seropositive (HIV-1+) men who were clinically asymptomatic at study entry, in comparison to a cohort of 55 HIV-1 seronegative (HIV-1-) men. Every 6 months we examined cognitive functioning in 5 domains-fine motor speed, attention, verbal memory, executive functioning, and speed of information processing. We found that patients with AIDS scored significantly worse on fine motor speed and speed of information processing than HIV-1- individuals and the HIV-1+ non-AIDS patients. In addition, the HIV-1+ non-AIDS patients performed more poorly than the HIV-1- group on speed of information processing. Depressive symptoms were also associated with diminished performance on measures of attention, executive functioning, and speed of information processing. Further research is needed to examine the effects of disease stage and depression on cognitive impairment in the era of new HIV treatments.</description><subject>Acquired immune deficiency syndrome</subject><subject>Acquired Immunodeficiency Syndrome - diagnosis</subject><subject>Acquired Immunodeficiency Syndrome - psychology</subject><subject>Adult</subject><subject>AIDS</subject><subject>AIDS Dementia Complex - diagnosis</subject><subject>AIDS Dementia Complex - psychology</subject><subject>Asymptomatic</subject><subject>Cognitive ability</subject><subject>Comorbidity</subject><subject>Dementia</subject><subject>Depression - diagnosis</subject><subject>Depression - psychology</subject><subject>Disease Progression</subject><subject>Executive function</subject><subject>HIV</subject><subject>HIV Seropositivity - diagnosis</subject><subject>HIV Seropositivity - psychology</subject><subject>HIV-1</subject><subject>Homosexuality, Male - psychology</subject><subject>Homosexuality, Male - statistics & numerical data</subject><subject>Human immunodeficiency virus</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Indexing in process</subject><subject>Infections</subject><subject>Information processing</subject><subject>Investigations</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medicine</subject><subject>Memory</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests - statistics & numerical data</subject><subject>Neuropsychology</subject><subject>Neurosciences</subject><subject>Psychiatry</subject><subject>Psychometrics - statistics & numerical data</subject><subject>Reaction Time</subject><issn>1090-7165</issn><issn>1573-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>BHHNA</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU1PxCAQhonR-P0XDPHgrSsUKGVv7mbVTUy8qFdCKe1iurBCq9mLv12qm5h4cS5MZp53ZsILwCVGE4xycj2b3ixniwkag1JU4gnNEaETRvfAMWacZCRndD_lSKCM44IdgZMYXxMuCi4OwRFmlLOixMfgc75SrjURWgedGYLfxK1e-c63VqsONoPTvfXOuhZ-2H4FN8G3wcSYatA38H75kuGkbcw3NoWpN3R9HHvKwTLbGhVg511r-6G2Lo207t3E3rZqFJyBg0Z10Zzv3lPwfLt4mt9nD493y_nNQ6Ypon1W16TSVVHThrNGpOsVV5WqEclzrVGpGGc6VwSjqlK54EZrRXVZFbzSuGw0J6fg6mduuv9tSPvl2kZtuk4544coi0JQQhj7H8QJKwn5F8ScC1xwlMDLP-CrH0L6iShzjAkigosETX8gHXyMwTRyE-xaha3ESI6my5kcTZe_pstv0yWjSXyx2zBUa1P_Sncuky9_16q0</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Baldewicz, Teri T</creator><creator>Leserman, Jane</creator><creator>Silva, Susan G</creator><creator>Petitto, John M</creator><creator>Golden, Robert N</creator><creator>Perkins, Diana O</creator><creator>Barroso, Julie</creator><creator>Evans, Dwight L</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7T2</scope><scope>7U3</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AM</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGRYB</scope><scope>BHHNA</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HEHIP</scope><scope>K7.</scope><scope>K9.</scope><scope>KB0</scope><scope>M0O</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>Changes in neuropsychological functioning with progression of HIV-1 infection: results of an 8-year longitudinal investigation</title><author>Baldewicz, Teri T ; Leserman, Jane ; Silva, Susan G ; Petitto, John M ; Golden, Robert N ; Perkins, Diana O ; Barroso, Julie ; Evans, Dwight L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-dd3bcb6d4f75f9154a7abad0322cc08a575c2a310bba297ecca4c8b67bc18fc73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Acquired Immunodeficiency Syndrome - diagnosis</topic><topic>Acquired Immunodeficiency Syndrome - psychology</topic><topic>Adult</topic><topic>AIDS</topic><topic>AIDS Dementia Complex - diagnosis</topic><topic>AIDS Dementia Complex - psychology</topic><topic>Asymptomatic</topic><topic>Cognitive ability</topic><topic>Comorbidity</topic><topic>Dementia</topic><topic>Depression - diagnosis</topic><topic>Depression - psychology</topic><topic>Disease Progression</topic><topic>Executive function</topic><topic>HIV</topic><topic>HIV Seropositivity - diagnosis</topic><topic>HIV Seropositivity - psychology</topic><topic>HIV-1</topic><topic>Homosexuality, Male - psychology</topic><topic>Homosexuality, Male - statistics & numerical data</topic><topic>Human immunodeficiency virus</topic><topic>Human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Indexing in process</topic><topic>Infections</topic><topic>Information processing</topic><topic>Investigations</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medicine</topic><topic>Memory</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests - statistics & numerical data</topic><topic>Neuropsychology</topic><topic>Neurosciences</topic><topic>Psychiatry</topic><topic>Psychometrics - statistics & numerical data</topic><topic>Reaction Time</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baldewicz, Teri T</creatorcontrib><creatorcontrib>Leserman, Jane</creatorcontrib><creatorcontrib>Silva, Susan G</creatorcontrib><creatorcontrib>Petitto, John M</creatorcontrib><creatorcontrib>Golden, Robert N</creatorcontrib><creatorcontrib>Perkins, Diana O</creatorcontrib><creatorcontrib>Barroso, Julie</creatorcontrib><creatorcontrib>Evans, Dwight L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Social Services Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Criminal Justice Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Criminology Collection</collection><collection>Sociological Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Sociology Collection</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Criminal Justice</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Sociology Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baldewicz, Teri T</au><au>Leserman, Jane</au><au>Silva, Susan G</au><au>Petitto, John M</au><au>Golden, Robert N</au><au>Perkins, Diana O</au><au>Barroso, Julie</au><au>Evans, Dwight L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in neuropsychological functioning with progression of HIV-1 infection: results of an 8-year longitudinal investigation</atitle><jtitle>AIDS and behavior</jtitle><addtitle>AIDS Behav</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>8</volume><issue>3</issue><spage>345</spage><epage>355</epage><pages>345-355</pages><issn>1090-7165</issn><eissn>1573-3254</eissn><coden>AIBEFC</coden><abstract>Despite the advent of more effective treatments for HIV-1 infection, cognitive impairment is still frequent and questions remain regarding which areas of impairment are more common in the different disease stages. This study investigated cognitive performance over an 8-year period of time in 59 HIV-1 seropositive (HIV-1+) men who were clinically asymptomatic at study entry, in comparison to a cohort of 55 HIV-1 seronegative (HIV-1-) men. Every 6 months we examined cognitive functioning in 5 domains-fine motor speed, attention, verbal memory, executive functioning, and speed of information processing. We found that patients with AIDS scored significantly worse on fine motor speed and speed of information processing than HIV-1- individuals and the HIV-1+ non-AIDS patients. In addition, the HIV-1+ non-AIDS patients performed more poorly than the HIV-1- group on speed of information processing. Depressive symptoms were also associated with diminished performance on measures of attention, executive functioning, and speed of information processing. Further research is needed to examine the effects of disease stage and depression on cognitive impairment in the era of new HIV treatments.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>15475681</pmid><doi>10.1023/B:AIBE.0000044081.42034.54</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1090-7165 |
| ispartof | AIDS and behavior, 2004-09, Vol.8 (3), p.345-355 |
| issn | 1090-7165 1573-3254 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66943355 |
| source | MEDLINE; Sociological Abstracts; SpringerLink Journals - AutoHoldings |
| subjects | Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - diagnosis Acquired Immunodeficiency Syndrome - psychology Adult AIDS AIDS Dementia Complex - diagnosis AIDS Dementia Complex - psychology Asymptomatic Cognitive ability Comorbidity Dementia Depression - diagnosis Depression - psychology Disease Progression Executive function HIV HIV Seropositivity - diagnosis HIV Seropositivity - psychology HIV-1 Homosexuality, Male - psychology Homosexuality, Male - statistics & numerical data Human immunodeficiency virus Human immunodeficiency virus 1 Humans Indexing in process Infections Information processing Investigations Longitudinal Studies Male Medicine Memory Mental depression Middle Aged Neuropsychological Tests - statistics & numerical data Neuropsychology Neurosciences Psychiatry Psychometrics - statistics & numerical data Reaction Time |
| title | Changes in neuropsychological functioning with progression of HIV-1 infection: results of an 8-year longitudinal investigation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T10%3A42%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Changes%20in%20neuropsychological%20functioning%20with%20progression%20of%20HIV-1%20infection:%20results%20of%20an%208-year%20longitudinal%20investigation&rft.jtitle=AIDS%20and%20behavior&rft.au=Baldewicz,%20Teri%20T&rft.date=2004-09-01&rft.volume=8&rft.issue=3&rft.spage=345&rft.epage=355&rft.pages=345-355&rft.issn=1090-7165&rft.eissn=1573-3254&rft.coden=AIBEFC&rft_id=info:doi/10.1023/B:AIBE.0000044081.42034.54&rft_dat=%3Cproquest_cross%3E66943355%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=211303979&rft_id=info:pmid/15475681&rfr_iscdi=true |