Postextinction Infusion of a Mitogen-Activated Protein Kinase Inhibitor into the Medial Prefrontal Cortex Impairs Memory of the Extinction of Conditioned Fear

We investigated whether postextinction training infusion of PD098059, a selective inhibitor of mitogen-activated protein kinase (MAPK) activation, into the medial prefrontal cortex, would impair retention of extinction learning in rats. We found that immediate, but not late (2 or 4 h), postextinctio...

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Veröffentlicht in:	Learning & memory (Cold Spring Harbor, N.Y.) N.Y.), 2004-09, Vol.11 (5), p.540-543
Hauptverfasser:	Hugues, Sandrine, Deschaux, Olivier, Garcia, Rene
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Brain Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors Conditioning Conditioning, Classical - drug effects Drug Administration Schedule Drug Use Enzyme Inhibitors - administration & dosage Extinction, Psychological - drug effects Fear Fear - drug effects Flavonoids - administration & dosage Learning Processes Male Memory Memory - drug effects Mental Recall - drug effects Microinjections Mitogen-Activated Protein Kinases - antagonists & inhibitors Prefrontal Cortex - drug effects Prefrontal Cortex - enzymology Rats Rats, Wistar Responses Retention (Psychology) Time Factors
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