Glutathione depletion up‐regulates Bcl‐2 in BSO‐resistant cells

ABSTRACT Glutathione depletion by inhibition of its synthesis with buthionine sulfoximine (BSO) is a focus of the current research in antitumor therapy, BSO being used as chemosensitizer. We had previously shown that two human tumor cell lines (U937 and HepG2) survive to treatment with BSO: BSO can...

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Veröffentlicht in:	The FASEB journal 2004-10, Vol.18 (13), p.1609-1611
Hauptverfasser:	D’Alessio, Maria, Cerella, Claudia, Amici, Carla, Pesce, Caterina, Coppola, Simona, Fanelli, Claudia, Nicola, Milena, Cristofanon, Silvia, Clavarino, Giovanna, Bergamaschi, Antonio, Magrini, Andrea, Gualandi, Giampiero, Ghibelli, Lina
Format:	Artikel
Sprache:	eng
Schlagworte:	apoptosis Apoptosis - drug effects Buthionine Sulfoximine - pharmacology Cell Line, Tumor Cell Survival - drug effects chemosensitization Drug Resistance, Neoplasm Glutathione - deficiency Glutathione - metabolism Humans NF‐κB oxidative stress Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism U937 Cells Up-Regulation - drug effects
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