Antitumor effect of avermectins
The effect of a mixture of naturally occurring aversectin C and avermectin B 1 on the growth of ascites and solid experimental tumors of mice was studied. It was shown for the first time that avermectins possess a pronounced antitumor action. When added at nontoxic doses, they significantly suppress...
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| Veröffentlicht in: | European journal of pharmacology 2004-10, Vol.501 (1), p.19-23 |
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| container_title | European journal of pharmacology |
| container_volume | 501 |
| creator | Drinyaev, Victor A. Mosin, Vladimir A. Kruglyak, Elena B. Novik, Tamara S. Sterlina, Tatiana S. Ermakova, Natalia V. Kublik, Ludmila N. Levitman, Maria Kh Shaposhnikova, Vera V. Korystov, Yuri N. |
| description | The effect of a mixture of naturally occurring aversectin C and avermectin B
1 on the growth of ascites and solid experimental tumors of mice was studied. It was shown for the first time that avermectins possess a pronounced antitumor action. When added at nontoxic doses, they significantly suppressed the growth of ascites Ehrlich carcinoma and P388 lympholeukemia and solid Ehrlich and 755 carcinomata. With some administration regimens, avermectins suppressed the tumor growth by 70–80%. Avermectins were most effective when injected intraperitoneally. It was also shown that avermectins enhanced the vincristine-induced suppression of the growth of Ehrlich carcinoma, melanoma B16, and P388 lympholeukemia. Avermectins produced this effect only when injected after vincristine. |
| doi_str_mv | 10.1016/j.ejphar.2004.08.009 |
| format | Article |
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1 on the growth of ascites and solid experimental tumors of mice was studied. It was shown for the first time that avermectins possess a pronounced antitumor action. When added at nontoxic doses, they significantly suppressed the growth of ascites Ehrlich carcinoma and P388 lympholeukemia and solid Ehrlich and 755 carcinomata. With some administration regimens, avermectins suppressed the tumor growth by 70–80%. Avermectins were most effective when injected intraperitoneally. It was also shown that avermectins enhanced the vincristine-induced suppression of the growth of Ehrlich carcinoma, melanoma B16, and P388 lympholeukemia. Avermectins produced this effect only when injected after vincristine.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Avermectin</subject><subject>Carcinoma, Ehrlich Tumor - drug therapy</subject><subject>Cell Proliferation - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ivermectin - analogs & derivatives</subject><subject>Ivermectin - pharmacology</subject><subject>Ivermectin - therapeutic use</subject><subject>Leukemia P388 - drug therapy</subject><subject>Male</subject><subject>Melanoma, Experimental - drug therapy</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred DBA</subject><subject>Mouse</subject><subject>Tumor growth</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQhhdRbK3-A9GevCXObrNfF0GKX1Dwoudlk8zihiapu0nBf--WFLx5mjk87zvMQ8g1hZwCFfdNjs3uy4acARQ5qBxAn5A5VVJnICk7JXMAWmRMaz0jFzE2AMA14-dkRnkhCuBqTm4fu8EPY9uHJTqH1bDs3dLuMbRp9128JGfObiNeHeeCfD4_faxfs837y9v6cZNVK66GbCWpFoCUsrSwUnDqtBOstIKilbUq61pz7lDQgqtSYuWkhZI5JUp0WsrVgtxNvbvQf48YB9P6WOF2azvsx2iE0AXVwBNYTGAV-hgDOrMLvrXhx1AwBzGmMZMYcxBjQJkkJsVujv1j2WL9FzqaSMDDBGD6cu8xmFh57CqsfUgqTN37_y_8AjetdMk</recordid><startdate>20041006</startdate><enddate>20041006</enddate><creator>Drinyaev, Victor A.</creator><creator>Mosin, Vladimir A.</creator><creator>Kruglyak, Elena B.</creator><creator>Novik, Tamara S.</creator><creator>Sterlina, Tatiana S.</creator><creator>Ermakova, Natalia V.</creator><creator>Kublik, Ludmila N.</creator><creator>Levitman, Maria Kh</creator><creator>Shaposhnikova, Vera V.</creator><creator>Korystov, Yuri N.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041006</creationdate><title>Antitumor effect of avermectins</title><author>Drinyaev, Victor A. ; Mosin, Vladimir A. ; Kruglyak, Elena B. ; Novik, Tamara S. ; Sterlina, Tatiana S. ; Ermakova, Natalia V. ; Kublik, Ludmila N. ; Levitman, Maria Kh ; Shaposhnikova, Vera V. ; Korystov, Yuri N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-371960e1127192b651f9f62ba61ea7d8bdd955fe61458b7ecf7a0b2f86bef9773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Avermectin</topic><topic>Carcinoma, Ehrlich Tumor - drug therapy</topic><topic>Cell Proliferation - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ivermectin - analogs & derivatives</topic><topic>Ivermectin - pharmacology</topic><topic>Ivermectin - therapeutic use</topic><topic>Leukemia P388 - drug therapy</topic><topic>Male</topic><topic>Melanoma, Experimental - drug therapy</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred DBA</topic><topic>Mouse</topic><topic>Tumor growth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Drinyaev, Victor A.</creatorcontrib><creatorcontrib>Mosin, Vladimir A.</creatorcontrib><creatorcontrib>Kruglyak, Elena B.</creatorcontrib><creatorcontrib>Novik, Tamara S.</creatorcontrib><creatorcontrib>Sterlina, Tatiana S.</creatorcontrib><creatorcontrib>Ermakova, Natalia V.</creatorcontrib><creatorcontrib>Kublik, Ludmila N.</creatorcontrib><creatorcontrib>Levitman, Maria Kh</creatorcontrib><creatorcontrib>Shaposhnikova, Vera V.</creatorcontrib><creatorcontrib>Korystov, Yuri N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Drinyaev, Victor A.</au><au>Mosin, Vladimir A.</au><au>Kruglyak, Elena B.</au><au>Novik, Tamara S.</au><au>Sterlina, Tatiana S.</au><au>Ermakova, Natalia V.</au><au>Kublik, Ludmila N.</au><au>Levitman, Maria Kh</au><au>Shaposhnikova, Vera V.</au><au>Korystov, Yuri N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antitumor effect of avermectins</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2004-10-06</date><risdate>2004</risdate><volume>501</volume><issue>1</issue><spage>19</spage><epage>23</epage><pages>19-23</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>The effect of a mixture of naturally occurring aversectin C and avermectin B
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| subjects | Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Avermectin Carcinoma, Ehrlich Tumor - drug therapy Cell Proliferation - drug effects Dose-Response Relationship, Drug Ivermectin - analogs & derivatives Ivermectin - pharmacology Ivermectin - therapeutic use Leukemia P388 - drug therapy Male Melanoma, Experimental - drug therapy Mice Mice, Inbred C57BL Mice, Inbred DBA Mouse Tumor growth |
| title | Antitumor effect of avermectins |
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