GLP-1 and Adiponectin: Effect of Weight Loss After Dietary Restriction and Gastric Bypass in Morbidly Obese Patients with Normal and Abnormal Glucose Metabolism
Background It has been proposed that there is improvement in glucose and insulin metabolism after weight loss in patients who underwent diet restriction and bariatric surgery. Methods Eleven normal glucose tolerant (NGT) morbidly obese patients [body mass index (BMI), 46.1 ± 2.27 g/m 2 ] and eight a...
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| Veröffentlicht in: | Obesity surgery 2009-03, Vol.19 (3), p.313-320 |
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| creator | de Carvalho, Camila Puzzi Marin, Daniela Miguel de Souza, Aglécio Luiz Pareja, José Carlos Chaim, Elintom Adami de Barros Mazon, Silvia da Silva, Conceição Aparecida Geloneze, Bruno Muscelli, Elza Alegre, Sarah Monte |
| description | Background
It has been proposed that there is improvement in glucose and insulin metabolism after weight loss in patients who underwent diet restriction and bariatric surgery.
Methods
Eleven normal glucose tolerant (NGT) morbidly obese patients [body mass index (BMI), 46.1 ± 2.27 g/m
2
] and eight abnormal glucose metabolism (AGM) obese patients (BMI, 51.20 kg/m
2
) were submitted to diet-restriction and bariatric surgery. Prospective study on weight loss changes, over the glucose, insulin metabolism, glucagon-like peptide-1 (GLP-1), and adiponectin levels were evaluated by oral glucose tolerance test during three periods: T1 (first evaluation), T2 (pre-surgery), and T3 (9 months after surgery).
Results
Insulin levels improved after surgery. T1 was 131.1 ± 17.60 pmol/l in the NGT group and 197.57 ± 57.94 pmol/l in the AGM group, and T3 was 72.48 ± 3.67 pmol/l in the NGT group and 61.2 ± 9.33 pmol/l in the AGM group. The major reduction was at the first hour of the glucose load as well as fasting levels. At 9 months after surgery (T3), GLP-1 levels at 30 and 60 min had significantly increased in both groups. It was observed that the AGM group had higher levels of GLP-1 at 30 min (34.06 ± 6.18 pmol/l) when compared to the NGT group (22.69 ± 4.04 pmol/l). Homeostasis model assessment of insulin resistance from the NGT and AGM groups had a significant reduction at periods T3 in relation to T1 and T2. Adiponectin levels had increased concentration in both groups before and after surgical weight loss. However, it did not have any statistical difference between periods T1 vs. T2.
Conclusions
Weight loss by surgery leads to improvement in the metabolism of carbohydrates in relation to sensitivity to the insulin, contributing to the reduction of type 2 diabetes incidence. This improvement also was expressed by the improvement of the levels of adiponectin and GLP-1. |
| doi_str_mv | 10.1007/s11695-008-9678-5 |
| format | Article |
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It has been proposed that there is improvement in glucose and insulin metabolism after weight loss in patients who underwent diet restriction and bariatric surgery.
Methods
Eleven normal glucose tolerant (NGT) morbidly obese patients [body mass index (BMI), 46.1 ± 2.27 g/m
2
] and eight abnormal glucose metabolism (AGM) obese patients (BMI, 51.20 kg/m
2
) were submitted to diet-restriction and bariatric surgery. Prospective study on weight loss changes, over the glucose, insulin metabolism, glucagon-like peptide-1 (GLP-1), and adiponectin levels were evaluated by oral glucose tolerance test during three periods: T1 (first evaluation), T2 (pre-surgery), and T3 (9 months after surgery).
Results
Insulin levels improved after surgery. T1 was 131.1 ± 17.60 pmol/l in the NGT group and 197.57 ± 57.94 pmol/l in the AGM group, and T3 was 72.48 ± 3.67 pmol/l in the NGT group and 61.2 ± 9.33 pmol/l in the AGM group. The major reduction was at the first hour of the glucose load as well as fasting levels. At 9 months after surgery (T3), GLP-1 levels at 30 and 60 min had significantly increased in both groups. It was observed that the AGM group had higher levels of GLP-1 at 30 min (34.06 ± 6.18 pmol/l) when compared to the NGT group (22.69 ± 4.04 pmol/l). Homeostasis model assessment of insulin resistance from the NGT and AGM groups had a significant reduction at periods T3 in relation to T1 and T2. Adiponectin levels had increased concentration in both groups before and after surgical weight loss. However, it did not have any statistical difference between periods T1 vs. T2.
Conclusions
Weight loss by surgery leads to improvement in the metabolism of carbohydrates in relation to sensitivity to the insulin, contributing to the reduction of type 2 diabetes incidence. This improvement also was expressed by the improvement of the levels of adiponectin and GLP-1.</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-008-9678-5</identifier><identifier>PMID: 18815849</identifier><language>eng</language><publisher>New York: Springer New York</publisher><subject>Adiponectin - blood ; Adult ; Blood Glucose - metabolism ; Body Mass Index ; Case-Control Studies ; Clinical outcomes ; Cohort Studies ; Diet ; Female ; Gastric Bypass ; Gastrointestinal surgery ; Glucagon-Like Peptide 1 - blood ; Glucose ; Glucose Metabolism Disorders - blood ; Glucose Metabolism Disorders - complications ; Glucose Metabolism Disorders - surgery ; Humans ; Insulin ; Insulin Resistance - physiology ; Male ; Medicine ; Medicine & Public Health ; Metabolism ; Middle Aged ; Obesity ; Obesity, Morbid - blood ; Obesity, Morbid - complications ; Obesity, Morbid - therapy ; Research Article ; Surgery ; Treatment Outcome ; Weight control ; Weight Loss - physiology</subject><ispartof>Obesity surgery, 2009-03, Vol.19 (3), p.313-320</ispartof><rights>Springer Science + Business Media, LLC 2008</rights><rights>Springer Science + Business Media, LLC 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-f64021f5406335eace13e55130966a4eebed1d6bfd7f1c3e1c1c31ed6dbb2cf93</citedby><cites>FETCH-LOGICAL-c402t-f64021f5406335eace13e55130966a4eebed1d6bfd7f1c3e1c1c31ed6dbb2cf93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11695-008-9678-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11695-008-9678-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18815849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Carvalho, Camila Puzzi</creatorcontrib><creatorcontrib>Marin, Daniela Miguel</creatorcontrib><creatorcontrib>de Souza, Aglécio Luiz</creatorcontrib><creatorcontrib>Pareja, José Carlos</creatorcontrib><creatorcontrib>Chaim, Elintom Adami</creatorcontrib><creatorcontrib>de Barros Mazon, Silvia</creatorcontrib><creatorcontrib>da Silva, Conceição Aparecida</creatorcontrib><creatorcontrib>Geloneze, Bruno</creatorcontrib><creatorcontrib>Muscelli, Elza</creatorcontrib><creatorcontrib>Alegre, Sarah Monte</creatorcontrib><title>GLP-1 and Adiponectin: Effect of Weight Loss After Dietary Restriction and Gastric Bypass in Morbidly Obese Patients with Normal and Abnormal Glucose Metabolism</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><addtitle>Obes Surg</addtitle><description>Background
It has been proposed that there is improvement in glucose and insulin metabolism after weight loss in patients who underwent diet restriction and bariatric surgery.
Methods
Eleven normal glucose tolerant (NGT) morbidly obese patients [body mass index (BMI), 46.1 ± 2.27 g/m
2
] and eight abnormal glucose metabolism (AGM) obese patients (BMI, 51.20 kg/m
2
) were submitted to diet-restriction and bariatric surgery. Prospective study on weight loss changes, over the glucose, insulin metabolism, glucagon-like peptide-1 (GLP-1), and adiponectin levels were evaluated by oral glucose tolerance test during three periods: T1 (first evaluation), T2 (pre-surgery), and T3 (9 months after surgery).
Results
Insulin levels improved after surgery. T1 was 131.1 ± 17.60 pmol/l in the NGT group and 197.57 ± 57.94 pmol/l in the AGM group, and T3 was 72.48 ± 3.67 pmol/l in the NGT group and 61.2 ± 9.33 pmol/l in the AGM group. The major reduction was at the first hour of the glucose load as well as fasting levels. At 9 months after surgery (T3), GLP-1 levels at 30 and 60 min had significantly increased in both groups. It was observed that the AGM group had higher levels of GLP-1 at 30 min (34.06 ± 6.18 pmol/l) when compared to the NGT group (22.69 ± 4.04 pmol/l). Homeostasis model assessment of insulin resistance from the NGT and AGM groups had a significant reduction at periods T3 in relation to T1 and T2. Adiponectin levels had increased concentration in both groups before and after surgical weight loss. However, it did not have any statistical difference between periods T1 vs. T2.
Conclusions
Weight loss by surgery leads to improvement in the metabolism of carbohydrates in relation to sensitivity to the insulin, contributing to the reduction of type 2 diabetes incidence. This improvement also was expressed by the improvement of the levels of adiponectin and GLP-1.</description><subject>Adiponectin - blood</subject><subject>Adult</subject><subject>Blood Glucose - metabolism</subject><subject>Body Mass Index</subject><subject>Case-Control Studies</subject><subject>Clinical outcomes</subject><subject>Cohort Studies</subject><subject>Diet</subject><subject>Female</subject><subject>Gastric Bypass</subject><subject>Gastrointestinal surgery</subject><subject>Glucagon-Like Peptide 1 - blood</subject><subject>Glucose</subject><subject>Glucose Metabolism Disorders - blood</subject><subject>Glucose Metabolism Disorders - complications</subject><subject>Glucose Metabolism Disorders - surgery</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin Resistance - physiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity, Morbid - blood</subject><subject>Obesity, Morbid - complications</subject><subject>Obesity, Morbid - therapy</subject><subject>Research Article</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Weight control</subject><subject>Weight Loss - physiology</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc-KFDEQxoMo7rj6AF4keBAvrakkne54G9d1FGbdRRSPof9UdrN0J2PSjczb-KhmtgcUQS-pFPWrr6j6CHkK7BUwVr1OAEqXBWN1oVVVF-U9soIqZ0zy-j5ZMa1YUWsuTsijlG4Z46A4f0hOoK6hrKVekZ-b7VUBtPE9XfduFzx2k_Nv6Lm1-UeDpd_QXd9MdBtSoms7YaTvHE5N3NPPmKboMh_8ncCmucvp2_2uybDz9CLE1vXDnl62mJBeNZNDPyX6w0039FOIYzMso1u_JJth7kImL_KENgwujY_JA9sMCZ8c4yn5-v78y9mHYnu5-Xi23hadZHwqrMoBbCmZEqLEpkMQWJYg8g1UIxFb7KFXre0rC51A6PIL2Ku-bXlntTglLxbdXQzf57yZGV3qcBgaj2FORiktgdcygy__C0ItKsFlJQ-az_9Cb8McfV7DgBa61FqqDMECdTGfOKI1u-jGfF8DzBxsNovNJttsDjabMvc8OwrP7Yj9746jrxngC5ByyV9j_GPyP1V_ARb6s8w</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>de Carvalho, Camila Puzzi</creator><creator>Marin, Daniela Miguel</creator><creator>de Souza, Aglécio Luiz</creator><creator>Pareja, José Carlos</creator><creator>Chaim, Elintom Adami</creator><creator>de Barros Mazon, Silvia</creator><creator>da Silva, Conceição Aparecida</creator><creator>Geloneze, Bruno</creator><creator>Muscelli, Elza</creator><creator>Alegre, Sarah Monte</creator><general>Springer New York</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>20090301</creationdate><title>GLP-1 and Adiponectin: Effect of Weight Loss After Dietary Restriction and Gastric Bypass in Morbidly Obese Patients with Normal and Abnormal Glucose Metabolism</title><author>de Carvalho, Camila Puzzi ; Marin, Daniela Miguel ; de Souza, Aglécio Luiz ; Pareja, José Carlos ; Chaim, Elintom Adami ; de Barros Mazon, Silvia ; da Silva, Conceição Aparecida ; Geloneze, Bruno ; Muscelli, Elza ; Alegre, Sarah Monte</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-f64021f5406335eace13e55130966a4eebed1d6bfd7f1c3e1c1c31ed6dbb2cf93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adiponectin - blood</topic><topic>Adult</topic><topic>Blood Glucose - metabolism</topic><topic>Body Mass Index</topic><topic>Case-Control Studies</topic><topic>Clinical outcomes</topic><topic>Cohort Studies</topic><topic>Diet</topic><topic>Female</topic><topic>Gastric Bypass</topic><topic>Gastrointestinal surgery</topic><topic>Glucagon-Like Peptide 1 - blood</topic><topic>Glucose</topic><topic>Glucose Metabolism Disorders - blood</topic><topic>Glucose Metabolism Disorders - complications</topic><topic>Glucose Metabolism Disorders - surgery</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin Resistance - physiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity, Morbid - blood</topic><topic>Obesity, Morbid - complications</topic><topic>Obesity, Morbid - therapy</topic><topic>Research Article</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><topic>Weight control</topic><topic>Weight Loss - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Carvalho, Camila Puzzi</creatorcontrib><creatorcontrib>Marin, Daniela Miguel</creatorcontrib><creatorcontrib>de Souza, Aglécio Luiz</creatorcontrib><creatorcontrib>Pareja, José Carlos</creatorcontrib><creatorcontrib>Chaim, Elintom Adami</creatorcontrib><creatorcontrib>de Barros Mazon, Silvia</creatorcontrib><creatorcontrib>da Silva, Conceição Aparecida</creatorcontrib><creatorcontrib>Geloneze, Bruno</creatorcontrib><creatorcontrib>Muscelli, Elza</creatorcontrib><creatorcontrib>Alegre, Sarah Monte</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Carvalho, Camila Puzzi</au><au>Marin, Daniela Miguel</au><au>de Souza, Aglécio Luiz</au><au>Pareja, José Carlos</au><au>Chaim, Elintom Adami</au><au>de Barros Mazon, Silvia</au><au>da Silva, Conceição Aparecida</au><au>Geloneze, Bruno</au><au>Muscelli, Elza</au><au>Alegre, Sarah Monte</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GLP-1 and Adiponectin: Effect of Weight Loss After Dietary Restriction and Gastric Bypass in Morbidly Obese Patients with Normal and Abnormal Glucose Metabolism</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><addtitle>Obes Surg</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>19</volume><issue>3</issue><spage>313</spage><epage>320</epage><pages>313-320</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>Background
It has been proposed that there is improvement in glucose and insulin metabolism after weight loss in patients who underwent diet restriction and bariatric surgery.
Methods
Eleven normal glucose tolerant (NGT) morbidly obese patients [body mass index (BMI), 46.1 ± 2.27 g/m
2
] and eight abnormal glucose metabolism (AGM) obese patients (BMI, 51.20 kg/m
2
) were submitted to diet-restriction and bariatric surgery. Prospective study on weight loss changes, over the glucose, insulin metabolism, glucagon-like peptide-1 (GLP-1), and adiponectin levels were evaluated by oral glucose tolerance test during three periods: T1 (first evaluation), T2 (pre-surgery), and T3 (9 months after surgery).
Results
Insulin levels improved after surgery. T1 was 131.1 ± 17.60 pmol/l in the NGT group and 197.57 ± 57.94 pmol/l in the AGM group, and T3 was 72.48 ± 3.67 pmol/l in the NGT group and 61.2 ± 9.33 pmol/l in the AGM group. The major reduction was at the first hour of the glucose load as well as fasting levels. At 9 months after surgery (T3), GLP-1 levels at 30 and 60 min had significantly increased in both groups. It was observed that the AGM group had higher levels of GLP-1 at 30 min (34.06 ± 6.18 pmol/l) when compared to the NGT group (22.69 ± 4.04 pmol/l). Homeostasis model assessment of insulin resistance from the NGT and AGM groups had a significant reduction at periods T3 in relation to T1 and T2. Adiponectin levels had increased concentration in both groups before and after surgical weight loss. However, it did not have any statistical difference between periods T1 vs. T2.
Conclusions
Weight loss by surgery leads to improvement in the metabolism of carbohydrates in relation to sensitivity to the insulin, contributing to the reduction of type 2 diabetes incidence. This improvement also was expressed by the improvement of the levels of adiponectin and GLP-1.</abstract><cop>New York</cop><pub>Springer New York</pub><pmid>18815849</pmid><doi>10.1007/s11695-008-9678-5</doi><tpages>8</tpages></addata></record> |
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| ispartof | Obesity surgery, 2009-03, Vol.19 (3), p.313-320 |
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| subjects | Adiponectin - blood Adult Blood Glucose - metabolism Body Mass Index Case-Control Studies Clinical outcomes Cohort Studies Diet Female Gastric Bypass Gastrointestinal surgery Glucagon-Like Peptide 1 - blood Glucose Glucose Metabolism Disorders - blood Glucose Metabolism Disorders - complications Glucose Metabolism Disorders - surgery Humans Insulin Insulin Resistance - physiology Male Medicine Medicine & Public Health Metabolism Middle Aged Obesity Obesity, Morbid - blood Obesity, Morbid - complications Obesity, Morbid - therapy Research Article Surgery Treatment Outcome Weight control Weight Loss - physiology |
| title | GLP-1 and Adiponectin: Effect of Weight Loss After Dietary Restriction and Gastric Bypass in Morbidly Obese Patients with Normal and Abnormal Glucose Metabolism |
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