The bronchodilators 8-iso-prostaglandin E2 and prostaglandin E2 induce K+ current suppression via thromboxane A2 receptors in porcine tracheal smooth muscle

We examined relaxations and changes in K(+) current evoked by 8-iso-prostaglandin E(2) and prostaglandin E(2) in porcine tracheal smooth muscle. Both autacoids completely reversed cholinergic tone; blockade of thromboxane A(2) receptors had no effect on relaxations to either compound. 8-iso-prostagl...

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Veröffentlicht in:	European journal of pharmacology 2004-10, Vol.501 (1-3), p.179-184
Hauptverfasser:	HELLI, Peter B, CATALLI, Adriana, JANSSEN, Luke J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bronchodilator Agents - pharmacology Dinoprostone - analogs & derivatives Dinoprostone - pharmacology Dose-Response Relationship, Drug In Vitro Techniques Isoprostanes - pharmacology Medical sciences Muscle, Smooth - drug effects Muscle, Smooth - physiology Pharmacology. Drug treatments Potassium Channels - metabolism Receptors, Thromboxane A2, Prostaglandin H2 - physiology Swine Trachea - drug effects Trachea - physiology
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