Insulin sensitivity in growth hormone-deficient children: influence of replacement treatment
Summary objective In adults, excessive GH secretion may lead to secondary diabetes mellitus, while prolonged GH treatment may accelerate the onset of type 2 diabetes mellitus in predisposed children. The aim of the study was to evaluate insulin sensitivity (IS) and glucose tolerance (GT) in a group...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2004-10, Vol.61 (4), p.473-477 |
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| creator | Radetti, Giorgio Pasquino, Bruno Gottardi, Elena Contadin, Isabella Boscolo Rigon, Franco Aimaretti, Gianluca |
| description | Summary
objective In adults, excessive GH secretion may lead to secondary diabetes mellitus, while prolonged GH treatment may accelerate the onset of type 2 diabetes mellitus in predisposed children. The aim of the study was to evaluate insulin sensitivity (IS) and glucose tolerance (GT) in a group of GH‐deficient children treated with GH for a period of 6 years.
patients and design One hundred and twenty‐eight children (40 females, 88 males) were included in the study. At the beginning of treatment chronological age was 8·9 ± 3·2 years, height standard deviation score (SDS) −2·43 ± 0·90 and body mass index (BMI) SDS 0·18 ± 1·60. At the end of the study chronological age was 13·0 ± 2·9 years, height SDS −1·24 ± 1·27 and BMI SDS 0·23 ± 1·54. GH was administered at a mean weekly dosage of 0·3 mg/kg, injected subcutaneously over 6–7 days. GT was assessed according to the criteria of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. IS was evaluated with the quantitative insulin sensitivity check index (QUICKI).
results No cases of impaired GT or diabetes were recorded during the follow‐up period. IS, already lower than in controls before starting treatment with GH, decreased significantly during the first year of therapy (QUICKI: 0·346 ± 0·033 vs. 0·355 ± 0·044, P |
| doi_str_mv | 10.1111/j.1365-2265.2004.02113.x |
| format | Article |
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objective In adults, excessive GH secretion may lead to secondary diabetes mellitus, while prolonged GH treatment may accelerate the onset of type 2 diabetes mellitus in predisposed children. The aim of the study was to evaluate insulin sensitivity (IS) and glucose tolerance (GT) in a group of GH‐deficient children treated with GH for a period of 6 years.
patients and design One hundred and twenty‐eight children (40 females, 88 males) were included in the study. At the beginning of treatment chronological age was 8·9 ± 3·2 years, height standard deviation score (SDS) −2·43 ± 0·90 and body mass index (BMI) SDS 0·18 ± 1·60. At the end of the study chronological age was 13·0 ± 2·9 years, height SDS −1·24 ± 1·27 and BMI SDS 0·23 ± 1·54. GH was administered at a mean weekly dosage of 0·3 mg/kg, injected subcutaneously over 6–7 days. GT was assessed according to the criteria of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. IS was evaluated with the quantitative insulin sensitivity check index (QUICKI).
results No cases of impaired GT or diabetes were recorded during the follow‐up period. IS, already lower than in controls before starting treatment with GH, decreased significantly during the first year of therapy (QUICKI: 0·346 ± 0·033 vs. 0·355 ± 0·044, P < 0·05), with no further decrease in the following years. No correlation was found between QUICKI, BMI, years of treatment and onset of puberty.
conclusions GH treatment in GH‐deficient children does not lead to an impaired GT or type 2 diabetes mellitus, although it does significantly decrease IS.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2004.02113.x</identifier><identifier>PMID: 15473880</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Biological and medical sciences ; Blood Glucose - analysis ; Case-Control Studies ; Chi-Square Distribution ; Child ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Glucose Tolerance Test ; Growth Hormone - deficiency ; Growth Hormone - therapeutic use ; Humans ; Insulin - blood ; Insulin Resistance ; Male ; Medical sciences ; Vertebrates: endocrinology</subject><ispartof>Clinical endocrinology (Oxford), 2004-10, Vol.61 (4), p.473-477</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Oct 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4603-43c8b40160b3b86ebc0dab13e7da51a8495bb4fa805f727662ca6b46e14b82043</citedby><cites>FETCH-LOGICAL-c4603-43c8b40160b3b86ebc0dab13e7da51a8495bb4fa805f727662ca6b46e14b82043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2265.2004.02113.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2265.2004.02113.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16193146$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15473880$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Radetti, Giorgio</creatorcontrib><creatorcontrib>Pasquino, Bruno</creatorcontrib><creatorcontrib>Gottardi, Elena</creatorcontrib><creatorcontrib>Contadin, Isabella Boscolo</creatorcontrib><creatorcontrib>Rigon, Franco</creatorcontrib><creatorcontrib>Aimaretti, Gianluca</creatorcontrib><title>Insulin sensitivity in growth hormone-deficient children: influence of replacement treatment</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Summary
objective In adults, excessive GH secretion may lead to secondary diabetes mellitus, while prolonged GH treatment may accelerate the onset of type 2 diabetes mellitus in predisposed children. The aim of the study was to evaluate insulin sensitivity (IS) and glucose tolerance (GT) in a group of GH‐deficient children treated with GH for a period of 6 years.
patients and design One hundred and twenty‐eight children (40 females, 88 males) were included in the study. At the beginning of treatment chronological age was 8·9 ± 3·2 years, height standard deviation score (SDS) −2·43 ± 0·90 and body mass index (BMI) SDS 0·18 ± 1·60. At the end of the study chronological age was 13·0 ± 2·9 years, height SDS −1·24 ± 1·27 and BMI SDS 0·23 ± 1·54. GH was administered at a mean weekly dosage of 0·3 mg/kg, injected subcutaneously over 6–7 days. GT was assessed according to the criteria of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. IS was evaluated with the quantitative insulin sensitivity check index (QUICKI).
results No cases of impaired GT or diabetes were recorded during the follow‐up period. IS, already lower than in controls before starting treatment with GH, decreased significantly during the first year of therapy (QUICKI: 0·346 ± 0·033 vs. 0·355 ± 0·044, P < 0·05), with no further decrease in the following years. No correlation was found between QUICKI, BMI, years of treatment and onset of puberty.
conclusions GH treatment in GH‐deficient children does not lead to an impaired GT or type 2 diabetes mellitus, although it does significantly decrease IS.</description><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Case-Control Studies</subject><subject>Chi-Square Distribution</subject><subject>Child</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose Tolerance Test</subject><subject>Growth Hormone - deficiency</subject><subject>Growth Hormone - therapeutic use</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Vertebrates: endocrinology</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkFGL1DAQx4so3t7pV5Ai6FvrpEnTVPDhXO72Ds4T5MQXISTp1M3apmvServf3tRd7sAn52Um5Pcfhl-SpARyEuvdJieUl1lR8DIvAFgOBSE03z1JFg8fT5MFUIAMOGcnyWkIGwAoBVTPkxNSsooKAYvk-7ULU2ddGtAFO9rfdtyn8fnDD_fjOl0Pvh8cZg221lh0Y2rWtms8uveRarsJncF0aFOP204Z7Gdk9KjGeXqRPGtVF_DlsZ8lXy8v7pZX2c3n1fXy_CYzjAPNGDVCMyAcNNWCozbQKE0oVo0qiRKsLrVmrRJQtlVRcV4YxTXjSJgWBTB6lrw97N364deEYZS9DQa7TjkcpiA5rxlAPYOv_wE3w-RdvE2SOvogtCwiJA6Q8UMIHlu59bZXfi8JyFm_3MjZspwty1m__Ktf7mL01XH_pHtsHoNH3xF4cwRUMKprvXLGhkeOk5oSxiP34cDd2w73_32AXF7czlPMZ4e8DSPuHvLK_5S8olUpv92u5JeP9d2nK7KSgv4BT6SvqA</recordid><startdate>200410</startdate><enddate>200410</enddate><creator>Radetti, Giorgio</creator><creator>Pasquino, Bruno</creator><creator>Gottardi, Elena</creator><creator>Contadin, Isabella Boscolo</creator><creator>Rigon, Franco</creator><creator>Aimaretti, Gianluca</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>200410</creationdate><title>Insulin sensitivity in growth hormone-deficient children: influence of replacement treatment</title><author>Radetti, Giorgio ; Pasquino, Bruno ; Gottardi, Elena ; Contadin, Isabella Boscolo ; Rigon, Franco ; Aimaretti, Gianluca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4603-43c8b40160b3b86ebc0dab13e7da51a8495bb4fa805f727662ca6b46e14b82043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Case-Control Studies</topic><topic>Chi-Square Distribution</topic><topic>Child</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose Tolerance Test</topic><topic>Growth Hormone - deficiency</topic><topic>Growth Hormone - therapeutic use</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Radetti, Giorgio</creatorcontrib><creatorcontrib>Pasquino, Bruno</creatorcontrib><creatorcontrib>Gottardi, Elena</creatorcontrib><creatorcontrib>Contadin, Isabella Boscolo</creatorcontrib><creatorcontrib>Rigon, Franco</creatorcontrib><creatorcontrib>Aimaretti, Gianluca</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Radetti, Giorgio</au><au>Pasquino, Bruno</au><au>Gottardi, Elena</au><au>Contadin, Isabella Boscolo</au><au>Rigon, Franco</au><au>Aimaretti, Gianluca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin sensitivity in growth hormone-deficient children: influence of replacement treatment</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2004-10</date><risdate>2004</risdate><volume>61</volume><issue>4</issue><spage>473</spage><epage>477</epage><pages>473-477</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
objective In adults, excessive GH secretion may lead to secondary diabetes mellitus, while prolonged GH treatment may accelerate the onset of type 2 diabetes mellitus in predisposed children. The aim of the study was to evaluate insulin sensitivity (IS) and glucose tolerance (GT) in a group of GH‐deficient children treated with GH for a period of 6 years.
patients and design One hundred and twenty‐eight children (40 females, 88 males) were included in the study. At the beginning of treatment chronological age was 8·9 ± 3·2 years, height standard deviation score (SDS) −2·43 ± 0·90 and body mass index (BMI) SDS 0·18 ± 1·60. At the end of the study chronological age was 13·0 ± 2·9 years, height SDS −1·24 ± 1·27 and BMI SDS 0·23 ± 1·54. GH was administered at a mean weekly dosage of 0·3 mg/kg, injected subcutaneously over 6–7 days. GT was assessed according to the criteria of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. IS was evaluated with the quantitative insulin sensitivity check index (QUICKI).
results No cases of impaired GT or diabetes were recorded during the follow‐up period. IS, already lower than in controls before starting treatment with GH, decreased significantly during the first year of therapy (QUICKI: 0·346 ± 0·033 vs. 0·355 ± 0·044, P < 0·05), with no further decrease in the following years. No correlation was found between QUICKI, BMI, years of treatment and onset of puberty.
conclusions GH treatment in GH‐deficient children does not lead to an impaired GT or type 2 diabetes mellitus, although it does significantly decrease IS.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15473880</pmid><doi>10.1111/j.1365-2265.2004.02113.x</doi><tpages>5</tpages></addata></record> |
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| ispartof | Clinical endocrinology (Oxford), 2004-10, Vol.61 (4), p.473-477 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Biological and medical sciences Blood Glucose - analysis Case-Control Studies Chi-Square Distribution Child Endocrinopathies Female Fundamental and applied biological sciences. Psychology Glucose Tolerance Test Growth Hormone - deficiency Growth Hormone - therapeutic use Humans Insulin - blood Insulin Resistance Male Medical sciences Vertebrates: endocrinology |
| title | Insulin sensitivity in growth hormone-deficient children: influence of replacement treatment |
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