Nuclear Receptor Signaling in the Control of Cholesterol Homeostasis: Have the Orphans Found a Home?

Cholesterol is essential for all mammalian cells. Cellular cholesterol requirements are met through de novo synthesis and uptake of plasma lipoproteins, homeostatic responses that are transcriptionally regulated by the sterol regulatory element-binding proteins (SREBPs). To prevent cytotoxicity attr...

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Veröffentlicht in:	Circulation research 2004-10, Vol.95 (7), p.660-670
1. Verfasser:	Ory, Daniel S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-Binding Cassette Transporters - physiology Bile Acids and Salts - metabolism Biological and medical sciences Cholesterol - metabolism Dietary Fats - pharmacokinetics DNA-Binding Proteins - physiology Fatty Acids - biosynthesis Fundamental and applied biological sciences. Psychology Hepatocytes - metabolism Homeostasis - physiology Humans Intestinal Absorption Intestinal Mucosa - metabolism Lipoproteins - biosynthesis Liver - metabolism Liver X Receptors Macrophages - physiology Mice Mice, Knockout Multigene Family Orphan Nuclear Receptors Receptors, Cytoplasmic and Nuclear - physiology Signal Transduction - physiology Sterols - metabolism Sterols - pharmacokinetics Transcription Factors - physiology Vertebrates: cardiovascular system
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