ATR (AT mutated Rad3 related) activity stabilizes Cdc6 and delays G2/M-phase entry during hydroxyurea-induced S-phase arrest of HeLa cells

The Cdc6 protein, a key DNA replication initiation factor, contributes to the long-term maintenance of the S-phase checkpoint by anchoring the Rad3–Rad26 complex to chromatin. Here, we demonstrate that ATR (AT mutated and Rad3 related) activity is essential for maintaining high chromatin levels of t...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2009-06, Vol.41 (6), p.1410-1420
Hauptverfasser:	Liu, Linhua, Choi, Jae Hyuk, Yim, Hyungshin, Choi, Joon Seok, Park, Byoung Duck, Cho, Seung Ju, Lee, Seung Ki
Format:	Artikel
Sprache:	eng
Schlagworte:	Ataxia Telangiectasia Mutated Proteins ATR Cdc6 Cell Cycle - drug effects Cell Cycle - genetics Cell Cycle Proteins - metabolism Cell Division - drug effects Cell Line, Tumor Cell Proliferation - drug effects Checkpoint HeLa Cells Humans Hydroxyurea Hydroxyurea - pharmacology Immunoblotting Nuclear Proteins - metabolism Phosphorylation Protein-Serine-Threonine Kinases - metabolism S Phase - drug effects
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