Transient Myeloproliferative Disorder Causing a Vesiculopustular Eruption in a Phenotypically Normal Neonate
: We report an unusual congenital vesiculopustular eruption arising in a neonate as the result of the transient myeloproliferative disorder (TMD) associated with trisomy 21. In this instance, the neonate was phenotypically normal, making the diagnosis more elusive. Initially the lesions were clinic...
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| Veröffentlicht in: | Pediatric dermatology 2004-09, Vol.21 (5), p.551-554 |
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| creator | Solky, Benjamin A. Yang, F. Clarissa Xu, Xiaowei Levins, Paul |
| description | : We report an unusual congenital vesiculopustular eruption arising in a neonate as the result of the transient myeloproliferative disorder (TMD) associated with trisomy 21. In this instance, the neonate was phenotypically normal, making the diagnosis more elusive. Initially the lesions were clinically suspicious for herpetic infection. The clinical scenario quickly became highly suggestive of leukemia cutis, given the infant's extremely high white blood cell count. Further examination revealed trisomy 21 in the leukemic cells and disomy 21 in the buccal keratinocytes, and a diagnosis of self‐resolving TMD was made. Biopsy specimens of the lesions showed a sparse, perivascular, atypical, mononuclear infiltrate. We suggest that examination for a TMD be undertaken in neonates with a vesiculopustular eruption and leukemic white blood cell counts. |
| doi_str_mv | 10.1111/j.0736-8046.2004.21505.x |
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Clarissa</creatorcontrib><creatorcontrib>Xu, Xiaowei</creatorcontrib><creatorcontrib>Levins, Paul</creatorcontrib><title>Transient Myeloproliferative Disorder Causing a Vesiculopustular Eruption in a Phenotypically Normal Neonate</title><title>Pediatric dermatology</title><addtitle>Pediatr Dermatol</addtitle><description>: We report an unusual congenital vesiculopustular eruption arising in a neonate as the result of the transient myeloproliferative disorder (TMD) associated with trisomy 21. In this instance, the neonate was phenotypically normal, making the diagnosis more elusive. Initially the lesions were clinically suspicious for herpetic infection. The clinical scenario quickly became highly suggestive of leukemia cutis, given the infant's extremely high white blood cell count. Further examination revealed trisomy 21 in the leukemic cells and disomy 21 in the buccal keratinocytes, and a diagnosis of self‐resolving TMD was made. Biopsy specimens of the lesions showed a sparse, perivascular, atypical, mononuclear infiltrate. We suggest that examination for a TMD be undertaken in neonates with a vesiculopustular eruption and leukemic white blood cell counts.</description><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Diagnosis, Differential</subject><subject>Down Syndrome</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Leukocyte Count</subject><subject>Medical sciences</subject><subject>Myeloproliferative Disorders - blood</subject><subject>Myeloproliferative Disorders - complications</subject><subject>Myeloproliferative Disorders - diagnosis</subject><subject>Phenotype</subject><subject>Skin Diseases, Vesiculobullous - etiology</subject><subject>Skin Diseases, Vesiculobullous - pathology</subject><issn>0736-8046</issn><issn>1525-1470</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1P3DAQQK2Kqiy0f6HypdwS_JE49qUSWraARCkH2qvlTcatV954sRNK_j0OuyrXzmVGmjdjz0MIU1LSHOebkjRcFJJUomSEVCWjNanL53doQWtWF7RqyBFa_IOO0UlKG0KIFIJ-QMe0rgRtBFkg_xBNnxz0A_4-gQ-7GLyzEM3gngBfuhRiBxEvzZhc_xsb_AuSa8cMjmkYvYl4Fcfd4EKPXZ_b93-gD8O0c63xfsJ3IW6Nx3cQejPAR_TeGp_g0yGfop_fVg_L6-L2x9XN8uK2aLkSdcGF6ZSilDVdV8nKMsuIZNwS3gARSphKrVsG3FKuatopw9fWUiGYFBJaa_kpOtvvzdc8jpAGvXWpBe9ND2FMWgjFGyJlBuUebGNIKYLVu-i2Jk6aEj2b1hs9S9SzRD2b1q-m9XMe_Xx4Y1xvoXsbPKjNwJcDYFKWYbPn1qU3TjCuKjVzX_fcX-dh-u8P6PvL1WvJXwCs65tL</recordid><startdate>200409</startdate><enddate>200409</enddate><creator>Solky, Benjamin A.</creator><creator>Yang, F. 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Clarissa ; Xu, Xiaowei ; Levins, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3965-36ad991127dd484f2f20823f037e0696a49bc2e3f13951d9a3bff1662868ecff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>Diagnosis, Differential</topic><topic>Down Syndrome</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Leukocyte Count</topic><topic>Medical sciences</topic><topic>Myeloproliferative Disorders - blood</topic><topic>Myeloproliferative Disorders - complications</topic><topic>Myeloproliferative Disorders - diagnosis</topic><topic>Phenotype</topic><topic>Skin Diseases, Vesiculobullous - etiology</topic><topic>Skin Diseases, Vesiculobullous - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Solky, Benjamin A.</creatorcontrib><creatorcontrib>Yang, F. Clarissa</creatorcontrib><creatorcontrib>Xu, Xiaowei</creatorcontrib><creatorcontrib>Levins, Paul</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Solky, Benjamin A.</au><au>Yang, F. Clarissa</au><au>Xu, Xiaowei</au><au>Levins, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transient Myeloproliferative Disorder Causing a Vesiculopustular Eruption in a Phenotypically Normal Neonate</atitle><jtitle>Pediatric dermatology</jtitle><addtitle>Pediatr Dermatol</addtitle><date>2004-09</date><risdate>2004</risdate><volume>21</volume><issue>5</issue><spage>551</spage><epage>554</epage><pages>551-554</pages><issn>0736-8046</issn><eissn>1525-1470</eissn><coden>PEDRDQ</coden><abstract>: We report an unusual congenital vesiculopustular eruption arising in a neonate as the result of the transient myeloproliferative disorder (TMD) associated with trisomy 21. In this instance, the neonate was phenotypically normal, making the diagnosis more elusive. Initially the lesions were clinically suspicious for herpetic infection. The clinical scenario quickly became highly suggestive of leukemia cutis, given the infant's extremely high white blood cell count. Further examination revealed trisomy 21 in the leukemic cells and disomy 21 in the buccal keratinocytes, and a diagnosis of self‐resolving TMD was made. Biopsy specimens of the lesions showed a sparse, perivascular, atypical, mononuclear infiltrate. We suggest that examination for a TMD be undertaken in neonates with a vesiculopustular eruption and leukemic white blood cell counts.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Inc</pub><pmid>15461760</pmid><doi>10.1111/j.0736-8046.2004.21505.x</doi><tpages>4</tpages></addata></record> |
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| ispartof | Pediatric dermatology, 2004-09, Vol.21 (5), p.551-554 |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Biological and medical sciences Dermatology Diagnosis, Differential Down Syndrome Female Humans Infant, Newborn Leukocyte Count Medical sciences Myeloproliferative Disorders - blood Myeloproliferative Disorders - complications Myeloproliferative Disorders - diagnosis Phenotype Skin Diseases, Vesiculobullous - etiology Skin Diseases, Vesiculobullous - pathology |
| title | Transient Myeloproliferative Disorder Causing a Vesiculopustular Eruption in a Phenotypically Normal Neonate |
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