Exchangeability of Mammalian DNA Ligases between Base Excision Repair Pathways

In mammalian cells, DNA ligase IIIα and DNA ligase I participate in the short- and long-patch base excision repair pathways, respectively. Using an in vitro repair assay employing DNA ligase-depleted cell extracts and DNA substrates containing a single lesion repaired either through short-patch (reg...

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Veröffentlicht in:	Biochemistry (Easton) 2004-10, Vol.43 (40), p.12924-12930
Hauptverfasser:	Sleeth, Kate M, Robson, Robert L, Dianov, Grigory L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cell Line CHO Cells Cricetinae DNA - genetics DNA - metabolism DNA Damage DNA Ligase ATP DNA Ligases - deficiency DNA Ligases - metabolism DNA Repair DNA-Binding Proteins - metabolism Humans Molecular Sequence Data Poly-ADP-Ribose Binding Proteins Time Factors X-ray Repair Cross Complementing Protein 1 Xenopus Proteins
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