Nonlinear Mixed Effects Model Analysis of the Pharmacokinetics of Metoprolol in Routinely Treated Japanese Patients

This study was performed to estimate the mean pharmacokinetic parameters of routinely administered metoprolol in middle-aged and elderly Japanese patients. Whole blood concentration data (65 samples) at steady-state following repetitive administration to 34 patients were analyzed using a nonlinear m...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2004, Vol.27(10), pp.1642-1648
Hauptverfasser:	Taguchi, Masato, Nozawa, Takashi, Mizumaki, Kouichi, Inoue, Hiroshi, Tahara, Katsutoshi, Takesono, Chihiro, Hashimoto, Yukiya
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Aged, 80 and over aging Aryl Hydrocarbon Hydroxylases - genetics Aryl Hydrocarbon Hydroxylases - metabolism Asian Continental Ancestry Group Cytochrome P-450 CYP2C19 Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP2D6 - metabolism Female Genotype Heart Failure - metabolism Humans Hypertension - metabolism Japanese patient Male Metabolic Clearance Rate metoprolol Metoprolol - blood Metoprolol - pharmacokinetics Middle Aged Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism Nonlinear Dynamics nonlinear mixed effects model (NONMEM) pharmacokinetics Polymorphism, Genetic Sex Factors whole blood concentration
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