Genetically determined resistance to collagenase action augments interstitial collagen accumulation in atherosclerotic plaques

We hypothesized that collagenolytic activity produced by activated macrophages contributes to collagen loss and the subsequent instability of atheromatous lesions, a common trigger of acute coronary syndromes. However, no direct in vivo evidence links collagenases with the regulation of collagen con...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2004-10, Vol.110 (14), p.1953-1959
Hauptverfasser:	FUKUMOTO, Yoshihiro, DEGUCHI, Jun-O, KRANE, Stephen M, AIKAWA, Masanori, LIBBY, Peter, RABKIN-AIKAWA, Elena, SAKATA, Yasuhiko, CHIN, Michael T, HILL, Christopher C, LAWLER, Patrick R, VARO, Nerea, SCHOEN, Frederick J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Apolipoproteins E - deficiency Apolipoproteins E - genetics Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular system Cell Count Cell Death Cell Movement Collagen Type I - genetics Collagen Type I - metabolism Collagenases - metabolism Coronary Artery Disease - enzymology Coronary Artery Disease - genetics Coronary Artery Disease - pathology Crosses, Genetic Diet, Atherogenic Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Macrophages - enzymology Macrophages, Peritoneal - enzymology Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Miscellaneous Muscle, Smooth, Vascular - pathology Pharmacology. Drug treatments Substrate Specificity - genetics Tunica Intima - pathology
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