Protein Kinase C Alpha Expression in Breast and Ovarian Cancer

In recent years research has focused on the development of specific, targeted drugs to treat cancer. One approach has been to block intracellular signaling proteins, such as protein kinase C alpha (PKC-α). To help support the rationale for clinical studies of a PKC-α-targeted therapy in breast and o...

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Veröffentlicht in:	Oncology 2004-01, Vol.67 (1), p.1-10
Hauptverfasser:	Lahn, Michael, Köhler, Gabriele, Sundell, Karen, Su, Chen, Li, Shuyu, Paterson, Blake M., Bumol, Thomas F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - therapeutic use Biological and medical sciences Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - epidemiology Breast Neoplasms - genetics Drug Resistance, Multiple Drug Resistance, Neoplasm Enzyme Inhibitors - therapeutic use Estrogens Female Female genital diseases Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Oligonucleotides, Antisense - therapeutic use Oncology Ovarian cancer Ovarian Neoplasms - enzymology Ovarian Neoplasms - epidemiology Ovarian Neoplasms - genetics Phosphorothioate Oligonucleotides Protein Kinase C - antagonists & inhibitors Protein Kinase C - genetics Protein Kinase C - metabolism Protein Kinase C-alpha Proteins Receptors, Estrogen - metabolism Review Tumors
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