Influence of rheumatoid arthritis in the enantioselective disposition of fenoprofen

To investigate the influence of rheumatoid arthritis on the stereoselective disposition of fenoprofen administered as a racemic mixture, eight patients with rheumatoid arthritis receiving calcium rac‐fenoprofen (200 mg/8 h) and 7 healthy volunteers given single oral dose (600 mg) were investigated....

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Veröffentlicht in:	Chirality (New York, N.Y.) N.Y.), 2004, Vol.16 (9), p.602-608
Hauptverfasser:	Barissa, Giuliano Rodrigo, Poggi, Josiane Cristófani, Donadi, Eduardo Antônio, dos Reis, Marina Lemos, Lanchote, Vera Lucia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Area Under Curve Arthritis, Rheumatoid - metabolism enantiomers Female fenoprofen Fenoprofen - chemistry Fenoprofen - pharmacokinetics Glucuronides - urine Half-Life Humans Male metabolism Middle Aged pharmacokinetics rheumatoid arthritis Serum Albumin - metabolism Stereoisomerism
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