Acute social defeat reduces neurotrophin expression in brain cortical and subcortical areas in mice
Acute social defeat in mice activates the hypothalamic–pituitary–adrenal axis (HPA) and induces long-term behavioral changes, including exaggerated fear responses and inhibition of territorial behavior. Stress-induced hormonal and neurotransmitter release may contribute to disruption of expression o...
Gespeichert in:
| Veröffentlicht in: | Brain research 2004-10, Vol.1025 (1), p.10-20 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 20 |
|---|---|
| container_issue | 1 |
| container_start_page | 10 |
| container_title | Brain research |
| container_volume | 1025 |
| creator | Pizarro, José M. Lumley, Lucille A. Medina, Wilma Robison, Christopher L. Chang, Wenling E. Alagappan, Arun Bah, Mariama J. Dawood, Mustansir Y. Shah, Jinesh D. Mark, Brian Kendall, Nadia Smith, Mark A. Saviolakis, George A. Meyerhoff, James L. |
| description | Acute social defeat in mice activates the hypothalamic–pituitary–adrenal axis (HPA) and induces long-term behavioral changes, including exaggerated fear responses and inhibition of territorial behavior. Stress-induced hormonal and neurotransmitter release may contribute to disruption of expression of genes important for cell survival, neuronal plasticity, and neuronal remodeling. Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor associated with structural cellular changes that occur during nervous system development and contributes to neural plasticity in the adult brain. In rats, acute (1–2 h) restraint stress transiently reduces BDNF mRNA expression in the hippocampus, a region important in the memory and in HPA regulation; restraint stress also decreases BDNF expression in the basolateral amygdala (BLA), a region important for fear consolidation and emotional memory. We hypothesized that a brief (10 min) exposure to intense social stress, a more naturalistic stressor than restraint stress, would also reduce BDNF mRNA in the hippocampus and BLA of mice. In the present study, we examined the time course of expression of BDNF mRNA expression in the hippocampus and amygdala, as well as other subcortical and cortical brain regions, following acute social stress. In situ hybridization analysis for BDNF mRNA expression showed that there was a significant decrease in BDNF mRNA expression in all regions studied in mice 24 h after social defeat when compared to control (naïve) mice (
P |
| doi_str_mv | 10.1016/j.brainres.2004.06.085 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66933326</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006899304010546</els_id><sourcerecordid>66933326</sourcerecordid><originalsourceid>FETCH-LOGICAL-c425t-8e63e71adf226d0d6323dc4656bc25c797771445a7ea937c52a438abe0afb96a3</originalsourceid><addsrcrecordid>eNqFkU9v1DAUxC0EotvCV6hygVuC_8WOb1RVoUiVuMDZcp5fhFe78eKXIPj2eNlFe-zJGuk3HnuGsVvBO8GF-bDtxhLSXJA6ybnuuOn40L9gGzFY2Rqp-Uu24ZybdnBOXbFrom2VSjn-ml2JXhttldswuIN1wYYypLBrIk4YlqZgXAGpmXEteSn58CPNDf4-1DRKeW6q-pfeQC5LgmoMc2xoHS-6YKAjt0-Ab9irKewI357PG_b908O3-8f26evnL_d3Ty1o2S_tgEahFSFOUprIo1FSRdCmNyPIHqyz1gqt-2AxOGWhl0GrIYzIwzQ6E9QNe3-691DyzxVp8ftEgLtdmDGv5I1xSilpngWFHQbupK2gOYFQMlHByR9K2ofyxwvujzv4rf-_gz_u4LnxdYdqvD0nrOMe48V2Lr4C785AoFrYVMIMiS6cEf1Qv1u5jycOa3G_EhZPkHAGjKkgLD7m9Nxb_gLjMKsA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17880927</pqid></control><display><type>article</type><title>Acute social defeat reduces neurotrophin expression in brain cortical and subcortical areas in mice</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Pizarro, José M. ; Lumley, Lucille A. ; Medina, Wilma ; Robison, Christopher L. ; Chang, Wenling E. ; Alagappan, Arun ; Bah, Mariama J. ; Dawood, Mustansir Y. ; Shah, Jinesh D. ; Mark, Brian ; Kendall, Nadia ; Smith, Mark A. ; Saviolakis, George A. ; Meyerhoff, James L.</creator><creatorcontrib>Pizarro, José M. ; Lumley, Lucille A. ; Medina, Wilma ; Robison, Christopher L. ; Chang, Wenling E. ; Alagappan, Arun ; Bah, Mariama J. ; Dawood, Mustansir Y. ; Shah, Jinesh D. ; Mark, Brian ; Kendall, Nadia ; Smith, Mark A. ; Saviolakis, George A. ; Meyerhoff, James L.</creatorcontrib><description>Acute social defeat in mice activates the hypothalamic–pituitary–adrenal axis (HPA) and induces long-term behavioral changes, including exaggerated fear responses and inhibition of territorial behavior. Stress-induced hormonal and neurotransmitter release may contribute to disruption of expression of genes important for cell survival, neuronal plasticity, and neuronal remodeling. Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor associated with structural cellular changes that occur during nervous system development and contributes to neural plasticity in the adult brain. In rats, acute (1–2 h) restraint stress transiently reduces BDNF mRNA expression in the hippocampus, a region important in the memory and in HPA regulation; restraint stress also decreases BDNF expression in the basolateral amygdala (BLA), a region important for fear consolidation and emotional memory. We hypothesized that a brief (10 min) exposure to intense social stress, a more naturalistic stressor than restraint stress, would also reduce BDNF mRNA in the hippocampus and BLA of mice. In the present study, we examined the time course of expression of BDNF mRNA expression in the hippocampus and amygdala, as well as other subcortical and cortical brain regions, following acute social stress. In situ hybridization analysis for BDNF mRNA expression showed that there was a significant decrease in BDNF mRNA expression in all regions studied in mice 24 h after social defeat when compared to control (naïve) mice (
P<0.05). These findings support our hypothesis that BDNF mRNA levels are reduced by social stress, and may have implications for brain plasticity and behavioral changes following social stress.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2004.06.085</identifier><identifier>PMID: 15464739</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Anatomical correlates of behavior ; Animals ; BDNF mRNA ; Behavioral psychophysiology ; Biological and medical sciences ; Cerebral Cortex - metabolism ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation - physiology ; Hippocampus ; Male ; Mice ; Mice, Inbred C57BL ; Mouse ; Nerve Growth Factors - biosynthesis ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Social Behavior ; Social stress ; Stress, Psychological - metabolism</subject><ispartof>Brain research, 2004-10, Vol.1025 (1), p.10-20</ispartof><rights>2004</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-8e63e71adf226d0d6323dc4656bc25c797771445a7ea937c52a438abe0afb96a3</citedby><cites>FETCH-LOGICAL-c425t-8e63e71adf226d0d6323dc4656bc25c797771445a7ea937c52a438abe0afb96a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.brainres.2004.06.085$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16158771$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15464739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pizarro, José M.</creatorcontrib><creatorcontrib>Lumley, Lucille A.</creatorcontrib><creatorcontrib>Medina, Wilma</creatorcontrib><creatorcontrib>Robison, Christopher L.</creatorcontrib><creatorcontrib>Chang, Wenling E.</creatorcontrib><creatorcontrib>Alagappan, Arun</creatorcontrib><creatorcontrib>Bah, Mariama J.</creatorcontrib><creatorcontrib>Dawood, Mustansir Y.</creatorcontrib><creatorcontrib>Shah, Jinesh D.</creatorcontrib><creatorcontrib>Mark, Brian</creatorcontrib><creatorcontrib>Kendall, Nadia</creatorcontrib><creatorcontrib>Smith, Mark A.</creatorcontrib><creatorcontrib>Saviolakis, George A.</creatorcontrib><creatorcontrib>Meyerhoff, James L.</creatorcontrib><title>Acute social defeat reduces neurotrophin expression in brain cortical and subcortical areas in mice</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Acute social defeat in mice activates the hypothalamic–pituitary–adrenal axis (HPA) and induces long-term behavioral changes, including exaggerated fear responses and inhibition of territorial behavior. Stress-induced hormonal and neurotransmitter release may contribute to disruption of expression of genes important for cell survival, neuronal plasticity, and neuronal remodeling. Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor associated with structural cellular changes that occur during nervous system development and contributes to neural plasticity in the adult brain. In rats, acute (1–2 h) restraint stress transiently reduces BDNF mRNA expression in the hippocampus, a region important in the memory and in HPA regulation; restraint stress also decreases BDNF expression in the basolateral amygdala (BLA), a region important for fear consolidation and emotional memory. We hypothesized that a brief (10 min) exposure to intense social stress, a more naturalistic stressor than restraint stress, would also reduce BDNF mRNA in the hippocampus and BLA of mice. In the present study, we examined the time course of expression of BDNF mRNA expression in the hippocampus and amygdala, as well as other subcortical and cortical brain regions, following acute social stress. In situ hybridization analysis for BDNF mRNA expression showed that there was a significant decrease in BDNF mRNA expression in all regions studied in mice 24 h after social defeat when compared to control (naïve) mice (
P<0.05). These findings support our hypothesis that BDNF mRNA levels are reduced by social stress, and may have implications for brain plasticity and behavioral changes following social stress.</description><subject>Anatomical correlates of behavior</subject><subject>Animals</subject><subject>BDNF mRNA</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Cerebral Cortex - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation - physiology</subject><subject>Hippocampus</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mouse</subject><subject>Nerve Growth Factors - biosynthesis</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Social Behavior</subject><subject>Social stress</subject><subject>Stress, Psychological - metabolism</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAUxC0EotvCV6hygVuC_8WOb1RVoUiVuMDZcp5fhFe78eKXIPj2eNlFe-zJGuk3HnuGsVvBO8GF-bDtxhLSXJA6ybnuuOn40L9gGzFY2Rqp-Uu24ZybdnBOXbFrom2VSjn-ml2JXhttldswuIN1wYYypLBrIk4YlqZgXAGpmXEteSn58CPNDf4-1DRKeW6q-pfeQC5LgmoMc2xoHS-6YKAjt0-Ab9irKewI357PG_b908O3-8f26evnL_d3Ty1o2S_tgEahFSFOUprIo1FSRdCmNyPIHqyz1gqt-2AxOGWhl0GrIYzIwzQ6E9QNe3-691DyzxVp8ftEgLtdmDGv5I1xSilpngWFHQbupK2gOYFQMlHByR9K2ofyxwvujzv4rf-_gz_u4LnxdYdqvD0nrOMe48V2Lr4C785AoFrYVMIMiS6cEf1Qv1u5jycOa3G_EhZPkHAGjKkgLD7m9Nxb_gLjMKsA</recordid><startdate>20041029</startdate><enddate>20041029</enddate><creator>Pizarro, José M.</creator><creator>Lumley, Lucille A.</creator><creator>Medina, Wilma</creator><creator>Robison, Christopher L.</creator><creator>Chang, Wenling E.</creator><creator>Alagappan, Arun</creator><creator>Bah, Mariama J.</creator><creator>Dawood, Mustansir Y.</creator><creator>Shah, Jinesh D.</creator><creator>Mark, Brian</creator><creator>Kendall, Nadia</creator><creator>Smith, Mark A.</creator><creator>Saviolakis, George A.</creator><creator>Meyerhoff, James L.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20041029</creationdate><title>Acute social defeat reduces neurotrophin expression in brain cortical and subcortical areas in mice</title><author>Pizarro, José M. ; Lumley, Lucille A. ; Medina, Wilma ; Robison, Christopher L. ; Chang, Wenling E. ; Alagappan, Arun ; Bah, Mariama J. ; Dawood, Mustansir Y. ; Shah, Jinesh D. ; Mark, Brian ; Kendall, Nadia ; Smith, Mark A. ; Saviolakis, George A. ; Meyerhoff, James L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-8e63e71adf226d0d6323dc4656bc25c797771445a7ea937c52a438abe0afb96a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Anatomical correlates of behavior</topic><topic>Animals</topic><topic>BDNF mRNA</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Cerebral Cortex - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation - physiology</topic><topic>Hippocampus</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mouse</topic><topic>Nerve Growth Factors - biosynthesis</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Social Behavior</topic><topic>Social stress</topic><topic>Stress, Psychological - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pizarro, José M.</creatorcontrib><creatorcontrib>Lumley, Lucille A.</creatorcontrib><creatorcontrib>Medina, Wilma</creatorcontrib><creatorcontrib>Robison, Christopher L.</creatorcontrib><creatorcontrib>Chang, Wenling E.</creatorcontrib><creatorcontrib>Alagappan, Arun</creatorcontrib><creatorcontrib>Bah, Mariama J.</creatorcontrib><creatorcontrib>Dawood, Mustansir Y.</creatorcontrib><creatorcontrib>Shah, Jinesh D.</creatorcontrib><creatorcontrib>Mark, Brian</creatorcontrib><creatorcontrib>Kendall, Nadia</creatorcontrib><creatorcontrib>Smith, Mark A.</creatorcontrib><creatorcontrib>Saviolakis, George A.</creatorcontrib><creatorcontrib>Meyerhoff, James L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pizarro, José M.</au><au>Lumley, Lucille A.</au><au>Medina, Wilma</au><au>Robison, Christopher L.</au><au>Chang, Wenling E.</au><au>Alagappan, Arun</au><au>Bah, Mariama J.</au><au>Dawood, Mustansir Y.</au><au>Shah, Jinesh D.</au><au>Mark, Brian</au><au>Kendall, Nadia</au><au>Smith, Mark A.</au><au>Saviolakis, George A.</au><au>Meyerhoff, James L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute social defeat reduces neurotrophin expression in brain cortical and subcortical areas in mice</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2004-10-29</date><risdate>2004</risdate><volume>1025</volume><issue>1</issue><spage>10</spage><epage>20</epage><pages>10-20</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Acute social defeat in mice activates the hypothalamic–pituitary–adrenal axis (HPA) and induces long-term behavioral changes, including exaggerated fear responses and inhibition of territorial behavior. Stress-induced hormonal and neurotransmitter release may contribute to disruption of expression of genes important for cell survival, neuronal plasticity, and neuronal remodeling. Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor associated with structural cellular changes that occur during nervous system development and contributes to neural plasticity in the adult brain. In rats, acute (1–2 h) restraint stress transiently reduces BDNF mRNA expression in the hippocampus, a region important in the memory and in HPA regulation; restraint stress also decreases BDNF expression in the basolateral amygdala (BLA), a region important for fear consolidation and emotional memory. We hypothesized that a brief (10 min) exposure to intense social stress, a more naturalistic stressor than restraint stress, would also reduce BDNF mRNA in the hippocampus and BLA of mice. In the present study, we examined the time course of expression of BDNF mRNA expression in the hippocampus and amygdala, as well as other subcortical and cortical brain regions, following acute social stress. In situ hybridization analysis for BDNF mRNA expression showed that there was a significant decrease in BDNF mRNA expression in all regions studied in mice 24 h after social defeat when compared to control (naïve) mice (
P<0.05). These findings support our hypothesis that BDNF mRNA levels are reduced by social stress, and may have implications for brain plasticity and behavioral changes following social stress.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>15464739</pmid><doi>10.1016/j.brainres.2004.06.085</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 2004-10, Vol.1025 (1), p.10-20 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66933326 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Anatomical correlates of behavior Animals BDNF mRNA Behavioral psychophysiology Biological and medical sciences Cerebral Cortex - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation - physiology Hippocampus Male Mice Mice, Inbred C57BL Mouse Nerve Growth Factors - biosynthesis Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Social Behavior Social stress Stress, Psychological - metabolism |
| title | Acute social defeat reduces neurotrophin expression in brain cortical and subcortical areas in mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T08%3A44%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acute%20social%20defeat%20reduces%20neurotrophin%20expression%20in%20brain%20cortical%20and%20subcortical%20areas%20in%20mice&rft.jtitle=Brain%20research&rft.au=Pizarro,%20Jos%C3%A9%20M.&rft.date=2004-10-29&rft.volume=1025&rft.issue=1&rft.spage=10&rft.epage=20&rft.pages=10-20&rft.issn=0006-8993&rft.eissn=1872-6240&rft.coden=BRREAP&rft_id=info:doi/10.1016/j.brainres.2004.06.085&rft_dat=%3Cproquest_cross%3E66933326%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17880927&rft_id=info:pmid/15464739&rft_els_id=S0006899304010546&rfr_iscdi=true |