Metabolic Syndrome and the Risk of Prostate Cancer in Finnish Men: A Population-Based Study
Objective: Individual components of metabolic syndrome have been linked to an increased risk for prostate cancers. We hypothesized that metabolic syndrome itself could confer an increased risk for incident prostate cancer. Methods: The participants were a population-based sample of 1,880 men from ea...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2004-10, Vol.13 (10), p.1646-1650 |
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| creator | LAUKKANEN, Jari A LAAKSONEN, David E NISKANEN, Leo PUKKALA, Eero HAKKARAINEN, Anna SALONEN, Jukka T |
| description | Objective: Individual components of metabolic syndrome have been linked to an increased risk for prostate cancers. We hypothesized
that metabolic syndrome itself could confer an increased risk for incident prostate cancer. Methods: The participants were
a population-based sample of 1,880 men from eastern Finland without history of cancer or diabetes mellitus at baseline. Results:
The metabolic syndrome (WHO criteria) was present in 357 (19%) of subjects. During an average follow-up of 13 years, a total
of 183 cancers occurred, of which 56 were due to prostate cancer. The metabolic syndrome at baseline was related to a 1.9-fold
(95% confidence interval, 1.1-3.5) risk of prostate cancer after adjustment for age, alcohol consumption, physical fitness,
and energy, fat, fiber, calcium, vitamin E, and α-linolenic acid intake. The association between metabolic syndrome and risk
of prostate cancer was stronger among overweight and obese men with a body mass index ≥27 kg/m 2 (adjusted relative risk, 3.0; 95% confidence interval, 1.2-7.3) than in lighter men (relative risk, 1.8; 95% confidence interval,
0.7-4.7). Conclusions: Middle-aged men with the metabolic syndrome were more likely to develop prostate cancer in this prospective
population-based study. This finding suggests that efforts to curb the epidemic of overweight and sedentary lifestyle and
the accompanying metabolic syndrome may decrease the risk for prostate cancer. |
| doi_str_mv | 10.1158/1055-9965.1646.13.10 |
| format | Article |
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that metabolic syndrome itself could confer an increased risk for incident prostate cancer. Methods: The participants were
a population-based sample of 1,880 men from eastern Finland without history of cancer or diabetes mellitus at baseline. Results:
The metabolic syndrome (WHO criteria) was present in 357 (19%) of subjects. During an average follow-up of 13 years, a total
of 183 cancers occurred, of which 56 were due to prostate cancer. The metabolic syndrome at baseline was related to a 1.9-fold
(95% confidence interval, 1.1-3.5) risk of prostate cancer after adjustment for age, alcohol consumption, physical fitness,
and energy, fat, fiber, calcium, vitamin E, and α-linolenic acid intake. The association between metabolic syndrome and risk
of prostate cancer was stronger among overweight and obese men with a body mass index ≥27 kg/m 2 (adjusted relative risk, 3.0; 95% confidence interval, 1.2-7.3) than in lighter men (relative risk, 1.8; 95% confidence interval,
0.7-4.7). Conclusions: Middle-aged men with the metabolic syndrome were more likely to develop prostate cancer in this prospective
population-based study. This finding suggests that efforts to curb the epidemic of overweight and sedentary lifestyle and
the accompanying metabolic syndrome may decrease the risk for prostate cancer.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.1646.13.10</identifier><identifier>PMID: 15466982</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Biological and medical sciences ; Finland - epidemiology ; Humans ; Incidence ; Life Style ; Male ; Medical sciences ; Metabolic Syndrome - complications ; Middle Aged ; Nephrology. Urinary tract diseases ; Obesity ; Prospective Studies ; Prostatic Neoplasms - epidemiology ; Prostatic Neoplasms - etiology ; Risk Factors ; Tumors ; Tumors of the urinary system ; Urinary tract. Prostate gland</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2004-10, Vol.13 (10), p.1646-1650</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-87a65000b6fe1e39300009f98fb67dc80c5120d1a5182fdfed9bfe669582e1023</citedby><cites>FETCH-LOGICAL-c479t-87a65000b6fe1e39300009f98fb67dc80c5120d1a5182fdfed9bfe669582e1023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16174576$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15466982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LAUKKANEN, Jari A</creatorcontrib><creatorcontrib>LAAKSONEN, David E</creatorcontrib><creatorcontrib>NISKANEN, Leo</creatorcontrib><creatorcontrib>PUKKALA, Eero</creatorcontrib><creatorcontrib>HAKKARAINEN, Anna</creatorcontrib><creatorcontrib>SALONEN, Jukka T</creatorcontrib><title>Metabolic Syndrome and the Risk of Prostate Cancer in Finnish Men: A Population-Based Study</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Objective: Individual components of metabolic syndrome have been linked to an increased risk for prostate cancers. We hypothesized
that metabolic syndrome itself could confer an increased risk for incident prostate cancer. Methods: The participants were
a population-based sample of 1,880 men from eastern Finland without history of cancer or diabetes mellitus at baseline. Results:
The metabolic syndrome (WHO criteria) was present in 357 (19%) of subjects. During an average follow-up of 13 years, a total
of 183 cancers occurred, of which 56 were due to prostate cancer. The metabolic syndrome at baseline was related to a 1.9-fold
(95% confidence interval, 1.1-3.5) risk of prostate cancer after adjustment for age, alcohol consumption, physical fitness,
and energy, fat, fiber, calcium, vitamin E, and α-linolenic acid intake. The association between metabolic syndrome and risk
of prostate cancer was stronger among overweight and obese men with a body mass index ≥27 kg/m 2 (adjusted relative risk, 3.0; 95% confidence interval, 1.2-7.3) than in lighter men (relative risk, 1.8; 95% confidence interval,
0.7-4.7). Conclusions: Middle-aged men with the metabolic syndrome were more likely to develop prostate cancer in this prospective
population-based study. This finding suggests that efforts to curb the epidemic of overweight and sedentary lifestyle and
the accompanying metabolic syndrome may decrease the risk for prostate cancer.</description><subject>Biological and medical sciences</subject><subject>Finland - epidemiology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Life Style</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic Syndrome - complications</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Obesity</subject><subject>Prospective Studies</subject><subject>Prostatic Neoplasms - epidemiology</subject><subject>Prostatic Neoplasms - etiology</subject><subject>Risk Factors</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtv1DAQgC0Eog_4Bwj5AhKHLHYcv7iVFQWkVlQUThwsxx4TQ9bZ2onQ_vt6u4t6mtHom9eH0CtKVpRy9Z4SzhutBV9R0YkVZStKnqBTyplqpOT8ac3_IyforJQ_hBCpOX-OTijvhNCqPUW_rmG2_TRGh293yedpA9gmj-cB8PdY_uIp4Js8ldnOgNc2Ocg4JnwZU4plwNeQPuALfDNtl9HOcUrNR1vA49t58bsX6FmwY4GXx3iOfl5--rH-0lx9-_x1fXHVuE7quVHSCl5v60UACkyzmhMdtAq9kN4p4jhtiaeWU9UGH8DrPkC9n6sWKGnZOXp7mLvN090CZTabWByMo00wLcVUlLWSqQp2B9DVj0qGYLY5bmzeGUrMXqrZGzN7Y2Yv1VBWK7Xt9XH-0m_APzYdLVbgzRGwxdkx5OoplkdOUNlxKSr37sAN8ffwL2Yw7sFohgI2u-Gw72E1uwf6o4we</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>LAUKKANEN, Jari A</creator><creator>LAAKSONEN, David E</creator><creator>NISKANEN, Leo</creator><creator>PUKKALA, Eero</creator><creator>HAKKARAINEN, Anna</creator><creator>SALONEN, Jukka T</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041001</creationdate><title>Metabolic Syndrome and the Risk of Prostate Cancer in Finnish Men: A Population-Based Study</title><author>LAUKKANEN, Jari A ; LAAKSONEN, David E ; NISKANEN, Leo ; PUKKALA, Eero ; HAKKARAINEN, Anna ; SALONEN, Jukka T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-87a65000b6fe1e39300009f98fb67dc80c5120d1a5182fdfed9bfe669582e1023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Biological and medical sciences</topic><topic>Finland - epidemiology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Life Style</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic Syndrome - complications</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Obesity</topic><topic>Prospective Studies</topic><topic>Prostatic Neoplasms - epidemiology</topic><topic>Prostatic Neoplasms - etiology</topic><topic>Risk Factors</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LAUKKANEN, Jari A</creatorcontrib><creatorcontrib>LAAKSONEN, David E</creatorcontrib><creatorcontrib>NISKANEN, Leo</creatorcontrib><creatorcontrib>PUKKALA, Eero</creatorcontrib><creatorcontrib>HAKKARAINEN, Anna</creatorcontrib><creatorcontrib>SALONEN, Jukka T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LAUKKANEN, Jari A</au><au>LAAKSONEN, David E</au><au>NISKANEN, Leo</au><au>PUKKALA, Eero</au><au>HAKKARAINEN, Anna</au><au>SALONEN, Jukka T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic Syndrome and the Risk of Prostate Cancer in Finnish Men: A Population-Based Study</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>13</volume><issue>10</issue><spage>1646</spage><epage>1650</epage><pages>1646-1650</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>Objective: Individual components of metabolic syndrome have been linked to an increased risk for prostate cancers. We hypothesized
that metabolic syndrome itself could confer an increased risk for incident prostate cancer. Methods: The participants were
a population-based sample of 1,880 men from eastern Finland without history of cancer or diabetes mellitus at baseline. Results:
The metabolic syndrome (WHO criteria) was present in 357 (19%) of subjects. During an average follow-up of 13 years, a total
of 183 cancers occurred, of which 56 were due to prostate cancer. The metabolic syndrome at baseline was related to a 1.9-fold
(95% confidence interval, 1.1-3.5) risk of prostate cancer after adjustment for age, alcohol consumption, physical fitness,
and energy, fat, fiber, calcium, vitamin E, and α-linolenic acid intake. The association between metabolic syndrome and risk
of prostate cancer was stronger among overweight and obese men with a body mass index ≥27 kg/m 2 (adjusted relative risk, 3.0; 95% confidence interval, 1.2-7.3) than in lighter men (relative risk, 1.8; 95% confidence interval,
0.7-4.7). Conclusions: Middle-aged men with the metabolic syndrome were more likely to develop prostate cancer in this prospective
population-based study. This finding suggests that efforts to curb the epidemic of overweight and sedentary lifestyle and
the accompanying metabolic syndrome may decrease the risk for prostate cancer.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>15466982</pmid><doi>10.1158/1055-9965.1646.13.10</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biological and medical sciences Finland - epidemiology Humans Incidence Life Style Male Medical sciences Metabolic Syndrome - complications Middle Aged Nephrology. Urinary tract diseases Obesity Prospective Studies Prostatic Neoplasms - epidemiology Prostatic Neoplasms - etiology Risk Factors Tumors Tumors of the urinary system Urinary tract. Prostate gland |
| title | Metabolic Syndrome and the Risk of Prostate Cancer in Finnish Men: A Population-Based Study |
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