Integrin signalling during tumour progression

Key Points Dysregulated combined signalling between integrins and receptor tyrosine kinases (RTKs) promotes the disruption of adherens junctions at the onset of carcinoma invasion. Src-family kinases (SFKs) induce the expression of SNAIL/SLUG transcription factors, which repress transcription of the...

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Veröffentlicht in:	Nature reviews. Molecular cell biology 2004-10, Vol.5 (10), p.816-826
Hauptverfasser:	Guo, Wenjun, Giancotti, Filippo G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Biochemistry Biomedical and Life Sciences Blood vessels Cancer Cancer Research Cell Biology Cell Movement - physiology Cell Survival Developmental Biology Extracellular matrix Extracellular Matrix - metabolism Integrins - genetics Integrins - metabolism Kinases Life Sciences Metastasis Microenvironments Models, Biological Mutation Neoplasm Metastasis Neoplasms - metabolism Neoplasms - pathology Neovascularization, Pathologic Proteins Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism review-article Signal Transduction - physiology Stem Cells Tumors
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