Hyperexcitable blink reflex preceding the diagnosis of neuroblastoma
The diagnosis of neuroblastoma is sometimes preceded by development of a paraneoplastic syndrome, most commonly opsoclonus-myoclonus-ataxia (OMA). The authors describe a patient who developed a hyperexcitable blink reflex, without symptoms of OMA, prior to his oncologic diagnosis. The authors believ...
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| Veröffentlicht in: | Journal of pediatric hematology/oncology 2004-10, Vol.26 (10), p.665-667 |
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| container_end_page | 667 |
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| container_issue | 10 |
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| container_title | Journal of pediatric hematology/oncology |
| container_volume | 26 |
| creator | Ramadan, Mohamed Whalen, Bonny De Santes, Kenneth |
| description | The diagnosis of neuroblastoma is sometimes preceded by development of a paraneoplastic syndrome, most commonly opsoclonus-myoclonus-ataxia (OMA). The authors describe a patient who developed a hyperexcitable blink reflex, without symptoms of OMA, prior to his oncologic diagnosis. The authors believe this may represent a distinct paraneoplastic process caused by increased dopaminergic stimulation of the blink reflex and suggest that children manifesting an unexplained hyperexcitable blink reflex should be screened for occult neuroblastoma. |
| doi_str_mv | 10.1097/01.mph.0000140657.96085.65 |
| format | Article |
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The authors describe a patient who developed a hyperexcitable blink reflex, without symptoms of OMA, prior to his oncologic diagnosis. The authors believe this may represent a distinct paraneoplastic process caused by increased dopaminergic stimulation of the blink reflex and suggest that children manifesting an unexplained hyperexcitable blink reflex should be screened for occult neuroblastoma.</description><identifier>ISSN: 1077-4114</identifier><identifier>EISSN: 1536-3678</identifier><identifier>DOI: 10.1097/01.mph.0000140657.96085.65</identifier><identifier>PMID: 15454839</identifier><language>eng</language><publisher>United States</publisher><subject>Abdominal Injuries - complications ; Adrenal Gland Neoplasms - complications ; Adrenal Gland Neoplasms - diagnosis ; Adrenal Gland Neoplasms - diagnostic imaging ; Adrenal Gland Neoplasms - secretion ; Adrenal Gland Neoplasms - surgery ; Adrenal Gland Neoplasms - urine ; Blinking - physiology ; Catecholamines - secretion ; Catecholamines - urine ; Child, Preschool ; Dopamine - physiology ; Ganglioneuroblastoma - complications ; Ganglioneuroblastoma - diagnosis ; Ganglioneuroblastoma - diagnostic imaging ; Ganglioneuroblastoma - secretion ; Ganglioneuroblastoma - surgery ; Ganglioneuroblastoma - urine ; Humans ; Incidental Findings ; Male ; Paraneoplastic Syndromes - diagnosis ; Paraneoplastic Syndromes - etiology ; Paraneoplastic Syndromes - physiopathology ; Reflex, Abnormal - physiology ; Remission Induction ; Tomography, X-Ray Computed</subject><ispartof>Journal of pediatric hematology/oncology, 2004-10, Vol.26 (10), p.665-667</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-62f59750f343a4c0995824dc9cdff445264007b389e4c5c6fb3360d76a5797d03</citedby><cites>FETCH-LOGICAL-c348t-62f59750f343a4c0995824dc9cdff445264007b389e4c5c6fb3360d76a5797d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15454839$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramadan, Mohamed</creatorcontrib><creatorcontrib>Whalen, Bonny</creatorcontrib><creatorcontrib>De Santes, Kenneth</creatorcontrib><title>Hyperexcitable blink reflex preceding the diagnosis of neuroblastoma</title><title>Journal of pediatric hematology/oncology</title><addtitle>J Pediatr Hematol Oncol</addtitle><description>The diagnosis of neuroblastoma is sometimes preceded by development of a paraneoplastic syndrome, most commonly opsoclonus-myoclonus-ataxia (OMA). The authors describe a patient who developed a hyperexcitable blink reflex, without symptoms of OMA, prior to his oncologic diagnosis. The authors believe this may represent a distinct paraneoplastic process caused by increased dopaminergic stimulation of the blink reflex and suggest that children manifesting an unexplained hyperexcitable blink reflex should be screened for occult neuroblastoma.</description><subject>Abdominal Injuries - complications</subject><subject>Adrenal Gland Neoplasms - complications</subject><subject>Adrenal Gland Neoplasms - diagnosis</subject><subject>Adrenal Gland Neoplasms - diagnostic imaging</subject><subject>Adrenal Gland Neoplasms - secretion</subject><subject>Adrenal Gland Neoplasms - surgery</subject><subject>Adrenal Gland Neoplasms - urine</subject><subject>Blinking - physiology</subject><subject>Catecholamines - secretion</subject><subject>Catecholamines - urine</subject><subject>Child, Preschool</subject><subject>Dopamine - physiology</subject><subject>Ganglioneuroblastoma - complications</subject><subject>Ganglioneuroblastoma - diagnosis</subject><subject>Ganglioneuroblastoma - diagnostic imaging</subject><subject>Ganglioneuroblastoma - secretion</subject><subject>Ganglioneuroblastoma - surgery</subject><subject>Ganglioneuroblastoma - urine</subject><subject>Humans</subject><subject>Incidental Findings</subject><subject>Male</subject><subject>Paraneoplastic Syndromes - diagnosis</subject><subject>Paraneoplastic Syndromes - etiology</subject><subject>Paraneoplastic Syndromes - physiopathology</subject><subject>Reflex, Abnormal - physiology</subject><subject>Remission Induction</subject><subject>Tomography, X-Ray Computed</subject><issn>1077-4114</issn><issn>1536-3678</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwCyhigdgk2PGbHSqPIlViA2vLcew2kBd2IrV_j0srdcdsZhbnzmgOADcIZghKfg9R1vTrDMZCBDLKM8mgoBmjJ2CKKGYpZlycxhlynhKEyARchPAVcY5Jfg4miBJKBJZT8LTY9tbbjakGXdQ2Keqq_U68dbXdJL23xpZVu0qGtU3KSq_aLlQh6VzS2tF3Ra3D0DX6Epw5XQd7degz8Pny_DFfpMv317f54zI1mIghZbmjklPoMMGaGCglFTkpjTSlc4TQnBEIeYGFtMRQw1yBMYMlZ5pyyUuIZ-B2v7f33c9ow6CaKhhb17q13RgUYzIXlIsI3v0LIhENYZyTHfqwR43vQoiPq95XjfZbhaDa6VYQqahbHXWrP92K0Ri-PtwZi8aWx-jBL_4F4rd7uA</recordid><startdate>200410</startdate><enddate>200410</enddate><creator>Ramadan, Mohamed</creator><creator>Whalen, Bonny</creator><creator>De Santes, Kenneth</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200410</creationdate><title>Hyperexcitable blink reflex preceding the diagnosis of neuroblastoma</title><author>Ramadan, Mohamed ; Whalen, Bonny ; De Santes, Kenneth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-62f59750f343a4c0995824dc9cdff445264007b389e4c5c6fb3360d76a5797d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Abdominal Injuries - complications</topic><topic>Adrenal Gland Neoplasms - complications</topic><topic>Adrenal Gland Neoplasms - diagnosis</topic><topic>Adrenal Gland Neoplasms - diagnostic imaging</topic><topic>Adrenal Gland Neoplasms - secretion</topic><topic>Adrenal Gland Neoplasms - surgery</topic><topic>Adrenal Gland Neoplasms - urine</topic><topic>Blinking - physiology</topic><topic>Catecholamines - secretion</topic><topic>Catecholamines - urine</topic><topic>Child, Preschool</topic><topic>Dopamine - physiology</topic><topic>Ganglioneuroblastoma - complications</topic><topic>Ganglioneuroblastoma - diagnosis</topic><topic>Ganglioneuroblastoma - diagnostic imaging</topic><topic>Ganglioneuroblastoma - secretion</topic><topic>Ganglioneuroblastoma - surgery</topic><topic>Ganglioneuroblastoma - urine</topic><topic>Humans</topic><topic>Incidental Findings</topic><topic>Male</topic><topic>Paraneoplastic Syndromes - diagnosis</topic><topic>Paraneoplastic Syndromes - etiology</topic><topic>Paraneoplastic Syndromes - physiopathology</topic><topic>Reflex, Abnormal - physiology</topic><topic>Remission Induction</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramadan, Mohamed</creatorcontrib><creatorcontrib>Whalen, Bonny</creatorcontrib><creatorcontrib>De Santes, Kenneth</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric hematology/oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramadan, Mohamed</au><au>Whalen, Bonny</au><au>De Santes, Kenneth</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperexcitable blink reflex preceding the diagnosis of neuroblastoma</atitle><jtitle>Journal of pediatric hematology/oncology</jtitle><addtitle>J Pediatr Hematol Oncol</addtitle><date>2004-10</date><risdate>2004</risdate><volume>26</volume><issue>10</issue><spage>665</spage><epage>667</epage><pages>665-667</pages><issn>1077-4114</issn><eissn>1536-3678</eissn><abstract>The diagnosis of neuroblastoma is sometimes preceded by development of a paraneoplastic syndrome, most commonly opsoclonus-myoclonus-ataxia (OMA). The authors describe a patient who developed a hyperexcitable blink reflex, without symptoms of OMA, prior to his oncologic diagnosis. The authors believe this may represent a distinct paraneoplastic process caused by increased dopaminergic stimulation of the blink reflex and suggest that children manifesting an unexplained hyperexcitable blink reflex should be screened for occult neuroblastoma.</abstract><cop>United States</cop><pmid>15454839</pmid><doi>10.1097/01.mph.0000140657.96085.65</doi><tpages>3</tpages></addata></record> |
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| ispartof | Journal of pediatric hematology/oncology, 2004-10, Vol.26 (10), p.665-667 |
| issn | 1077-4114 1536-3678 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Abdominal Injuries - complications Adrenal Gland Neoplasms - complications Adrenal Gland Neoplasms - diagnosis Adrenal Gland Neoplasms - diagnostic imaging Adrenal Gland Neoplasms - secretion Adrenal Gland Neoplasms - surgery Adrenal Gland Neoplasms - urine Blinking - physiology Catecholamines - secretion Catecholamines - urine Child, Preschool Dopamine - physiology Ganglioneuroblastoma - complications Ganglioneuroblastoma - diagnosis Ganglioneuroblastoma - diagnostic imaging Ganglioneuroblastoma - secretion Ganglioneuroblastoma - surgery Ganglioneuroblastoma - urine Humans Incidental Findings Male Paraneoplastic Syndromes - diagnosis Paraneoplastic Syndromes - etiology Paraneoplastic Syndromes - physiopathology Reflex, Abnormal - physiology Remission Induction Tomography, X-Ray Computed |
| title | Hyperexcitable blink reflex preceding the diagnosis of neuroblastoma |
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