Active genes dynamically colocalize to shared sites of ongoing transcription

The intranuclear position of many genes has been correlated with their activity state, suggesting that migration to functional subcompartments may influence gene expression. Indeed, nascent RNA production and RNA polymerase II seem to be localized into discrete foci or 'transcription factories&...

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Veröffentlicht in:	Nature genetics 2004-10, Vol.36 (10), p.1065-1071
Hauptverfasser:	Osborne, Cameron S, Chakalova, Lyubomira, Brown, Karen E, Carter, David, Horton, Alice, Debrand, Emmanuel, Goyenechea, Beatriz, Mitchell, Jennifer A, Lopes, Susana, Reik, Wolf, Fraser, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Blood Proteins - genetics Cancer Research Cell Nucleus - metabolism Cells, Cultured Chromosomes Factories Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation Gene Function Genetic regulation Genetic transcription Genetics of eukaryotes. Biological and molecular evolution Globins - genetics Human Genetics In Situ Hybridization, Fluorescence Insulin-Like Growth Factor II - genetics Medical research Membrane Proteins - genetics Mice Models, Genetic Molecular and cellular biology Molecular Chaperones - genetics Molecular genetics Physiological aspects Potassium Channels, Voltage-Gated RNA polymerase RNA Polymerase II - metabolism Transcription, Genetic Transcription. Transcription factor. Splicing. Rna processing Uroporphyrinogen III Synthetase - genetics
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