Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise

Premature termination codons induce rapid transcript degradation in eukaryotic cells through nonsense-mediated mRNA decay (NMD). This pathway can modulate phenotypes arising from nonsense or frameshift mutations, but little is known about the physiologic role of NMD in higher eukaryotes. To address...

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Veröffentlicht in:	Nature genetics 2004-10, Vol.36 (10), p.1073-1078
Hauptverfasser:	Dietz, Harry C, Mendell, Joshua T, Sharifi, Neda A, Meyers, Jennifer L, Martinez-Murillo, Francisco
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Amino acids Amino Acids - metabolism Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Biosynthesis Cancer Research Cells (Biology) Codon, Nonsense - genetics Codons Decay Frameshift Mutation Fundamental and applied biological sciences. Psychology Gene Expression Regulation Gene Function Genetic regulation Genetics of eukaryotes. Biological and molecular evolution HeLa Cells Homeostasis Human Genetics Humans Identification and classification Kinases letter Mammals Messenger RNA Molecular and cellular biology Molecular genetics Molecular Sequence Data Mutation Nucleotides Phenotypes Phosphatase Physiological aspects Proteins Resveratrol Retrovirus Retroviruses RNA RNA Processing, Post-Transcriptional RNA Stability RNA, Messenger - genetics RNA, Messenger - metabolism Suppression, Genetic Surveillance Trans-Activators - genetics Transcription factors Transcription. Transcription factor. Splicing. Rna processing Transfer RNA Transposons Upstream
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