Metal-Ion Selectivity of Chemically Modified Uracil Pairs in DNA Duplexes

DNA duplexes containing 5-modified uracil pairs (5-bromo, 5-fluoro, and 5-cyanouracil) bind selectivity to metal ions. Their selectivity is sensitive to the pH value of the solution (see picture), as the acidities of the modified uracil bases vary according to the electron-withdrawing properties of...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2009-02, Vol.48 (9), p.1648-1651
Hauptverfasser:	Okamoto, Itaru, Iwamoto, Kenji, Watanabe, Yuko, Miyake, Yoko, Ono, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	bioinorganic chemistry DNA DNA - chemistry Hydrogen-Ion Concentration Ions - chemistry mercury Metals - chemistry nucleobases silver Spectrometry, Mass, Electrospray Ionization Transition Temperature Uracil - chemistry
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Beschreibung
Zusammenfassung:	DNA duplexes containing 5-modified uracil pairs (5-bromo, 5-fluoro, and 5-cyanouracil) bind selectivity to metal ions. Their selectivity is sensitive to the pH value of the solution (see picture), as the acidities of the modified uracil bases vary according to the electron-withdrawing properties of the substituents.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200804952