Use of Bifunctional Ureas to Increase the Rate of Proline-Catalyzed α-Aminoxylations

The rate of the proline-catalyzed α-aminoxylation of aldehydes is significantly increased in the presence of a bifunctional urea. Structure−activity relationship data indicate that both an amine and a urea are crucial for rate enhancement. The evidence presented herein suggests that this rate enhanc...

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