Recurrent demyelinating myelitis associated with hepatitis C viral infection
We report a 46-year-old-man who developed recurrent myelitis associated with hepatitis C viral (HCV) infection. Spinal cord biopsy showed acute demyelination without evidence of vasculitis. Antibodies to HCV were present in the CSF; HCV RNA was not detected in the CSF. Neither HCV antigens nor RNA w...
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| Veröffentlicht in: | Journal of the neurological sciences 2004-09, Vol.224 (1), p.101-106 |
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| container_title | Journal of the neurological sciences |
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| creator | Grewal, Amrit K. Lopes, M. Beatriz Berg, Carl L. Bennett, Audrey K. Alves, Venâncio A.F. Trugman, Joel M. |
| description | We report a 46-year-old-man who developed recurrent myelitis associated with hepatitis C viral (HCV) infection. Spinal cord biopsy showed acute demyelination without evidence of vasculitis. Antibodies to HCV were present in the CSF; HCV RNA was not detected in the CSF. Neither HCV antigens nor RNA were detected in the spinal cord biopsy, whereas they were found in the liver biopsy. Evaluation for other infectious or autoimmune causes was unrevealing. These observations suggest that recurrent myelitis in this patient is etiologically related to HCV infection, possibly via an immune-mediated mechanism. This is the first report of pathologically proven myelitis associated with HCV infection and we suggest that HCV be considered in the differential diagnosis of the transverse myelitis syndrome. |
| doi_str_mv | 10.1016/j.jns.2004.06.013 |
| format | Article |
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Beatriz ; Berg, Carl L. ; Bennett, Audrey K. ; Alves, Venâncio A.F. ; Trugman, Joel M.</creator><creatorcontrib>Grewal, Amrit K. ; Lopes, M. Beatriz ; Berg, Carl L. ; Bennett, Audrey K. ; Alves, Venâncio A.F. ; Trugman, Joel M.</creatorcontrib><description>We report a 46-year-old-man who developed recurrent myelitis associated with hepatitis C viral (HCV) infection. Spinal cord biopsy showed acute demyelination without evidence of vasculitis. Antibodies to HCV were present in the CSF; HCV RNA was not detected in the CSF. Neither HCV antigens nor RNA were detected in the spinal cord biopsy, whereas they were found in the liver biopsy. Evaluation for other infectious or autoimmune causes was unrevealing. These observations suggest that recurrent myelitis in this patient is etiologically related to HCV infection, possibly via an immune-mediated mechanism. This is the first report of pathologically proven myelitis associated with HCV infection and we suggest that HCV be considered in the differential diagnosis of the transverse myelitis syndrome.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/j.jns.2004.06.013</identifier><identifier>PMID: 15450779</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Antigens, CD - metabolism ; Antigens, Differentiation, Myelomonocytic - metabolism ; Biological and medical sciences ; Demyelination ; Glial Fibrillary Acidic Protein - metabolism ; Hepacivirus - metabolism ; Hepacivirus - pathogenicity ; Hepatitis C - complications ; Hepatitis C - pathology ; Hepatitis C - virology ; Hepatitis C virus ; Human viral diseases ; Humans ; Immunohistochemistry ; Immunohistochemistry - methods ; In Situ Hybridization - methods ; Infectious diseases ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Middle Aged ; Myelitis ; Myelitis, Transverse - complications ; Myelitis, Transverse - pathology ; Myelitis, Transverse - virology ; Neurology ; Recurrence ; Spinal Cord - pathology ; Spinal Cord - virology ; Staining and Labeling - methods ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral diseases of the nervous system</subject><ispartof>Journal of the neurological sciences, 2004-09, Vol.224 (1), p.101-106</ispartof><rights>2004 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-a6e4eec99017eebee686f54a1fbebd3fbbf830074fb04cc9cdf819383996a2213</citedby><cites>FETCH-LOGICAL-c379t-a6e4eec99017eebee686f54a1fbebd3fbbf830074fb04cc9cdf819383996a2213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jns.2004.06.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16151908$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15450779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grewal, Amrit K.</creatorcontrib><creatorcontrib>Lopes, M. Beatriz</creatorcontrib><creatorcontrib>Berg, Carl L.</creatorcontrib><creatorcontrib>Bennett, Audrey K.</creatorcontrib><creatorcontrib>Alves, Venâncio A.F.</creatorcontrib><creatorcontrib>Trugman, Joel M.</creatorcontrib><title>Recurrent demyelinating myelitis associated with hepatitis C viral infection</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>We report a 46-year-old-man who developed recurrent myelitis associated with hepatitis C viral (HCV) infection. Spinal cord biopsy showed acute demyelination without evidence of vasculitis. Antibodies to HCV were present in the CSF; HCV RNA was not detected in the CSF. Neither HCV antigens nor RNA were detected in the spinal cord biopsy, whereas they were found in the liver biopsy. Evaluation for other infectious or autoimmune causes was unrevealing. These observations suggest that recurrent myelitis in this patient is etiologically related to HCV infection, possibly via an immune-mediated mechanism. This is the first report of pathologically proven myelitis associated with HCV infection and we suggest that HCV be considered in the differential diagnosis of the transverse myelitis syndrome.</description><subject>Antigens, CD - metabolism</subject><subject>Antigens, Differentiation, Myelomonocytic - metabolism</subject><subject>Biological and medical sciences</subject><subject>Demyelination</subject><subject>Glial Fibrillary Acidic Protein - metabolism</subject><subject>Hepacivirus - metabolism</subject><subject>Hepacivirus - pathogenicity</subject><subject>Hepatitis C - complications</subject><subject>Hepatitis C - pathology</subject><subject>Hepatitis C - virology</subject><subject>Hepatitis C virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Immunohistochemistry - methods</subject><subject>In Situ Hybridization - methods</subject><subject>Infectious diseases</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myelitis</subject><subject>Myelitis, Transverse - complications</subject><subject>Myelitis, Transverse - pathology</subject><subject>Myelitis, Transverse - virology</subject><subject>Neurology</subject><subject>Recurrence</subject><subject>Spinal Cord - pathology</subject><subject>Spinal Cord - virology</subject><subject>Staining and Labeling - methods</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral diseases of the nervous system</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMoun78AC_Si95aJ02bJniSxS9YEETBW0jTiWbppmvSVfz3Zt0Fb55mYJ73ZXgIOaVQUKD8cl7MfSxKgKoAXgBlO2RCRSPyWgi2SyYAZZnXFF4PyGGMcwDgQsh9ckDrqoamkRMye0KzCgH9mHW4-MbeeT06_5b97qOLmY5xME6P2GVfbnzP3nGZiPVlmn26oPvMeYtmdIM_JntW9xFPtvOIvNzePE_v89nj3cP0epYb1sgx1xwrRCMl0AaxReSC27rS1LbYdsy2rRUMoKlsC5Ux0nRWUMkEk5LrsqTsiFxsepdh-FhhHNXCRYN9rz0Oq6g4l2VdsiqBdAOaMMQY0KplcAsdvhUFtVao5iopVGuFCrhKClPmbFu-ahfY_SW2zhJwvgV0NLq3QXvj4h_HaU0liMRdbThMKj4dBhWNQ2-wcyH5Ut3g_nnjB34tkGs</recordid><startdate>20040915</startdate><enddate>20040915</enddate><creator>Grewal, Amrit K.</creator><creator>Lopes, M. Beatriz</creator><creator>Berg, Carl L.</creator><creator>Bennett, Audrey K.</creator><creator>Alves, Venâncio A.F.</creator><creator>Trugman, Joel M.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040915</creationdate><title>Recurrent demyelinating myelitis associated with hepatitis C viral infection</title><author>Grewal, Amrit K. ; Lopes, M. Beatriz ; Berg, Carl L. ; Bennett, Audrey K. ; Alves, Venâncio A.F. ; Trugman, Joel M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-a6e4eec99017eebee686f54a1fbebd3fbbf830074fb04cc9cdf819383996a2213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Antigens, CD - metabolism</topic><topic>Antigens, Differentiation, Myelomonocytic - metabolism</topic><topic>Biological and medical sciences</topic><topic>Demyelination</topic><topic>Glial Fibrillary Acidic Protein - metabolism</topic><topic>Hepacivirus - metabolism</topic><topic>Hepacivirus - pathogenicity</topic><topic>Hepatitis C - complications</topic><topic>Hepatitis C - pathology</topic><topic>Hepatitis C - virology</topic><topic>Hepatitis C virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Immunohistochemistry - methods</topic><topic>In Situ Hybridization - methods</topic><topic>Infectious diseases</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myelitis</topic><topic>Myelitis, Transverse - complications</topic><topic>Myelitis, Transverse - pathology</topic><topic>Myelitis, Transverse - virology</topic><topic>Neurology</topic><topic>Recurrence</topic><topic>Spinal Cord - pathology</topic><topic>Spinal Cord - virology</topic><topic>Staining and Labeling - methods</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral diseases of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grewal, Amrit K.</creatorcontrib><creatorcontrib>Lopes, M. Beatriz</creatorcontrib><creatorcontrib>Berg, Carl L.</creatorcontrib><creatorcontrib>Bennett, Audrey K.</creatorcontrib><creatorcontrib>Alves, Venâncio A.F.</creatorcontrib><creatorcontrib>Trugman, Joel M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grewal, Amrit K.</au><au>Lopes, M. Beatriz</au><au>Berg, Carl L.</au><au>Bennett, Audrey K.</au><au>Alves, Venâncio A.F.</au><au>Trugman, Joel M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recurrent demyelinating myelitis associated with hepatitis C viral infection</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2004-09-15</date><risdate>2004</risdate><volume>224</volume><issue>1</issue><spage>101</spage><epage>106</epage><pages>101-106</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>We report a 46-year-old-man who developed recurrent myelitis associated with hepatitis C viral (HCV) infection. Spinal cord biopsy showed acute demyelination without evidence of vasculitis. Antibodies to HCV were present in the CSF; HCV RNA was not detected in the CSF. Neither HCV antigens nor RNA were detected in the spinal cord biopsy, whereas they were found in the liver biopsy. Evaluation for other infectious or autoimmune causes was unrevealing. These observations suggest that recurrent myelitis in this patient is etiologically related to HCV infection, possibly via an immune-mediated mechanism. This is the first report of pathologically proven myelitis associated with HCV infection and we suggest that HCV be considered in the differential diagnosis of the transverse myelitis syndrome.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>15450779</pmid><doi>10.1016/j.jns.2004.06.013</doi><tpages>6</tpages></addata></record> |
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| subjects | Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Biological and medical sciences Demyelination Glial Fibrillary Acidic Protein - metabolism Hepacivirus - metabolism Hepacivirus - pathogenicity Hepatitis C - complications Hepatitis C - pathology Hepatitis C - virology Hepatitis C virus Human viral diseases Humans Immunohistochemistry Immunohistochemistry - methods In Situ Hybridization - methods Infectious diseases Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged Myelitis Myelitis, Transverse - complications Myelitis, Transverse - pathology Myelitis, Transverse - virology Neurology Recurrence Spinal Cord - pathology Spinal Cord - virology Staining and Labeling - methods Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral diseases of the nervous system |
| title | Recurrent demyelinating myelitis associated with hepatitis C viral infection |
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