Inotropic and Lusitropic Effects Induced by the Inhibitory Factor of the Na/Ca Exchanger Are Not Mediated by the β-Adrenergic Activation

Recently, an endogenous inhibitory factor (NCXIF) of the cardiac Na/Ca exchanger (NCX1) has been isolated, purified, and preliminary characterized. Here, we demonstrate that low doses of NCXIF (1010 M) induce strong inotropic effects in the guinea and rat ventricle strips, while having no detectable...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2004-10, Vol.44 (4), p.466-472
Hauptverfasser:	Shpak, Beni, Shpak, Chagit, Hiller, Reuben, Boyman, Liron, Khananshvili, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-1 Receptor Agonists Adrenergic beta-1 Receptor Antagonists Adrenergic beta-Agonists - pharmacology Adrenergic beta-Antagonists - administration & dosage Adrenergic beta-Antagonists - pharmacology Animals Atrial Function - drug effects Dose-Response Relationship, Drug Guinea Pigs In Vitro Techniques Isometric Contraction - drug effects Isoproterenol - pharmacology Myocardial Contraction - drug effects Myocardial Contraction - physiology Propranolol - pharmacology Rats Receptors, Adrenergic, beta-1 - physiology Sarcolemma - drug effects Sarcolemma - physiology Sodium-Calcium Exchanger - antagonists & inhibitors Sodium-Calcium Exchanger - pharmacology Sodium-Calcium Exchanger - physiology Species Specificity Stimulation, Chemical Ventricular Function
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