Catalytic Asymmetric Hydroxymethylation of Silicon Enolates Using an Aqueous Solution of Formaldehyde with a Chiral Scandium Complex

Catalytic asymmetric hydroxymethylation of silicon enolates has been achieved. In this reaction, an aqueous solution of formaldehyde can be used to realize an easy and safe procedure, and high enantioselectivities have been obtained. This is the first example of catalytic asymmetric reactions in aqu...

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Veröffentlicht in:Journal of the American Chemical Society 2004-10, Vol.126 (39), p.12236-12237
Hauptverfasser: Ishikawa, Shunpei, Hamada, Tomoaki, Manabe, Kei, Kobayashi, Shū
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container_issue 39
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container_title Journal of the American Chemical Society
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creator Ishikawa, Shunpei
Hamada, Tomoaki
Manabe, Kei
Kobayashi, Shū
description Catalytic asymmetric hydroxymethylation of silicon enolates has been achieved. In this reaction, an aqueous solution of formaldehyde can be used to realize an easy and safe procedure, and high enantioselectivities have been obtained. This is the first example of catalytic asymmetric reactions in aqueous media with a chiral scandium complex.
doi_str_mv 10.1021/ja047896i
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Chemistry
Exact sciences and technology
Organic chemistry
Reactivity and mechanisms
title Catalytic Asymmetric Hydroxymethylation of Silicon Enolates Using an Aqueous Solution of Formaldehyde with a Chiral Scandium Complex
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