Riboflavin concentration within ABCG2-rich extracellular vesicles is a novel marker for multidrug resistance in malignant cells

We have previously shown that overexpression of the multidrug resistance (MDR) efflux transporter ABCG2 in the membrane of novel extracellular vesicles that are confined to breast cancer cell–cell attachment zones confers mitoxantrone resistance and mediates a marked intravesicular concentration of...

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Veröffentlicht in:	Biochemical and biophysical research communications 2009-02, Vol.380 (1), p.5-10
Hauptverfasser:	Ifergan, Ilan, Goler-Baron, Vicky, Assaraf, Yehuda G.
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporters Anticancer drugs ATP Binding Cassette Transporter, Sub-Family G, Member 2 ATP-Binding Cassette Transporters - biosynthesis Breast Neoplasms - metabolism Cancer Carcinoma, Non-Small-Cell Lung - metabolism Cell Line, Tumor Cell Membrane - metabolism Drug Resistance, Multiple Drug Resistance, Neoplasm Extracellular vesicles Female Humans Lung Neoplasms - metabolism Multidrug resistance Neoplasm Proteins - biosynthesis Overexpression Riboflavin Riboflavin - metabolism
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