MRI evaluation of treatment of embolic stroke in rat with intra-arterial and intravenous rt-PA
Using magnetic resonance imaging (MRI), we investigated treatment of a rat model of embolic stroke with rt-PA via intra-arterial (IA) and intravenous (IV) routes of administration. Rats were treated with rt-PA by either IA ( n=13) or IV ( n=13) routes at 3 h after stroke induction. Diffusion, perfus...
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| Veröffentlicht in: | Journal of the neurological sciences 2004-09, Vol.224 (1), p.57-67 |
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| creator | Jiang, Quan Zhang, Zheng Gang Zhang, Li Ding, Guang Liang Li, Lian Ewing, James R. Lu, Mei Whitton, Polly Hu, Jiani Li, Qing Jiang Zhang, Rui Lan Chopp, Michael |
| description | Using magnetic resonance imaging (MRI), we investigated treatment of a rat model of embolic stroke with rt-PA via intra-arterial (IA) and intravenous (IV) routes of administration. Rats were treated with rt-PA by either IA (
n=13) or IV (
n=13) routes at 3 h after stroke induction. Diffusion, perfusion, T
2, and magnetization transfer MRI were performed prior to and at 1–3 and at 24 h after embolization. The IA treated group exhibited smaller lesion volumes than the IV treated group (
p=0.02). The relative areas with low ADC
w and cerebral blood flow (CBF) after IA rt-PA intervention were significantly (
p≤0.03) smaller than those in the IV treated group at 24 h after embolization. Significant differences (
p |
| doi_str_mv | 10.1016/j.jns.2004.06.004 |
| format | Article |
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n=13) or IV (
n=13) routes at 3 h after stroke induction. Diffusion, perfusion, T
2, and magnetization transfer MRI were performed prior to and at 1–3 and at 24 h after embolization. The IA treated group exhibited smaller lesion volumes than the IV treated group (
p=0.02). The relative areas with low ADC
w and cerebral blood flow (CBF) after IA rt-PA intervention were significantly (
p≤0.03) smaller than those in the IV treated group at 24 h after embolization. Significant differences (
p<0.02) between IA and IV treated groups in the relative area with high T
2 and inverse of the apparent forward transfer rate of magnetization (
k
inv) in the ipsilateral hemisphere were also detected at 24 h after embolization. The IA treated group exhibited less intracerebral hemorrhage (27%) than the IV treated (64%) groups. Our data suggest that the beneficial effects of IA rt-PA treatment can be detected by changes in CBF, ADC
w, T
2, and
k
inv.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/j.jns.2004.06.004</identifier><identifier>PMID: 15450772</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Blood. Blood coagulation. Reticuloendothelial system ; Brain Mapping ; Cerebral ischemia ; Cerebrovascular Circulation - drug effects ; Diffusion ; Diffusion Magnetic Resonance Imaging ; Disease Models, Animal ; Hemorrhage ; Infarction, Middle Cerebral Artery - complications ; Infarction, Middle Cerebral Artery - drug therapy ; Injections, Intra-Arterial - methods ; Injections, Intravenous - methods ; Intra-arterial ; Intravenous ; Magnetic resonance imaging ; Male ; Medical sciences ; Microscopy, Confocal ; Neurology ; Outcome Assessment (Health Care) ; Perfusion ; Pharmacology. Drug treatments ; Plasminogen Activators - therapeutic use ; Rats ; Rats, Wistar ; Spin–spin relaxation time ; Staining and Labeling ; Stroke - drug therapy ; Stroke - etiology ; Thrombolysis ; Time Factors ; Tissue Plasminogen Activator - therapeutic use ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Journal of the neurological sciences, 2004-09, Vol.224 (1), p.57-67</ispartof><rights>2004 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-ae4bdd850c604e34622a90bf0514efb828c80e27ff162232d8a136a58a25aed3</citedby><cites>FETCH-LOGICAL-c379t-ae4bdd850c604e34622a90bf0514efb828c80e27ff162232d8a136a58a25aed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jns.2004.06.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16151901$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15450772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Quan</creatorcontrib><creatorcontrib>Zhang, Zheng Gang</creatorcontrib><creatorcontrib>Zhang, Li</creatorcontrib><creatorcontrib>Ding, Guang Liang</creatorcontrib><creatorcontrib>Li, Lian</creatorcontrib><creatorcontrib>Ewing, James R.</creatorcontrib><creatorcontrib>Lu, Mei</creatorcontrib><creatorcontrib>Whitton, Polly</creatorcontrib><creatorcontrib>Hu, Jiani</creatorcontrib><creatorcontrib>Li, Qing Jiang</creatorcontrib><creatorcontrib>Zhang, Rui Lan</creatorcontrib><creatorcontrib>Chopp, Michael</creatorcontrib><title>MRI evaluation of treatment of embolic stroke in rat with intra-arterial and intravenous rt-PA</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>Using magnetic resonance imaging (MRI), we investigated treatment of a rat model of embolic stroke with rt-PA via intra-arterial (IA) and intravenous (IV) routes of administration. Rats were treated with rt-PA by either IA (
n=13) or IV (
n=13) routes at 3 h after stroke induction. Diffusion, perfusion, T
2, and magnetization transfer MRI were performed prior to and at 1–3 and at 24 h after embolization. The IA treated group exhibited smaller lesion volumes than the IV treated group (
p=0.02). The relative areas with low ADC
w and cerebral blood flow (CBF) after IA rt-PA intervention were significantly (
p≤0.03) smaller than those in the IV treated group at 24 h after embolization. Significant differences (
p<0.02) between IA and IV treated groups in the relative area with high T
2 and inverse of the apparent forward transfer rate of magnetization (
k
inv) in the ipsilateral hemisphere were also detected at 24 h after embolization. The IA treated group exhibited less intracerebral hemorrhage (27%) than the IV treated (64%) groups. Our data suggest that the beneficial effects of IA rt-PA treatment can be detected by changes in CBF, ADC
w, T
2, and
k
inv.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Brain Mapping</subject><subject>Cerebral ischemia</subject><subject>Cerebrovascular Circulation - drug effects</subject><subject>Diffusion</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Disease Models, Animal</subject><subject>Hemorrhage</subject><subject>Infarction, Middle Cerebral Artery - complications</subject><subject>Infarction, Middle Cerebral Artery - drug therapy</subject><subject>Injections, Intra-Arterial - methods</subject><subject>Injections, Intravenous - methods</subject><subject>Intra-arterial</subject><subject>Intravenous</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Confocal</subject><subject>Neurology</subject><subject>Outcome Assessment (Health Care)</subject><subject>Perfusion</subject><subject>Pharmacology. Drug treatments</subject><subject>Plasminogen Activators - therapeutic use</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Spin–spin relaxation time</subject><subject>Staining and Labeling</subject><subject>Stroke - drug therapy</subject><subject>Stroke - etiology</subject><subject>Thrombolysis</subject><subject>Time Factors</subject><subject>Tissue Plasminogen Activator - therapeutic use</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtv1DAURi0EokPhB7BB3sAu4dqJHUesqopCpSIq1AUrrBvnRnhInGJ7puLf16MZqTtWnx_nPnQYeyugFiD0x229DamWAG0Nui7xjG2E6UyljGmesw2AlJUS8POMvUppCwDamP4lOxOqVdB1csN-fftxzWmP8w6zXwNfJ54jYV4o5MOFlmGdveMpx_UPcR94xMwffP5dzjlihTFT9DhzDOPxaU9h3SUec3V78Zq9mHBO9OaU5-zu6vPd5dfq5vuX68uLm8o1XZ8rpHYYR6PAaWipabWU2MMwgRItTYORxhkg2U2TKF-NHA2KRqMyKBXS2JyzD8e293H9u6OU7eKTo3nGQGUXq3UvpdGigOIIurimFGmy99EvGP9ZAfbg1G5tcWoPTi1oW6LUvDs13w0LjU8VJ4kFeH8CMDmcp4jB-fTEaaFED4fhn44cFRN7T9Em5yk4Gn0kl-24-v-s8QjcHJSF</recordid><startdate>20040915</startdate><enddate>20040915</enddate><creator>Jiang, Quan</creator><creator>Zhang, Zheng Gang</creator><creator>Zhang, Li</creator><creator>Ding, Guang Liang</creator><creator>Li, Lian</creator><creator>Ewing, James R.</creator><creator>Lu, Mei</creator><creator>Whitton, Polly</creator><creator>Hu, Jiani</creator><creator>Li, Qing Jiang</creator><creator>Zhang, Rui Lan</creator><creator>Chopp, Michael</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040915</creationdate><title>MRI evaluation of treatment of embolic stroke in rat with intra-arterial and intravenous rt-PA</title><author>Jiang, Quan ; Zhang, Zheng Gang ; Zhang, Li ; Ding, Guang Liang ; Li, Lian ; Ewing, James R. ; Lu, Mei ; Whitton, Polly ; Hu, Jiani ; Li, Qing Jiang ; Zhang, Rui Lan ; Chopp, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-ae4bdd850c604e34622a90bf0514efb828c80e27ff162232d8a136a58a25aed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Brain Mapping</topic><topic>Cerebral ischemia</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Diffusion</topic><topic>Diffusion Magnetic Resonance Imaging</topic><topic>Disease Models, Animal</topic><topic>Hemorrhage</topic><topic>Infarction, Middle Cerebral Artery - complications</topic><topic>Infarction, Middle Cerebral Artery - drug therapy</topic><topic>Injections, Intra-Arterial - methods</topic><topic>Injections, Intravenous - methods</topic><topic>Intra-arterial</topic><topic>Intravenous</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Confocal</topic><topic>Neurology</topic><topic>Outcome Assessment (Health Care)</topic><topic>Perfusion</topic><topic>Pharmacology. Drug treatments</topic><topic>Plasminogen Activators - therapeutic use</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Spin–spin relaxation time</topic><topic>Staining and Labeling</topic><topic>Stroke - drug therapy</topic><topic>Stroke - etiology</topic><topic>Thrombolysis</topic><topic>Time Factors</topic><topic>Tissue Plasminogen Activator - therapeutic use</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Quan</creatorcontrib><creatorcontrib>Zhang, Zheng Gang</creatorcontrib><creatorcontrib>Zhang, Li</creatorcontrib><creatorcontrib>Ding, Guang Liang</creatorcontrib><creatorcontrib>Li, Lian</creatorcontrib><creatorcontrib>Ewing, James R.</creatorcontrib><creatorcontrib>Lu, Mei</creatorcontrib><creatorcontrib>Whitton, Polly</creatorcontrib><creatorcontrib>Hu, Jiani</creatorcontrib><creatorcontrib>Li, Qing Jiang</creatorcontrib><creatorcontrib>Zhang, Rui Lan</creatorcontrib><creatorcontrib>Chopp, Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Quan</au><au>Zhang, Zheng Gang</au><au>Zhang, Li</au><au>Ding, Guang Liang</au><au>Li, Lian</au><au>Ewing, James R.</au><au>Lu, Mei</au><au>Whitton, Polly</au><au>Hu, Jiani</au><au>Li, Qing Jiang</au><au>Zhang, Rui Lan</au><au>Chopp, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MRI evaluation of treatment of embolic stroke in rat with intra-arterial and intravenous rt-PA</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2004-09-15</date><risdate>2004</risdate><volume>224</volume><issue>1</issue><spage>57</spage><epage>67</epage><pages>57-67</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>Using magnetic resonance imaging (MRI), we investigated treatment of a rat model of embolic stroke with rt-PA via intra-arterial (IA) and intravenous (IV) routes of administration. Rats were treated with rt-PA by either IA (
n=13) or IV (
n=13) routes at 3 h after stroke induction. Diffusion, perfusion, T
2, and magnetization transfer MRI were performed prior to and at 1–3 and at 24 h after embolization. The IA treated group exhibited smaller lesion volumes than the IV treated group (
p=0.02). The relative areas with low ADC
w and cerebral blood flow (CBF) after IA rt-PA intervention were significantly (
p≤0.03) smaller than those in the IV treated group at 24 h after embolization. Significant differences (
p<0.02) between IA and IV treated groups in the relative area with high T
2 and inverse of the apparent forward transfer rate of magnetization (
k
inv) in the ipsilateral hemisphere were also detected at 24 h after embolization. The IA treated group exhibited less intracerebral hemorrhage (27%) than the IV treated (64%) groups. Our data suggest that the beneficial effects of IA rt-PA treatment can be detected by changes in CBF, ADC
w, T
2, and
k
inv.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>15450772</pmid><doi>10.1016/j.jns.2004.06.004</doi><tpages>11</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Brain Mapping Cerebral ischemia Cerebrovascular Circulation - drug effects Diffusion Diffusion Magnetic Resonance Imaging Disease Models, Animal Hemorrhage Infarction, Middle Cerebral Artery - complications Infarction, Middle Cerebral Artery - drug therapy Injections, Intra-Arterial - methods Injections, Intravenous - methods Intra-arterial Intravenous Magnetic resonance imaging Male Medical sciences Microscopy, Confocal Neurology Outcome Assessment (Health Care) Perfusion Pharmacology. Drug treatments Plasminogen Activators - therapeutic use Rats Rats, Wistar Spin–spin relaxation time Staining and Labeling Stroke - drug therapy Stroke - etiology Thrombolysis Time Factors Tissue Plasminogen Activator - therapeutic use Vascular diseases and vascular malformations of the nervous system |
| title | MRI evaluation of treatment of embolic stroke in rat with intra-arterial and intravenous rt-PA |
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