Vitamin c inhibits hypoxia-induced damage and apoptotic signaling pathways in cardiomyocytes and ischemic hearts

Reactive oxygen species play a central role in myocardial ischemic injury and are a target for therapeutic intervention. Vitamin C is an essential antioxidant yet difficult to deliver in pharmacologic concentration to the myocardium. We found that adult rat cardiomyocytes accumulate vitamin C by tra...

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Veröffentlicht in:	Free radical biology & medicine 2004-11, Vol.37 (9), p.1419-1429
Hauptverfasser:	Guaiquil, Victor H., Golde, David W., Beckles, Daniel L., Mascareno, Eduardo J., Siddiqui, M.A.Q.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Apoptosis - physiology Ascorbic acid Ascorbic Acid - pharmacology Cell Hypoxia - drug effects Dehydroascorbic acid Dehydroascorbic Acid - metabolism Disease Models, Animal Free radicals Heart - drug effects Heart - physiology Hypoxia Hypoxia - prevention & control Ischemia Jak/STAT Muscle Cells - cytology Muscle Cells - drug effects Muscle Cells - physiology Myocardial Ischemia - pathology Myocardial Ischemia - prevention & control Myocardium - cytology Rats Rats, Sprague-Dawley Reactive oxygen species Signal Transduction - drug effects Signal Transduction - physiology Signaling
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