A new FTIR-ATR cell for drug diffusion studies
The drug diffusion of most compounds, particularly hydrophilic molecules through the skin is limited by the permeation of the outermost cell layers of the epidermis, the stratum corneum(SC). For this reason it is of interest to characterize drug diffusion processes through this skin layer. A new FTI...
Gespeichert in:
| Veröffentlicht in: | Analyst (London) 2004-01, Vol.129 (10), p.902-905 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 905 |
|---|---|
| container_issue | 10 |
| container_start_page | 902 |
| container_title | Analyst (London) |
| container_volume | 129 |
| creator | HARTMANN, Marcus BUI DUC HANH PODHAISKY, Helmut WENSCH, Jörg BODZENTA, Jerzy WARTEWIG, Siegfried NEUBERT, Reinhard H. H |
| description | The drug diffusion of most compounds, particularly hydrophilic molecules through the skin is limited by the permeation of the outermost cell layers of the epidermis, the stratum corneum(SC). For this reason it is of interest to characterize drug diffusion processes through this skin layer. A new FTIR-ATR cell was developed for non-invasive real time measurements of drug diffusion. The diffusion of water through an artificial polyethyleneglycol-polydimethylsiloxane membrane was studied. Additionally the diffusion of urea in human SC was analyzed. Based on a mathematical model the diffusion coefficients were derived. We could reveal that this cell associates the advantages of the Franz diffusion cell and the FTIR-ATR spectroscopy as a new powerful method for determining drug diffusion through biological membranes. |
| doi_str_mv | 10.1039/b408940p |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66922396</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66922396</sourcerecordid><originalsourceid>FETCH-LOGICAL-c309t-3dc68994920451cca67b6e457f74e714805aa73dc21448a19c7ff72f75df5b3d3</originalsourceid><addsrcrecordid>eNpF0F1LwzAUBuAgiptT8BdIbhRvOk--m8sxnA4GwpjXJU0TqXTtTFbEf7-MVXZ1OPDwnsOL0D2BKQGmX0oOueawu0BjwiTPhKD5JRoDAMuoFHyEbmL8TisBAddoRAQXilEYo-kMt-4XLzbLdTbbrLF1TYN9F3AV-i9c1d73se5aHPd9Vbt4i668aaK7G-YEfS5eN_P3bPXxtpzPVplloPcZq6zMteaaAhfEWiNVKV266RV3ivAchDEqKUo4zw3RVnmvqFei8qJkFZugp1PuLnQ_vYv7YlvH42-mdV0fCyk1pUzLBJ9P0IYuxuB8sQv11oS_gkBx7Kb47ybRhyGzL7euOsOhjAQeB2CiNY0PprV1PDuZTkrO2AExamhb</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>66922396</pqid></control><display><type>article</type><title>A new FTIR-ATR cell for drug diffusion studies</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><source>Royal Society of Chemistry Journals Archive</source><source>Alma/SFX Local Collection</source><creator>HARTMANN, Marcus ; BUI DUC HANH ; PODHAISKY, Helmut ; WENSCH, Jörg ; BODZENTA, Jerzy ; WARTEWIG, Siegfried ; NEUBERT, Reinhard H. H</creator><creatorcontrib>HARTMANN, Marcus ; BUI DUC HANH ; PODHAISKY, Helmut ; WENSCH, Jörg ; BODZENTA, Jerzy ; WARTEWIG, Siegfried ; NEUBERT, Reinhard H. H</creatorcontrib><description>The drug diffusion of most compounds, particularly hydrophilic molecules through the skin is limited by the permeation of the outermost cell layers of the epidermis, the stratum corneum(SC). For this reason it is of interest to characterize drug diffusion processes through this skin layer. A new FTIR-ATR cell was developed for non-invasive real time measurements of drug diffusion. The diffusion of water through an artificial polyethyleneglycol-polydimethylsiloxane membrane was studied. Additionally the diffusion of urea in human SC was analyzed. Based on a mathematical model the diffusion coefficients were derived. We could reveal that this cell associates the advantages of the Franz diffusion cell and the FTIR-ATR spectroscopy as a new powerful method for determining drug diffusion through biological membranes.</description><identifier>ISSN: 0003-2654</identifier><identifier>EISSN: 1364-5528</identifier><identifier>DOI: 10.1039/b408940p</identifier><identifier>PMID: 15457320</identifier><identifier>CODEN: ANALAO</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Analytical chemistry ; Chemistry ; Diffusion ; Exact sciences and technology ; Humans ; Membranes, Artificial ; Pharmacokinetics ; Skin - metabolism ; Skin Absorption ; Spectrometric and optical methods ; Spectroscopy, Fourier Transform Infrared - instrumentation ; Spectroscopy, Fourier Transform Infrared - methods ; Urea - metabolism ; Water - metabolism</subject><ispartof>Analyst (London), 2004-01, Vol.129 (10), p.902-905</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c309t-3dc68994920451cca67b6e457f74e714805aa73dc21448a19c7ff72f75df5b3d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2829,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16223643$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15457320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HARTMANN, Marcus</creatorcontrib><creatorcontrib>BUI DUC HANH</creatorcontrib><creatorcontrib>PODHAISKY, Helmut</creatorcontrib><creatorcontrib>WENSCH, Jörg</creatorcontrib><creatorcontrib>BODZENTA, Jerzy</creatorcontrib><creatorcontrib>WARTEWIG, Siegfried</creatorcontrib><creatorcontrib>NEUBERT, Reinhard H. H</creatorcontrib><title>A new FTIR-ATR cell for drug diffusion studies</title><title>Analyst (London)</title><addtitle>Analyst</addtitle><description>The drug diffusion of most compounds, particularly hydrophilic molecules through the skin is limited by the permeation of the outermost cell layers of the epidermis, the stratum corneum(SC). For this reason it is of interest to characterize drug diffusion processes through this skin layer. A new FTIR-ATR cell was developed for non-invasive real time measurements of drug diffusion. The diffusion of water through an artificial polyethyleneglycol-polydimethylsiloxane membrane was studied. Additionally the diffusion of urea in human SC was analyzed. Based on a mathematical model the diffusion coefficients were derived. We could reveal that this cell associates the advantages of the Franz diffusion cell and the FTIR-ATR spectroscopy as a new powerful method for determining drug diffusion through biological membranes.</description><subject>Analytical chemistry</subject><subject>Chemistry</subject><subject>Diffusion</subject><subject>Exact sciences and technology</subject><subject>Humans</subject><subject>Membranes, Artificial</subject><subject>Pharmacokinetics</subject><subject>Skin - metabolism</subject><subject>Skin Absorption</subject><subject>Spectrometric and optical methods</subject><subject>Spectroscopy, Fourier Transform Infrared - instrumentation</subject><subject>Spectroscopy, Fourier Transform Infrared - methods</subject><subject>Urea - metabolism</subject><subject>Water - metabolism</subject><issn>0003-2654</issn><issn>1364-5528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0F1LwzAUBuAgiptT8BdIbhRvOk--m8sxnA4GwpjXJU0TqXTtTFbEf7-MVXZ1OPDwnsOL0D2BKQGmX0oOueawu0BjwiTPhKD5JRoDAMuoFHyEbmL8TisBAddoRAQXilEYo-kMt-4XLzbLdTbbrLF1TYN9F3AV-i9c1d73se5aHPd9Vbt4i668aaK7G-YEfS5eN_P3bPXxtpzPVplloPcZq6zMteaaAhfEWiNVKV266RV3ivAchDEqKUo4zw3RVnmvqFei8qJkFZugp1PuLnQ_vYv7YlvH42-mdV0fCyk1pUzLBJ9P0IYuxuB8sQv11oS_gkBx7Kb47ybRhyGzL7euOsOhjAQeB2CiNY0PprV1PDuZTkrO2AExamhb</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>HARTMANN, Marcus</creator><creator>BUI DUC HANH</creator><creator>PODHAISKY, Helmut</creator><creator>WENSCH, Jörg</creator><creator>BODZENTA, Jerzy</creator><creator>WARTEWIG, Siegfried</creator><creator>NEUBERT, Reinhard H. H</creator><general>Royal Society of Chemistry</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040101</creationdate><title>A new FTIR-ATR cell for drug diffusion studies</title><author>HARTMANN, Marcus ; BUI DUC HANH ; PODHAISKY, Helmut ; WENSCH, Jörg ; BODZENTA, Jerzy ; WARTEWIG, Siegfried ; NEUBERT, Reinhard H. H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-3dc68994920451cca67b6e457f74e714805aa73dc21448a19c7ff72f75df5b3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Analytical chemistry</topic><topic>Chemistry</topic><topic>Diffusion</topic><topic>Exact sciences and technology</topic><topic>Humans</topic><topic>Membranes, Artificial</topic><topic>Pharmacokinetics</topic><topic>Skin - metabolism</topic><topic>Skin Absorption</topic><topic>Spectrometric and optical methods</topic><topic>Spectroscopy, Fourier Transform Infrared - instrumentation</topic><topic>Spectroscopy, Fourier Transform Infrared - methods</topic><topic>Urea - metabolism</topic><topic>Water - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HARTMANN, Marcus</creatorcontrib><creatorcontrib>BUI DUC HANH</creatorcontrib><creatorcontrib>PODHAISKY, Helmut</creatorcontrib><creatorcontrib>WENSCH, Jörg</creatorcontrib><creatorcontrib>BODZENTA, Jerzy</creatorcontrib><creatorcontrib>WARTEWIG, Siegfried</creatorcontrib><creatorcontrib>NEUBERT, Reinhard H. H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Analyst (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HARTMANN, Marcus</au><au>BUI DUC HANH</au><au>PODHAISKY, Helmut</au><au>WENSCH, Jörg</au><au>BODZENTA, Jerzy</au><au>WARTEWIG, Siegfried</au><au>NEUBERT, Reinhard H. H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new FTIR-ATR cell for drug diffusion studies</atitle><jtitle>Analyst (London)</jtitle><addtitle>Analyst</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>129</volume><issue>10</issue><spage>902</spage><epage>905</epage><pages>902-905</pages><issn>0003-2654</issn><eissn>1364-5528</eissn><coden>ANALAO</coden><abstract>The drug diffusion of most compounds, particularly hydrophilic molecules through the skin is limited by the permeation of the outermost cell layers of the epidermis, the stratum corneum(SC). For this reason it is of interest to characterize drug diffusion processes through this skin layer. A new FTIR-ATR cell was developed for non-invasive real time measurements of drug diffusion. The diffusion of water through an artificial polyethyleneglycol-polydimethylsiloxane membrane was studied. Additionally the diffusion of urea in human SC was analyzed. Based on a mathematical model the diffusion coefficients were derived. We could reveal that this cell associates the advantages of the Franz diffusion cell and the FTIR-ATR spectroscopy as a new powerful method for determining drug diffusion through biological membranes.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><pmid>15457320</pmid><doi>10.1039/b408940p</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-2654 |
| ispartof | Analyst (London), 2004-01, Vol.129 (10), p.902-905 |
| issn | 0003-2654 1364-5528 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66922396 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Royal Society of Chemistry Journals Archive; Alma/SFX Local Collection |
| subjects | Analytical chemistry Chemistry Diffusion Exact sciences and technology Humans Membranes, Artificial Pharmacokinetics Skin - metabolism Skin Absorption Spectrometric and optical methods Spectroscopy, Fourier Transform Infrared - instrumentation Spectroscopy, Fourier Transform Infrared - methods Urea - metabolism Water - metabolism |
| title | A new FTIR-ATR cell for drug diffusion studies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T16%3A06%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20new%20FTIR-ATR%20cell%20for%20drug%20diffusion%20studies&rft.jtitle=Analyst%20(London)&rft.au=HARTMANN,%20Marcus&rft.date=2004-01-01&rft.volume=129&rft.issue=10&rft.spage=902&rft.epage=905&rft.pages=902-905&rft.issn=0003-2654&rft.eissn=1364-5528&rft.coden=ANALAO&rft_id=info:doi/10.1039/b408940p&rft_dat=%3Cproquest_cross%3E66922396%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=66922396&rft_id=info:pmid/15457320&rfr_iscdi=true |