Investigation on the role of the tetrazole in the binding of thiotetrazolylacetanilides with HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases

Different acyclic, cyclic and heterocyclic tetrazole replacements were investigated in order to evaluate the conformational and electronic contribution of the linker in the binding of the tetrazolylacetanilides inhibitors in the NNRTI pocket. The role of the tetrazole moiety in the binding of aryl t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-02, Vol.19 (4), p.1199-1205
Hauptverfasser:	Gagnon, Alexandre, Landry, Serge, Coulombe, René, Jakalian, Araz, Guse, Ingrid, Thavonekham, Bounkham, Bonneau, Pierre R., Yoakim, Christiane, Simoneau, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - chemical synthesis Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology Combinatorial Chemistry Techniques Double mutant reverse transcriptase Drug Design Electrostatic potential HIV Reverse Transcriptase - genetics HIV-1 - drug effects HIV-1 - genetics Human immunodeficiency virus 1 Models, Molecular Molecular modeling Molecular Structure Non-nucleoside reverse transcriptase inhibitors (NNRTIs) Structure-Activity Relationship Tetrazoles - chemical synthesis Tetrazoles - chemistry Tetrazoles - pharmacology Thiotetrazoles
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!