A stress-responsive RNA switch regulates VEGFA expression

Ligand binding to structural elements in the non-coding regions of messenger RNA modulates gene expression. Ligands such as free metabolites or other small molecules directly bind and induce conformational changes in regulatory RNA elements known as riboswitches. Other types of RNA switches are acti...

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Veröffentlicht in:	Nature 2009-02, Vol.457 (7231), p.915-919
Hauptverfasser:	Ray, Partho Sarothi, Fox, Paul L, Majumder, Mithu, Yao, Peng, Jia, Jie, Hatzoglou, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Amino Acyl-tRNA Synthetases Binding sites Biological and medical sciences Cells Environmental conditions Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation Gene Silencing Genetic aspects Genetic regulation Heterogeneous-Nuclear Ribonucleoprotein L - metabolism Humanities and Social Sciences Humans Hypoxia Hypoxia - metabolism Interferon gamma Interferon-gamma - metabolism letter Metabolites Molecular and cellular biology Molecular genetics multidisciplinary Myeloid Cells - metabolism Myeloid Cells - physiology Physiological aspects Physiological research Proteins Ribonucleic acid RNA RNA - chemistry RNA - metabolism Science Signal Transduction Stress Stress (Physiology) Stress, Physiological - physiology Translation. Translation factors. Protein processing U937 Cells Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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