Dihydrofolate reductase amplification and sensitization to methotrexate of methotrexate-resistant colon cancer cells

Gene amplification is one of the most frequent manifestations of genomic instability in human tumors and plays an important role in tumor progression and acquisition of drug resistance. To better understand the factors involved in acquired resistance to cytotoxic drugs via gene amplification, we hav...

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Veröffentlicht in:	Molecular cancer therapeutics 2009-02, Vol.8 (2), p.424-432
Hauptverfasser:	Morales, Cristina, García, Maria J, Ribas, Maria, Miró, Rosa, Muñoz, Mar, Caldas, Carlos, Peinado, Miguel A
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Chromosome Breakage - drug effects Chromosomes, Human, Pair 5 - genetics Chromosomes, Human, Pair 8 - genetics Clone Cells Colonic Neoplasms - enzymology Colonic Neoplasms - genetics Colonic Neoplasms - pathology colorectal cancer drug resistance Drug Resistance, Neoplasm - drug effects Drug Screening Assays, Antitumor gene amplification Gene Amplification - drug effects Gene Dosage - drug effects HT29 Cells Humans In Situ Hybridization, Fluorescence methotrexate Methotrexate - pharmacology Molecular Sequence Data Reverse Transcriptase Polymerase Chain Reaction Tetrahydrofolate Dehydrogenase - genetics
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