Variant t(2;11)(p11;q13) associated with the IgK-CCND1 rearrangement is a recurrent translocation in leukemic small-cell B-non-Hodgkin lymphoma

Classical t(11;14)(q13;q32) involving IGH-CCND1 is typically associated with aggressive CD5-positive mantle cell lymphoma (MCL). Recently, we identified the IGK variant of this translocation, t(2;11)(p11;q13), in three patients with a leukemic small-cell B-non-Hodgkin lymphoma. In all cases, rearran...

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Veröffentlicht in:	Leukemia 2004-10, Vol.18 (10), p.1705-1710
Hauptverfasser:	WLODARSKA, I, MEEUS, P, STUL, M, THIENPONT, L, WOUTERS, E, MARCELIS, L, DEMUYNCK, H, RUMMENS, J-L, MADOE, V, HAGEMEIJER, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens Biological and medical sciences Breakpoints CD5 antigen Cell cycle Chromosome aberrations Chromosomes, Human, Pair 11 - genetics Chromosomes, Human, Pair 2 - genetics Cloning Cyclin D1 Cyclin D1 - genetics Diagnosis Disease Progression DNA, Neoplasm - analysis Fatalities Female Fluorescence Fluorescence in situ hybridization Gene Rearrangement, B-Lymphocyte, Heavy Chain - genetics Genes Genetic Variation Heavy chains Hematologic and hematopoietic diseases Humans Immunoglobulin Heavy Chains - genetics Immunoglobulin Variable Region - genetics Immunoglobulins Immunoglobulins - genetics In Situ Hybridization, Fluorescence Karyotyping Leukemia Leukemia - genetics Leukemia - immunology Leukemia - pathology Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - immunology Leukemia, Lymphocytic, Chronic, B-Cell - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma Lymphoma, Mantle-Cell - genetics Lymphoma, Mantle-Cell - immunology Lymphoma, Mantle-Cell - pathology Lymphoma, Non-Hodgkin - genetics Lymphoma, Non-Hodgkin - immunology Lymphoma, Non-Hodgkin - pathology Male Mantle cell lymphoma Medical genetics Medical sciences Middle Aged Mutation Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Non-Hodgkin's lymphoma Patients Translocation Translocation, Genetic - genetics
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